Summary of CYP2E1
CYP2E1 encodes for an enzyme (Cytochrome P450 2E1) and catalyzes reactions involved in drug metabolism and synthesis of cholesterol, steroids, and other lipids (R).
The protein is induced by ethanol, the diabetic state, and starvation; because it metabolizes many types of substrates, the gene is related to gluconeogenesis, hepatic cirrhosis, diabetes, and cancer (R).
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The Function of CYP2E1
Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms.
Protein names
Recommended name:
Cytochrome P450 2E1Short name:
CYPIIE1Alternative name(s):
4-nitrophenol 2-hydroxylaseCytochrome P450-J
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- RS2070672 (CYP2E1) ??
- RS2070673 (CYP2E1) ??
- RS2070676 (CYP2E1) ??
- RS2249694 (CYP2E1) ??
- RS2249695 (CYP2E1) ??
- RS2515641 (CYP2E1) ??
- RS3813865 (CYP2E1) ??
- RS3813867 (CYP2E1) ??
- RS4646976 (CYP2E1) ??
- RS55897648 (CYP2E1) ??
- RS6413419 (CYP2E1) ??
- RS6413420 (CYP2E1) ??
- RS8192772 (CYP2E1) ??
- RS915908 (CYP2E1) ??
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Top Gene-Substance Interactions
CYP2E1 Interacts with These Diseases
| Disease | Score |
Substances That Increase CYP2E1
| Substances | Interaction | Organism | Category |
Substances That Decrease CYP2E1
| Substances | Interaction | Organism | Category |
Advanced Summary
CYP2E1 encodes for an enzyme (Cytochrome P450 2E1) and catalyzes reactions involved in drug metabolism and synthesis of cholesterol, steroids, and other lipids (R).
The protein is induced by ethanol, the diabetic state, and starvation; because it metabolizes many types of substrates, the gene is related to gluconeogenesis, hepatic cirrhosis, diabetes, and cancer (R).
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Induction:
By ethanol and isoniazid.
Molecular Function:
- Monooxygenase Activity
- Iron Ion Binding
- Arachidonic Acid Epoxygenase Activity
- Steroid Hydroxylase Activity
- 3-(3-Hydroxyphenyl)Propionate Hydroxylase Activity
- Oxidoreductase Activity
- Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Nad(P)H As One Donor, And Incorporation Of One Atom Of Oxygen
- Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen
- 4-Chlorobenzaldehyde Oxidase Activity
- 3,5-Xylenol Methylhydroxylase Activity
- Phenylacetate Hydroxylase Activity
- 4-Nitrophenol 4-Monooxygenase Activity
- Dimethyl Sulfide Monooxygenase Activity
- Phenanthrene 9,10-Monooxygenase Activity
- 1-Hydroxy-2-Naphthoate Hydroxylase Activity
- Toluene 4-Monooxygenase Activity
- Xylene Monooxygenase Activity
- Dibenzothiophene Monooxygenase Activity
- 6-Hydroxy-3-Methyl-2-Oxo-1,2-Dihydroquinoline 6-Monooxygenase Activity
- Chlorophenol 4-Monooxygenase Activity
- Carbon Disulfide Oxygenase Activity
- Toluene 2-Monooxygenase Activity
- 1-Hydroxy-2-Oxolimonene 1,2-Monooxygenase Activity
- Phenanthrene 1,2-Monooxygenase Activity
- Tetrahydrofuran Hydroxylase Activity
- Styrene Monooxygenase Activity
- Toluene-4-Sulfonate Monooxygenase Activity
- Toluene-Sulfonate Methyl-Monooxygenase Activity
- 3-Methyl-2-Oxo-1,2-Dihydroquinoline 6-Monooxygenase Activity
