Summary of CYP3A5
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The enzymes catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids, other lipids, and steroid hormones (R).
The Function of CYP3A5
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Protein names
Recommended name:
Cytochrome P450 3A5Short name:
CYPIIIA5Alternative name(s):
Cytochrome P450 HLp2Cytochrome P450-PCN3
- RS10264272 (CYP3A5) ??
- RS28365083 (CYP3A5) ??
- RS4646450 (CYP3A5) ??
- RS56411402 (CYP3A5) ??
- RS776746 (CYP3A5) ??
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Top Gene-Substance Interactions
CYP3A5 Interacts with These Diseases
Disease | Score |
Substances That Increase CYP3A5
Substances | Interaction | Organism | Category |
Substances That Decrease CYP3A5
Substances | Interaction | Organism | Category |
Advanced Summary
From NCBI Gene: Essential hypertension
From NCBI Gene: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The encoded protein metabolizes drugs as well as the steroid hormones testosterone and progesterone. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Two pseudogenes of this gene have been identified within this cluster on chromosome 7. Expression of this gene is widely variable among populations, and a single nucleotide polymorphism that affects transcript splicing has been associated with susceptibility to hypertensions. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014] From UniProt: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Conditions with Increased Gene Activity
Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Induction:
P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.
Molecular Function:
- Aromatase Activity
- Estrogen 16-Alpha-Hydroxylase Activity
- Heme Binding
- Iron Ion Binding
- Monooxygenase Activity
- Oxidoreductase Activity
- Oxygen Binding
Biological Processes:
- Alkaloid Catabolic Process
- Drug Catabolic Process
- Lipid Hydroxylation
- Oxidative Demethylation
- Steroid Metabolic Process
- Xenobiotic Metabolic Process
Drug Bank:
- Levomethadyl Acetate
- Boceprevir
- Brentuximab Vedotin
- Chlorphenamine
- Cobimetinib
- Daclatasvir
- Enzalutamide
- Erlotinib
- Fluticasone Propionate
- Hydroxyprogesterone Caproate
- Ibrutinib
- Imatinib
- Alfentanil
- Alprazolam
- Ambrisentan
- Amiodarone
- Amitriptyline
- Amlodipine
- Apixaban
- Aprepitant
- Argatroban
- Aripiprazole
- Armodafinil
- Astemizole
- Atorvastatin
- Axitinib
- Azelastine
- Beclomethasone
- Buspirone
- Cabazitaxel
- Caffeine
- Carbamazepine
- Chloramphenicol
- Chloroquine
- Cimetidine
- Ciprofloxacin
- Cisapride
- Clarithromycin
- Clonidine
- Clopidogrel
- Codeine
- Crizotinib
- Cyclophosphamide
- Cyclosporine
- Dapsone
- Dasatinib
- Delavirdine
- Dexamethasone
- Dextromethorphan
- Diazepam
- Diltiazem
- Docetaxel
- Dolutegravir
- Domperidone
- Dutasteride
- Eplerenone
- Estradiol
- Estrone
- Ethosuximide
- Etoposide
- Felodipine
- Fentanyl
- Fluconazole
- Fluoxetine
- Flutamide
- Fluvastatin
- Gefitinib
- Gestodene
- Granisetron
- Halofantrine
- Hydrocortisone
- Ifosfamide
- Iloperidone
- Indinavir
- Irinotecan
- Ketoconazole
- Lapatinib
- Norethisterone
- Paliperidone
- Rifampicin
- Rosuvastatin
- Salmeterol
- Vardenafil
- Losartan
- Lovastatin
- Midazolam
- Mifepristone
- Modafinil
- Mycophenolate Mofetil
- Nateglinide
- Nefazodone
- Nevirapine
- Nicardipine
- Nifedipine
- Nimodipine
- Nitrendipine
- Norfloxacin
- Nortriptyline
- Ondansetron
- Oxazepam
- Oxybutynin
- Oxycodone
- Paclitaxel
- Pentamidine
- Perampanel
- Phenobarbital
- Phenytoin
- Pimozide
- Ponatinib
- Praziquantel
- Progesterone
- Propranolol
- Quetiapine
- Quinacrine
- Quinine
- Reserpine
- Rifapentine
- Risperidone
- Ritonavir
- Romidepsin
- Saquinavir
- Saxagliptin
- Sildenafil
- Sirolimus
- Sorafenib
- Sulfasalazine
- Sunitinib
- Tacrolimus
- Telithromycin
- Temsirolimus
- Teniposide
- Testosterone
- Thalidomide
- Trazodone
- Triazolam
- Troleandomycin
- Udenafil
- Valproic Acid
- Verapamil
- Voriconazole
- Vortioxetine
- Zalcitabine
- Zaleplon
- Ziprasidone
- Zolpidem
- Lercanidipine
- Ado-Trastuzumab Emtansine
- Amprenavir
- Artemether
- Buprenorphine
- Cilostazol
- Cocaine
- Daunorubicin
- Disulfiram
- Erythromycin
- Finasteride
- Fluvoxamine
- Haloperidol
- Itraconazole
- Lidocaine
- Methadone
- Nelfinavir
- Nisoldipine
- Oxcarbazepine
- Phenelzine
- Pravastatin
- Ranitidine
- Rivaroxaban
- Simvastatin
- Tamoxifen
- Tretinoin
- Vincristine