Summary of CYP2E1
CYP2E1 encodes for an enzyme (Cytochrome P450 2E1) and catalyzes reactions involved in drug metabolism and synthesis of cholesterol, steroids, and other lipids (R).
The protein is induced by ethanol, the diabetic state, and starvation; because it metabolizes many types of substrates, the gene is related to gluconeogenesis, hepatic cirrhosis, diabetes, and cancer (R).
0 users want this gene increased,
0 users want it decreased
The Function of CYP2E1
Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms.
Protein names
Recommended name:
Cytochrome P450 2E1Short name:
CYPIIE1Alternative name(s):
4-nitrophenol 2-hydroxylaseCytochrome P450-J
- RS1329149 (CYP2E1) ??
- RS2031920 (CYP2E1) ??
- RS2070672 (CYP2E1) ??
- RS2070673 (CYP2E1) ??
- RS2070676 (CYP2E1) ??
- RS2249694 (CYP2E1) ??
- RS2249695 (CYP2E1) ??
- RS2515641 (CYP2E1) ??
- RS3813865 (CYP2E1) ??
- RS3813867 (CYP2E1) ??
- RS4646976 (CYP2E1) ??
- RS55897648 (CYP2E1) ??
- RS6413419 (CYP2E1) ??
- RS6413420 (CYP2E1) ??
- RS8192772 (CYP2E1) ??
- RS915908 (CYP2E1) ??
To see your genotype, you should be logged in and have a file with your genotype uploaded.
Top Gene-Substance Interactions
CYP2E1 Interacts with These Diseases
| Disease | Score |
Substances That Increase CYP2E1
| Substances | Interaction | Organism | Category |
Substances That Decrease CYP2E1
| Substances | Interaction | Organism | Category |
Advanced Summary
CYP2E1 encodes for an enzyme (Cytochrome P450 2E1) and catalyzes reactions involved in drug metabolism and synthesis of cholesterol, steroids, and other lipids (R).
The protein is induced by ethanol, the diabetic state, and starvation; because it metabolizes many types of substrates, the gene is related to gluconeogenesis, hepatic cirrhosis, diabetes, and cancer (R).
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Gene Pathways:
Induction:
By ethanol and isoniazid.
Molecular Function:
- 1-Hydroxy-2-Naphthoate Hydroxylase Activity
- 1-Hydroxy-2-Oxolimonene 1,2-Monooxygenase Activity
- 1-Methylnaphthalene Hydroxylase Activity
- 2-Hydroxy-Phenylacetate Hydroxylase Activity
- 2-Methylnaphthalene Hydroxylase Activity
- 2-Octaprenyl-3-Methyl-6-Methoxy-1,4-Benzoquinol Hydroxylase Activity
- 2-Oxo-Delta3-4,5,5-Trimethylcyclopentenylacetyl-Coa 1,2-Monooxygenase Activity
- 3,5-Xylenol Methylhydroxylase Activity
- 3-(3-Hydroxyphenyl)Propionate Hydroxylase Activity
- 3-Hsa Hydroxylase Activity
- 3-Methyl-2-Oxo-1,2-Dihydroquinoline 6-Monooxygenase Activity
- 4-Chlorobenzaldehyde Oxidase Activity
- 4-Hydroxyphenylacetate,Nadh:Oxygen Oxidoreductase (3-Hydroxylating) Activity
- 4-Hydroxypyridine-3-Hydroxylase Activity
- 4-Nitrophenol 4-Monooxygenase Activity
- 6-Hydroxy-3-Methyl-2-Oxo-1,2-Dihydroquinoline 6-Monooxygenase Activity
- 6-Hydroxynicotinate 3-Monooxygenase Activity
- Alpha-Pinene Monooxygenase
- Arachidonic Acid Epoxygenase Activity
- Bisphenol A Hydroxylase A Activity
- Branched-Chain Dodecylbenzene Sulfonate Monooxygenase Activity
- Carbon Disulfide Oxygenase Activity
- Chlorophenol 4-Monooxygenase Activity
- Dibenzothiophene Monooxygenase Activity
- Dimethyl Sulfide Monooxygenase Activity
