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  3. CYP2E1

CYP2E1 (Cytochrome P450 family 2 subfamily E member 1)

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Summary of CYP2E1

CYP2E1 encodes for an enzyme (Cytochrome P450 2E1) and catalyzes reactions involved in drug metabolism and synthesis of cholesterol, steroids, and other lipids (R). 

The protein is induced by ethanol, the diabetic state, and starvation; because it metabolizes many types of substrates, the gene is related to gluconeogenesis, hepatic cirrhosis, diabetes, and cancer (R). 

0 users want this gene increased, 0 users want it decreased

The Function of CYP2E1

Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms.

Protein names

Recommended name:

Cytochrome P450 2E1

Short name:

CYPIIE1

Alternative name(s):

4-nitrophenol 2-hydroxylase
Cytochrome P450-J

CYP2E1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS1329149 (CYP2E1) ??
  2. RS2031920 (CYP2E1) ??
  3. RS2070672 (CYP2E1) ??
  4. RS2070673 (CYP2E1) ??
  5. RS2070676 (CYP2E1) ??
  6. RS2249694 (CYP2E1) ??
  7. RS2249695 (CYP2E1) ??
  8. RS2515641 (CYP2E1) ??
  9. RS3813865 (CYP2E1) ??
  10. RS3813867 (CYP2E1) ??
  11. RS4646976 (CYP2E1) ??
  12. RS55897648 (CYP2E1) ??
  13. RS6413419 (CYP2E1) ??
  14. RS6413420 (CYP2E1) ??
  15. RS8192772 (CYP2E1) ??
  16. RS915908 (CYP2E1) ??

Top Gene-Substance Interactions

CYP2E1 Interacts with These Diseases

Disease Score

Substances That Increase CYP2E1

Substances Interaction Organism Category

Substances That Decrease CYP2E1

Substances Interaction Organism Category

Advanced Summary

CYP2E1 encodes for an enzyme (Cytochrome P450 2E1) and catalyzes reactions involved in drug metabolism and synthesis of cholesterol, steroids, and other lipids (R). 

The protein is induced by ethanol, the diabetic state, and starvation; because it metabolizes many types of substrates, the gene is related to gluconeogenesis, hepatic cirrhosis, diabetes, and cancer (R). 

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • GR
  • AP-1
  • AhR
  • c-Jun
  • NF-kappaB1
  • STAT1
  • STAT1beta
  • STAT1alpha

Gene Pathways:

  • Metabolic pathways
  • Metabolism
  • Linoleic acid metabolism
  • Metabolism of xenobiotics by cytochrome P450
  • Arachidonic acid metabolism
  • Drug metabolism - cytochrome P450

Induction:

By ethanol and isoniazid.

Molecular Function:

  • 1-Hydroxy-2-Naphthoate Hydroxylase Activity
  • 1-Hydroxy-2-Oxolimonene 1,2-Monooxygenase Activity
  • 1-Methylnaphthalene Hydroxylase Activity
  • 2-Hydroxy-Phenylacetate Hydroxylase Activity
  • 2-Methylnaphthalene Hydroxylase Activity
  • 2-Octaprenyl-3-Methyl-6-Methoxy-1,4-Benzoquinol Hydroxylase Activity
  • 2-Oxo-Delta3-4,5,5-Trimethylcyclopentenylacetyl-Coa 1,2-Monooxygenase Activity
  • 3,5-Xylenol Methylhydroxylase Activity
  • 3-(3-Hydroxyphenyl)Propionate Hydroxylase Activity
  • 3-Hsa Hydroxylase Activity
  • 3-Methyl-2-Oxo-1,2-Dihydroquinoline 6-Monooxygenase Activity
  • 4-Chlorobenzaldehyde Oxidase Activity
  • 4-Hydroxyphenylacetate,Nadh:Oxygen Oxidoreductase (3-Hydroxylating) Activity
  • 4-Hydroxypyridine-3-Hydroxylase Activity
  • 4-Nitrophenol 4-Monooxygenase Activity
  • 6-Hydroxy-3-Methyl-2-Oxo-1,2-Dihydroquinoline 6-Monooxygenase Activity
  • 6-Hydroxynicotinate 3-Monooxygenase Activity
  • Alpha-Pinene Monooxygenase
  • Arachidonic Acid Epoxygenase Activity
  • Bisphenol A Hydroxylase A Activity
  • Branched-Chain Dodecylbenzene Sulfonate Monooxygenase Activity
  • Carbon Disulfide Oxygenase Activity
  • Chlorophenol 4-Monooxygenase Activity
  • Dibenzothiophene Monooxygenase Activity
  • Dimethyl Sulfide Monooxygenase Activity
  • Enzyme Binding
  • Heme Binding
  • Iron Ion Binding
  • Isobutylamine N-Hydroxylase Activity
  • Limonene Monooxygenase Activity
  • Monooxygenase Activity
  • Oxidoreductase Activity
  • Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Nad(P)H As One Donor, And Incorporation Of One Atom Of Oxygen
  • Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen
  • Oxygen Binding
  • Phenanthrene 1,2-Monooxygenase Activity
  • Phenanthrene 3,4-Monooxygenase Activity
  • Phenanthrene 9,10-Monooxygenase Activity
  • Phenylacetate Hydroxylase Activity
  • Salicylate 5-Hydroxylase Activity
  • Steroid Hydroxylase Activity
  • Styrene Monooxygenase Activity
  • Tetrahydrofuran Hydroxylase Activity
  • Thalianol Hydroxylase Activity
  • Tocotrienol Omega-Hydroxylase Activity
  • Toluene 2-Monooxygenase Activity
  • Toluene 3-Monooxygenase Activity
  • Toluene 4-Monooxygenase Activity
  • Toluene-4-Sulfonate Monooxygenase Activity
  • Toluene-Sulfonate Methyl-Monooxygenase Activity
  • Xylene Monooxygenase Activity

