The Function of CYP2C18
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
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Protein names
Recommended name:
Cytochrome P450 2C18Short name:
CYPIIC18Alternative name(s):
Cytochrome P450-6b/29c- RS12772169 (CYP2C18) ??
- RS12777823 (CYP2C18) ??
- RS4986894 (CYP2C18) ??
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Top Gene-Substance Interactions
Substances That Increase CYP2C18
| Substances | Interaction | Organism | Category |
Substances That Decrease CYP2C18
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Induction:
P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.
Molecular Function:
- Monooxygenase Activity
- Iron Ion Binding
- Arachidonic Acid Epoxygenase Activity
- Steroid Hydroxylase Activity
- Oxygen Binding
- Heme Binding
- Aromatase Activity
Biological Processes:
Drug Bank:
- Aminophenazone
- Vilazodone
- Buprenorphine
- Clobazam
- Clotiazepam
- Cyclophosphamide
- Dapsone
- Diazepam
- Diclofenac
- Diphenhydramine
- Ifosfamide
- Imipramine
- Lidocaine
- Methadone
- Omeprazole
- Pegvisomant
- Perphenazine
- Phenytoin
- Propofol
- Tolbutamide
- Tretinoin
- Troleandomycin
- Valproic Acid
- Warfarin
- Antipyrine
- Desipramine
- Phenobarbital
- Verapamil
- Lansoprazole