Summary of CYP3A7
This gene encodes an enzyme that helps during drug metabolism and the synthesis of cholesterol, steroids and other lipids (R).
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The Function of CYP3A7
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Protein names
Recommended name:
Cytochrome P450 3A7Short name:
CYPIIIA7Alternative name(s):
Cytochrome P450-HFLA- RS10211 (CYP3A7) ??
- RS2257401 (CYP3A7) ??
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Top Gene-Substance Interactions
CYP3A7 Interacts with These Diseases
| Disease | Score |
Substances That Increase CYP3A7
| Substances | Interaction | Organism | Category |
Substances That Decrease CYP3A7
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Induction:
P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.
Molecular Function:
- Aromatase Activity
- Estrogen 16-Alpha-Hydroxylase Activity
- Heme Binding
- Iron Ion Binding
- Monooxygenase Activity
- Oxygen Binding
- Steroid Hydroxylase Activity
Biological Processes:
Drug Bank:
- Aminophenazone
- Alfentanil
- Alprazolam
- Amiodarone
- Amlodipine
- Aripiprazole
- Astemizole
- Atorvastatin
- Buprenorphine
- Buspirone
- Caffeine
- Chloramphenicol
- Chlorphenamine
- Cobimetinib
- Daclatasvir
- Fluticasone Propionate
- Imatinib
- Levomethadyl Acetate
- Norethisterone
- Rifampicin
- Salmeterol
- Ciprofloxacin
- Cisapride
- Clarithromycin
- Clotrimazole
- Cocaine
- Codeine
- Cyclophosphamide
- Dapsone
- Delavirdine
- Dexamethasone
- Dextromethorphan
- Dextropropoxyphene
- Diazepam
- Docetaxel
- Dolutegravir
- Domperidone
- Eplerenone
- Erythromycin
- Estradiol
- Ethylmorphine
- Felodipine
- Fentanyl
- Finasteride
- Fluconazole
- Gestodene
- Haloperidol
- Hydrocortisone
- Ifosfamide
- Iloperidone
- Indinavir
- Irinotecan
- Itraconazole
- Ketoconazole
- Lercanidipine
- Lidocaine
- Methadone
- Midazolam
- Mifepristone
- Nateglinide
- Nelfinavir
- Nifedipine
- Nisoldipine
- Nitrendipine
- Norfloxacin
- Oxazepam
- Oxycodone
- Paclitaxel
- Phenelzine
- Phenytoin
- Pimozide
- Praziquantel
- Progesterone
- Propranolol
- Quetiapine
- Quinine
- Rifapentine
- Risperidone
- Ritonavir
- Saquinavir
- Simvastatin
- Sirolimus
- Sorafenib
- Sunitinib
- Tamoxifen
- Telithromycin
- Temsirolimus
- Testosterone
- Trazodone
- Tretinoin
- Verapamil
- Vincristine
- Voriconazole
- Zalcitabine
- Ziprasidone
- Zolpidem
- Aprepitant
- Carbamazepine
- Cilostazol
- Cimetidine
- Cyclosporine
- Diltiazem
- Ethosuximide
- Fluvoxamine
- Imipramine
- Lovastatin
- Nefazodone
- Ondansetron
- Phenobarbital
- Quinidine
- Sildenafil
- Tacrolimus
- Triazolam
- Zaleplon