- 2-Hydroxy-Phenylacetate Hydroxylase Activity
- 2-Oxo-Delta3-4,5,5-Trimethylcyclopentenylacetyl-Coa 1,2-Monooxygenase Activity
- Phenanthrene 3,4-Monooxygenase Activity
- Toluene 3-Monooxygenase Activity
- 4-Hydroxyphenylacetate,Nadh:Oxygen Oxidoreductase (3-Hydroxylating) Activity
- Limonene Monooxygenase Activity
- Oxygen Binding
- Enzyme Binding
- Heme Binding
- 2-Methylnaphthalene Hydroxylase Activity
- 1-Methylnaphthalene Hydroxylase Activity
- Bisphenol A Hydroxylase A Activity
- Salicylate 5-Hydroxylase Activity
- Isobutylamine N-Hydroxylase Activity
- Branched-Chain Dodecylbenzene Sulfonate Monooxygenase Activity
- 3-Hsa Hydroxylase Activity
- 4-Hydroxypyridine-3-Hydroxylase Activity
- 2-Octaprenyl-3-Methyl-6-Methoxy-1,4-Benzoquinol Hydroxylase Activity
- 6-Hydroxynicotinate 3-Monooxygenase Activity
- Tocotrienol Omega-Hydroxylase Activity
- Thalianol Hydroxylase Activity
- Alpha-Pinene Monooxygenase
Biological Processes:
- Triglyceride Metabolic Process
- Xenobiotic Metabolic Process
- Steroid Metabolic Process
- Response To Ozone
- Response To Organonitrogen Compound
- Monoterpenoid Metabolic Process
- Drug Metabolic Process
- Carbon Tetrachloride Metabolic Process
- Benzene Metabolic Process
- Epoxygenase P450 Pathway
- Halogenated Hydrocarbon Metabolic Process
- Response To Ethanol
- Heterocycle Metabolic Process
- Oxidation-Reduction Process
Drug Bank:
- Clomifene
- Dalfampridine
- Acetaminophen
- Aldesleukin
- Almotriptan
- Alosetron
- Amitriptyline
- Antipyrine
- Azelastine
- Benzyl Alcohol
- Bifonazole
- Bromazepam
- Bupropion
- Caffeine
- Capsaicin
- Carbinoxamine
- Carvedilol
- Chlorzoxazone
- Cimetidine
- Citalopram
- Clevidipine
- Clofibrate
- Clonazepam
- Clozapine
- Colchicine
- Dacarbazine
- Dapsone
- Desipramine
- Dexfenfluramine
- Dexmedetomidine
- Dextromethorphan
- Diazepam
- Diclofenac
- Fingolimod
- Menadione
- Nicotinamide
- Rifampicin
- Disulfiram
- Econazole
- Enfuvirtide
- Estrone
- Ethanol
- Ethanolamine Oleate
- Ethosuximide
- Etoposide
- Felbamate
- Flunitrazepam
- Fluphenazine
- Flurazepam
- Fluvoxamine
- Folic Acid
- Glucosamine
- Halothane
- Hexobarbital
- Iloperidone
- Isoflurane
- Isoniazid
- Isosorbide Dinitrate
- Itraconazole
- Meprobamate
- Methazolamide
- Methotrimeprazine
- Methoxyflurane
- Metyrapone
- Mexiletine
- Miconazole
- Mitoxantrone
- Nicardipine
- Nifedipine
- Nilvadipine
- Nortriptyline
- Ondansetron
- Orphenadrine
- Oxaliplatin
- Paramethadione
- Phenelzine
- Pilocarpine
- Pimozide
- Proguanil
- Propofol
- Quinine
- Ritonavir
- Rufinamide
- S-Adenosylmethionine
- Selegiline
- Sevoflurane
- Streptozocin
- Sulfadiazine
- Sulfanilamide
- Tamoxifen
- Thalidomide
- Theobromine
- Thiopental
- Thioridazine
- Ticlopidine
- Tioconazole
- Trabectedin
- Trimethadione
- Ursodeoxycholic Acid
- Zafirlukast
- Zopiclone
- Nicotine
- Aminophylline
- Brompheniramine
- Chlorpromazine
- Clotrimazole
- Dexamethasone
- Diethylstilbestrol
- Enflurane
- Etoricoxib
- Fomepizole
- Imipramine
- Methimazole
- Midazolam
- Nitrazepam
- Phenobarbital
- Quinidine
- Sildenafil
- Theophylline
- Tranylcypromine