CYP3A5 | SelfDecode | Genome Analysis

Summary of CYP3A5

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The enzymes catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids, other lipids, and steroid hormones (R).

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The Function of CYP3A5

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Protein names

Recommended name:

Cytochrome P450 3A5

Short name:

CYPIIIA5

Alternative name(s):

Cytochrome P450 HLp2
Cytochrome P450-PCN3

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Top Gene-Substance Interactions

CYP3A5 Interacts with These Diseases

Disease	Score

Substances That Increase CYP3A5

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Substances	Interaction	Organism	Category

Substances That Decrease CYP3A5

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Advanced Summary

From NCBI Gene: Essential hypertension

From NCBI Gene: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The encoded protein metabolizes drugs as well as the steroid hormones testosterone and progesterone. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Two pseudogenes of this gene have been identified within this cluster on chromosome 7. Expression of this gene is widely variable among populations, and a single nucleotide polymorphism that affects transcript splicing has been associated with susceptibility to hypertensions. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014] From UniProt: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Conditions with Increased Gene Activity

Experimental Variables:

Condition	Change (log₂fold)	Comparison	Species	Experimental variables	Experiment name

Conditions with Decreased Gene Activity

Experimental Variables:

Condition	Change (log₂fold)	Comparison	Species	Experimental variables	Experiment name

Technical

The following transcription factors affect gene expression:

Gene Pathways:

Induction:

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Molecular Function:

Biological Processes:

Drug Bank:

*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

CYP3A5 (Cytochrome P450 family 3 subfamily A member 5)

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