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  3. CYP3A43

CYP3A43 (Cytochrome P450 family 3 subfamily A member 43)

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Summary of CYP3A43

This gene encodes a protein that catalyzes many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. It may also play a role in cancer progresssion (R).

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The Function of CYP3A43

Exhibits low testosterone 6-beta-hydroxylase activity.

Protein names

Recommended name:

Cytochrome P450 3A43

CYP3A43 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS17342647 (CYP3A43) ??
  2. RS62471956 (CYP3A43) ??
  3. RS680055 (CYP3A43) ??

Top Gene-Substance Interactions

Substances That Increase CYP3A43

Substances Interaction Organism Category

Substances That Decrease CYP3A43

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • PPAR-gamma1
  • PPAR-gamma2
  • C/EBPalpha
  • GATA-1
  • CAR
  • PXR

Tissue specificity:

Highest expression level in prostate. Also expressed in liver, kidney, pancreas, fetal liver and fetal skeletal muscle.

Gene Pathways:

  • Metabolic pathways
  • Metabolism
  • Steroid hormone biosynthesis
  • Linoleic acid metabolism
  • Metabolism of xenobiotics by cytochrome P450
  • Retinol metabolism
  • Drug metabolism - cytochrome P450
  • Drug metabolism - other enzymes

Induction:

By rifampicin.

Molecular Function:

  • Aromatase Activity
  • Heme Binding
  • Iron Ion Binding
  • Monooxygenase Activity

Drug Bank:

  • Cobimetinib
  • Daclatasvir
  • Rifampicin
  • Dolutegravir
  • Ethosuximide
  • Netupitant
  • Oxazepam
  • Phenelzine
  • Praziquantel
  • Testosterone
  • Troleandomycin
  • Zalcitabine
  • Dexamethasone
  • Rifapentine
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

cytochrome P450 3A43| cytochrome P450, family 3, subfamily A, polypeptide 43| cytochrome P450 subfamily IIIA polypeptide 43| cytochrome P450, subfamily IIIA, polypeptide 43| cyp3a43

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