- Enzyme Binding
- Heme Binding
- Iron Ion Binding
- Isobutylamine N-Hydroxylase Activity
- Limonene Monooxygenase Activity
- Monooxygenase Activity
- Oxidoreductase Activity
- Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Nad(P)H As One Donor, And Incorporation Of One Atom Of Oxygen
- Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen
- Oxygen Binding
- Phenanthrene 1,2-Monooxygenase Activity
- Phenanthrene 3,4-Monooxygenase Activity
- Phenanthrene 9,10-Monooxygenase Activity
- Phenylacetate Hydroxylase Activity
- Salicylate 5-Hydroxylase Activity
- Steroid Hydroxylase Activity
- Styrene Monooxygenase Activity
- Tetrahydrofuran Hydroxylase Activity
- Thalianol Hydroxylase Activity
- Tocotrienol Omega-Hydroxylase Activity
- Toluene 2-Monooxygenase Activity
- Toluene 3-Monooxygenase Activity
- Toluene 4-Monooxygenase Activity
- Toluene-4-Sulfonate Monooxygenase Activity
- Toluene-Sulfonate Methyl-Monooxygenase Activity
- Xylene Monooxygenase Activity
Biological Processes:
- Benzene Metabolic Process
- Carbon Tetrachloride Metabolic Process
- Drug Metabolic Process
- Epoxygenase P450 Pathway
- Halogenated Hydrocarbon Metabolic Process
- Heterocycle Metabolic Process
- Monoterpenoid Metabolic Process
- Oxidation-Reduction Process
- Response To Ethanol
- Response To Organonitrogen Compound
- Response To Ozone
- Steroid Metabolic Process
- Triglyceride Metabolic Process
- Xenobiotic Metabolic Process
Drug Bank:
- Clomifene
- Dalfampridine
- Acetaminophen
- Aldesleukin
- Almotriptan
- Alosetron
- Amitriptyline
- Antipyrine
- Azelastine
- Benzyl Alcohol
- Bifonazole
- Bromazepam
- Bupropion
- Caffeine
- Capsaicin
- Carbinoxamine
- Carvedilol
- Chlorzoxazone
- Cimetidine
- Citalopram
- Clevidipine
- Clofibrate
- Clonazepam
- Clozapine
- Colchicine
- Dacarbazine
- Dapsone
- Desipramine
- Dexfenfluramine
- Dexmedetomidine
- Dextromethorphan
- Diazepam
- Diclofenac
- Fingolimod
- Menadione
- Nicotinamide
- Rifampicin
- Disulfiram
- Econazole
- Enfuvirtide
- Estrone
- Ethanol
- Ethanolamine Oleate
- Ethosuximide
- Etoposide
- Felbamate
- Flunitrazepam
- Fluphenazine
- Flurazepam
- Fluvoxamine
- Folic Acid
- Glucosamine
- Halothane
- Hexobarbital
- Iloperidone
- Isoflurane
- Isoniazid
- Isosorbide Dinitrate
- Itraconazole
- Meprobamate
- Methazolamide
- Methotrimeprazine
- Methoxyflurane
- Metyrapone
- Mexiletine
- Miconazole
- Mitoxantrone
- Nicardipine
- Nifedipine
- Nilvadipine
- Nortriptyline
- Ondansetron
- Orphenadrine
- Oxaliplatin
- Paramethadione
- Phenelzine
- Pilocarpine
- Pimozide
- Proguanil
- Propofol
- Quinine
- Ritonavir
- Rufinamide
- S-Adenosylmethionine
- Selegiline
- Sevoflurane
- Streptozocin
- Sulfadiazine
- Sulfanilamide
- Tamoxifen
- Thalidomide
- Theobromine
- Thiopental
- Thioridazine
- Ticlopidine
- Tioconazole
- Trabectedin
- Trimethadione
- Ursodeoxycholic Acid
- Zafirlukast
- Zopiclone
- Nicotine
- Aminophylline
- Brompheniramine
- Chlorpromazine
- Clotrimazole
- Dexamethasone
- Diethylstilbestrol
- Enflurane
- Etoricoxib
- Fomepizole
- Imipramine
- Methimazole
- Midazolam
- Nitrazepam
- Phenobarbital
- Quinidine
- Sildenafil
- Theophylline
- Tranylcypromine