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  3. CYP3A5

CYP3A5 (Cytochrome P450 family 3 subfamily A member 5)

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Summary of CYP3A5

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The enzymes catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids, other lipids, and steroid hormones (R). 

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The Function of CYP3A5

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Protein names

Recommended name:

Cytochrome P450 3A5

Short name:

CYPIIIA5

Alternative name(s):

Cytochrome P450 HLp2
Cytochrome P450-PCN3

CYP3A5 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS10264272 (CYP3A5) ??
  2. RS28365083 (CYP3A5) ??
  3. RS4646450 (CYP3A5) ??
  4. RS56411402 (CYP3A5) ??
  5. RS776746 (CYP3A5) ??

Top Gene-Substance Interactions

CYP3A5 Interacts with These Diseases

Disease Score

Substances That Increase CYP3A5

Substances Interaction Organism Category

Substances That Decrease CYP3A5

Substances Interaction Organism Category

Advanced Summary

     From NCBI Gene: Essential hypertension

     From NCBI Gene: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The encoded protein metabolizes drugs as well as the steroid hormones testosterone and progesterone. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Two pseudogenes of this gene have been identified within this cluster on chromosome 7. Expression of this gene is widely variable among populations, and a single nucleotide polymorphism that affects transcript splicing has been associated with susceptibility to hypertensions. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014] From UniProt: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • PPAR-gamma1
  • PPAR-gamma2
  • GR
  • GR-alpha
  • GR-beta
  • p53
  • C/EBPbeta
  • C/EBPalpha

Gene Pathways:

  • Metabolic pathways
  • Metabolism
  • Steroid hormone biosynthesis
  • Linoleic acid metabolism
  • Metabolism of xenobiotics by cytochrome P450
  • Retinol metabolism
  • Drug metabolism - cytochrome P450
  • Drug metabolism - other enzymes

Induction:

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Molecular Function:

  • Aromatase Activity
  • Estrogen 16-Alpha-Hydroxylase Activity
  • Heme Binding
  • Iron Ion Binding
  • Monooxygenase Activity
  • Oxidoreductase Activity
  • Oxygen Binding

Biological Processes:

  • Alkaloid Catabolic Process
  • Drug Catabolic Process
  • Lipid Hydroxylation
  • Oxidative Demethylation
  • Steroid Metabolic Process
  • Xenobiotic Metabolic Process

Drug Bank:

  • Levomethadyl Acetate
  • Boceprevir
  • Brentuximab Vedotin
  • Chlorphenamine
  • Cobimetinib
  • Daclatasvir
  • Enzalutamide
  • Erlotinib
  • Fluticasone Propionate
  • Hydroxyprogesterone Caproate
  • Ibrutinib
  • Imatinib
  • Alfentanil
  • Alprazolam
  • Ambrisentan
  • Amiodarone
  • Amitriptyline
  • Amlodipine
  • Apixaban
  • Aprepitant
  • Argatroban
  • Aripiprazole
  • Armodafinil
  • Astemizole
  • Atorvastatin
  • Axitinib
  • Azelastine
  • Beclomethasone
  • Buspirone
  • Cabazitaxel
  • Caffeine
  • Carbamazepine
  • Chloramphenicol
  • Chloroquine
  • Cimetidine
  • Ciprofloxacin
  • Cisapride
  • Clarithromycin
  • Clonidine
  • Clopidogrel
  • Codeine
  • Crizotinib
  • Cyclophosphamide
  • Cyclosporine
  • Dapsone
  • Dasatinib
  • Delavirdine
  • Dexamethasone
  • Dextromethorphan
  • Diazepam
  • Diltiazem
  • Docetaxel
  • Dolutegravir
  • Domperidone
  • Dutasteride
  • Eplerenone
  • Estradiol
  • Estrone
  • Ethosuximide
  • Etoposide
  • Felodipine
  • Fentanyl
  • Fluconazole
  • Fluoxetine
  • Flutamide
  • Fluvastatin
  • Gefitinib
  • Gestodene
  • Granisetron
  • Halofantrine
  • Hydrocortisone
  • Ifosfamide
  • Iloperidone
  • Indinavir
  • Irinotecan
  • Ketoconazole
  • Lapatinib
  • Norethisterone
  • Paliperidone
  • Rifampicin
  • Rosuvastatin
  • Salmeterol
  • Vardenafil
  • Losartan
  • Lovastatin
  • Midazolam
  • Mifepristone
  • Modafinil
  • Mycophenolate Mofetil
  • Nateglinide
  • Nefazodone
  • Nevirapine
  • Nicardipine
  • Nifedipine
  • Nimodipine
  • Nitrendipine
  • Norfloxacin
  • Nortriptyline
  • Ondansetron
  • Oxazepam
  • Oxybutynin
  • Oxycodone
  • Paclitaxel
  • Pentamidine
  • Perampanel
  • Phenobarbital
  • Phenytoin
  • Pimozide
  • Ponatinib
  • Praziquantel
  • Progesterone
  • Propranolol
  • Quetiapine
  • Quinacrine
  • Quinine
  • Reserpine
  • Rifapentine
  • Risperidone
  • Ritonavir
  • Romidepsin
  • Saquinavir
  • Saxagliptin
  • Sildenafil
  • Sirolimus
  • Sorafenib
  • Sulfasalazine
  • Sunitinib
  • Tacrolimus
  • Telithromycin
  • Temsirolimus
  • Teniposide
  • Testosterone
  • Thalidomide
  • Trazodone
  • Triazolam
  • Troleandomycin
  • Udenafil
  • Valproic Acid
  • Verapamil
  • Voriconazole
  • Vortioxetine
  • Zalcitabine
  • Zaleplon
  • Ziprasidone
  • Zolpidem
  • Lercanidipine
  • Ado-Trastuzumab Emtansine
  • Amprenavir
  • Artemether
  • Buprenorphine
  • Cilostazol
  • Cocaine
  • Daunorubicin
  • Disulfiram
  • Erythromycin
  • Finasteride
  • Fluvoxamine
  • Haloperidol
  • Itraconazole
  • Lidocaine
  • Methadone
  • Nelfinavir
  • Nisoldipine
  • Oxcarbazepine
  • Phenelzine
  • Pravastatin
  • Ranitidine
  • Rivaroxaban
  • Simvastatin
  • Tamoxifen
  • Tretinoin
  • Vincristine
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| flavoprotein-linked monooxygenase| microsomal monooxygenase| aryl hydrocarbon hydroxylase| xenobiotic monooxygenase| cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4| CP35| Cyp3A21| CYP3A28| CYP3A4| CYP3A66| CYPIIIA28| CYPIIIA5| cytochrome P450 3A28| cytochrome P450 3A5| cytochrome P450 CYP3A66| cytochrome P450, family 3, subfamily A, polypeptide 5| cytochrome P450 HLp2| cytochrome P450-PCN3| cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 5| P450PCN3| PCN3| cyp3a5

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