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  3. CYP2C18

CYP2C18 (Cytochrome P450 family 2 subfamily C member 18)

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The Function of CYP2C18

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

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Protein names

Recommended name:

Cytochrome P450 2C18

Short name:

CYPIIC18

Alternative name(s):

Cytochrome P450-6b/29c

CYP2C18 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS12772169 (CYP2C18) ??
  2. RS12777823 (CYP2C18) ??
  3. RS4986894 (CYP2C18) ??

Top Gene-Substance Interactions

Substances That Increase CYP2C18

Substances Interaction Organism Category

Substances That Decrease CYP2C18

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • NF-kappaB1

Gene Pathways:

  • Metabolic pathways
  • Metabolism
  • Linoleic acid metabolism
  • Metabolism of xenobiotics by cytochrome P450
  • Arachidonic acid metabolism
  • Retinol metabolism
  • Drug metabolism - cytochrome P450

Induction:

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Molecular Function:

  • Arachidonic Acid Epoxygenase Activity
  • Aromatase Activity
  • Heme Binding
  • Iron Ion Binding
  • Monooxygenase Activity
  • Oxygen Binding
  • Steroid Hydroxylase Activity

Biological Processes:

  • Epoxygenase P450 Pathway
  • Xenobiotic Metabolic Process

Drug Bank:

  • Aminophenazone
  • Vilazodone
  • Buprenorphine
  • Clobazam
  • Clotiazepam
  • Cyclophosphamide
  • Dapsone
  • Diazepam
  • Diclofenac
  • Diphenhydramine
  • Ifosfamide
  • Imipramine
  • Lidocaine
  • Methadone
  • Omeprazole
  • Pegvisomant
  • Perphenazine
  • Phenytoin
  • Propofol
  • Tolbutamide
  • Tretinoin
  • Troleandomycin
  • Valproic Acid
  • Warfarin
  • Antipyrine
  • Desipramine
  • Phenobarbital
  • Verapamil
  • Lansoprazole
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| flavoprotein-linked monooxygenase| microsomal monooxygenase| cyp2c| CPCI| CYP2C17| CYP2C19| CYP2C21| CYPIIC18| CYPIIC21| cytochrome P450 2C18| cytochrome P450 2C21| Cytochrome-P450-2C21| cytochrome P450-6B/29C| cytochrome P450 DM1-1| cytochrome P450, family 2, subfamily C, polypeptide 18| cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 17| cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 18| p450-6b/29c| p450iic17| (S)-mephenytoin hydroxylase associated cytochrome P450| unspecific monooxygenase| cyp2c18

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