Biological Processes:

  • Benzene Metabolic Process
  • Carbon Tetrachloride Metabolic Process
  • Drug Metabolic Process
  • Epoxygenase P450 Pathway
  • Halogenated Hydrocarbon Metabolic Process
  • Heterocycle Metabolic Process
  • Monoterpenoid Metabolic Process
  • Oxidation-Reduction Process
  • Response To Ethanol
  • Response To Organonitrogen Compound
  • Response To Ozone
  • Steroid Metabolic Process
  • Triglyceride Metabolic Process
  • Xenobiotic Metabolic Process

Drug Bank:

  • Clomifene
  • Dalfampridine
  • Acetaminophen
  • Aldesleukin
  • Almotriptan
  • Alosetron
  • Amitriptyline
  • Antipyrine
  • Azelastine
  • Benzyl Alcohol
  • Bifonazole
  • Bromazepam
  • Bupropion
  • Caffeine
  • Capsaicin
  • Carbinoxamine
  • Carvedilol
  • Chlorzoxazone
  • Cimetidine
  • Citalopram
  • Clevidipine
  • Clofibrate
  • Clonazepam
  • Clozapine
  • Colchicine
  • Dacarbazine
  • Dapsone
  • Desipramine
  • Dexfenfluramine
  • Dexmedetomidine
  • Dextromethorphan
  • Diazepam
  • Diclofenac
  • Fingolimod
  • Menadione
  • Nicotinamide
  • Rifampicin
  • Disulfiram
  • Econazole
  • Enfuvirtide
  • Estrone
  • Ethanol
  • Ethanolamine Oleate
  • Ethosuximide
  • Etoposide
  • Felbamate
  • Flunitrazepam
  • Fluphenazine
  • Flurazepam
  • Fluvoxamine
  • Folic Acid
  • Glucosamine
  • Halothane
  • Hexobarbital
  • Iloperidone
  • Isoflurane
  • Isoniazid
  • Isosorbide Dinitrate
  • Itraconazole
  • Meprobamate
  • Methazolamide
  • Methotrimeprazine
  • Methoxyflurane
  • Metyrapone
  • Mexiletine
  • Miconazole
  • Mitoxantrone
  • Nicardipine
  • Nifedipine
  • Nilvadipine
  • Nortriptyline
  • Ondansetron
  • Orphenadrine
  • Oxaliplatin
  • Paramethadione
  • Phenelzine
  • Pilocarpine
  • Pimozide
  • Proguanil
  • Propofol
  • Quinine
  • Ritonavir
  • Rufinamide
  • S-Adenosylmethionine
  • Selegiline
  • Sevoflurane
  • Streptozocin
  • Sulfadiazine
  • Sulfanilamide
  • Tamoxifen
  • Thalidomide
  • Theobromine
  • Thiopental
  • Thioridazine
  • Ticlopidine
  • Tioconazole
  • Trabectedin
  • Trimethadione
  • Ursodeoxycholic Acid
  • Zafirlukast
  • Zopiclone
  • Nicotine
  • Aminophylline
  • Brompheniramine
  • Chlorpromazine
  • Clotrimazole
  • Dexamethasone
  • Diethylstilbestrol
  • Enflurane
  • Etoricoxib
  • Fomepizole
  • Imipramine
  • Methimazole
  • Midazolam
  • Nitrazepam
  • Phenobarbital
  • Quinidine
  • Sildenafil
  • Theophylline
  • Tranylcypromine
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| flavoprotein-linked monooxygenase| microsomal monooxygenase| xenobiotic monooxygenase| 4-nitrophenol 2-hydroxylase| CPE1| Cyp2e| CYPIIE1| cytochrome P-450| cytochrome P450 2E1| cytochrome P450, 2e1, ethanol inducible| cytochrome P450-ALC| cytochrome P450 CYP2E1| cytochrome P450, family 2, subfamily e, polypeptide 1| cytochrome P-450-J| cytochrome P450-J| cytochrome P450RLM6| cytochrome P450 subfamily 2e1 (ethanol-inducible)| cytochrome P450, subfamily 2E, polypeptide 1| cytochrome P450, subfamily IIE (ethanol-inducible), polypeptide 1| P450C2E| P450-J| P450RLM6| cyp2e1

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