Summary of CYP3A43
This gene encodes a protein that catalyzes many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. It may also play a role in cancer progresssion (R).
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0 users want it decreased
The Function of CYP3A43
Exhibits low testosterone 6-beta-hydroxylase activity.
Protein names
Recommended name:
Cytochrome P450 3A43- RS17342647 (CYP3A43) ??
- RS62471956 (CYP3A43) ??
- RS680055 (CYP3A43) ??
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Top Gene-Substance Interactions
Substances That Increase CYP3A43
| Substances | Interaction | Organism | Category |
Substances That Decrease CYP3A43
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Highest expression level in prostate. Also expressed in liver, kidney, pancreas, fetal liver and fetal skeletal muscle.
Gene Pathways:
Induction:
By rifampicin.
Molecular Function:
Drug Bank:
- Cobimetinib
- Daclatasvir
- Rifampicin
- Dolutegravir
- Ethosuximide
- Netupitant
- Oxazepam
- Phenelzine
- Praziquantel
- Testosterone
- Troleandomycin
- Zalcitabine
- Dexamethasone
- Rifapentine