Summary of CYP2A6
This gene encodes an enzyme that helps catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. It is associated with higher susceptibility to tobacco addiction and lung cancer (R).
The Function of CYP2A6
Exhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide. Competent in the metabolic activation of aflatoxin B1. Constitutes the major nicotine C-oxidase. Acts as a 1,4-cineole 2-exo-monooxygenase. Possesses low phenacetin O-deethylation activity.
Protein names
Recommended name:
Cytochrome P450 2A6Short name:
CYPIIA6Alternative name(s):
1,4-cineole 2-exo-monooxygenaseCoumarin 7-hydroxylase
Cytochrome P450 IIA3
Cytochrome P450(I
- RS1801272 (CYP2A6) ??
- RS28399433 (CYP2A6) ??
- RS28399444 (CYP2A6) ??
- RS28399454 (CYP2A6) ??
- RS4105144 (CYP2A6) ??
- RS56113850 (CYP2A6) ??
- RS8102683 (CYP2A6) ??
To see your genotype, you should be logged in and have a file with your genotype uploaded.
Top Gene-Substance Interactions
CYP2A6 Interacts with These Diseases
| Disease | Score |
Substances That Increase CYP2A6
| Substances | Interaction | Organism | Category |
Substances That Decrease CYP2A6
| Substances | Interaction | Organism | Category |
Advanced Summary
From NCBI Gene: Tobacco addiction, susceptibility toLung cancerWarfarin response
From NCBI Gene: This gene, CYP2A6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to hydroxylate coumarin, and also metabolizes nicotine, aflatoxin B1, nitrosamines, and some pharmaceuticals. Individuals with certain allelic variants are said to have a poor metabolizer phenotype, meaning they do not efficiently metabolize coumarin or nicotine . This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. The gene was formerly referred to as CYP2A3; however, it has been renamed CYP2A6. [provided by RefSeq, Jul 2008] From UniProt: Exhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide. Competent in the metabolic activation of aflatoxin B1. Constitutes the major nicotine C-oxidase. Acts as a 1,4-cineole 2-exo-monooxygenase. Possesses low phenacetin O-deethylation activity.
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Liver.
Gene Pathways:
Induction:
By phenobarbital and dexamethasone.
Molecular Function:
- Arachidonic Acid Epoxygenase Activity
- Coumarin 7-Hydroxylase Activity
- Enzyme Binding
- Heme Binding
- Iron Ion Binding
- Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen
- Steroid Hydroxylase Activity
Biological Processes:
- Coumarin Catabolic Process
- Coumarin Metabolic Process
- Drug Metabolic Process
- Epoxygenase P450 Pathway
- Exogenous Drug Catabolic Process
- Steroid Metabolic Process
Drug Bank:
- Ezogabine
- Arformoterol
- Clomifene
- Dapagliflozin
- Dronabinol
- Acetaminophen
- Amiodarone
- Amlodipine
- Amobarbital
- Antipyrine
- Azelastine
- Azithromycin
- Buprenorphine
- Bupropion
- Cinnarizine
- Cisapride
- Clofibrate
- Clotrimazole
- Clozapine
- Desipramine
- Dexamethasone
- Dexfenfluramine
- Diethylstilbestrol
- Formoterol
- Menadione
- Rifampicin
- Fluorouracil
- Flurazepam
- Halothane
- Ifosfamide
- Isoniazid
- Ketoconazole
- Lidocaine
- Lorcaserin
- Memantine
- Methimazole
- Methoxyflurane
- Metyrapone
- Miconazole
- Montelukast
- Nevirapine
- Nifedipine
- Nilvadipine
- Norfloxacin
- Pentobarbital
- Phenobarbital
- Prednisolone
- Progesterone
- Propofol
- Rosiglitazone
- Selegiline
- Sevoflurane
- Tamoxifen
- Tranylcypromine
- Tretinoin
- Troleandomycin
- Valproic Acid
- Vortioxetine
- Zidovudine
- Flunarizine
- Eletriptan
- Amphetamine
- Chlorzoxazone
- Cyclophosphamide
- Flunitrazepam
- Fomepizole
- Letrozole
- Methoxsalen
- Pilocarpine
- Sulfaphenazole
- Nicotine