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  3. CYP2A6

CYP2A6 (Cytochrome P450 family 2 subfamily A member 6)

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Summary of CYP2A6

This gene encodes an enzyme that helps catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. It is associated with higher susceptibility to tobacco addiction and lung cancer (R).

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The Function of CYP2A6

Exhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide. Competent in the metabolic activation of aflatoxin B1. Constitutes the major nicotine C-oxidase. Acts as a 1,4-cineole 2-exo-monooxygenase. Possesses low phenacetin O-deethylation activity.

Protein names

Recommended name:

Cytochrome P450 2A6

Short name:

CYPIIA6

Alternative name(s):

1,4-cineole 2-exo-monooxygenase
Coumarin 7-hydroxylase
Cytochrome P450 IIA3
Cytochrome P450(I

CYP2A6 SNPs

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  1. RS1801272 (CYP2A6) ??
  2. RS28399433 (CYP2A6) ??
  3. RS28399444 (CYP2A6) ??
  4. RS28399454 (CYP2A6) ??
  5. RS4105144 (CYP2A6) ??
  6. RS56113850 (CYP2A6) ??
  7. RS8102683 (CYP2A6) ??

Top Gene-Substance Interactions

CYP2A6 Interacts with These Diseases

Disease Score

Substances That Increase CYP2A6

Substances Interaction Organism Category

Substances That Decrease CYP2A6

Substances Interaction Organism Category

Advanced Summary

     From NCBI Gene: Tobacco addiction, susceptibility toLung cancerWarfarin response

     From NCBI Gene: This gene, CYP2A6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to hydroxylate coumarin, and also metabolizes nicotine, aflatoxin B1, nitrosamines, and some pharmaceuticals. Individuals with certain allelic variants are said to have a poor metabolizer phenotype, meaning they do not efficiently metabolize coumarin or nicotine . This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. The gene was formerly referred to as CYP2A3; however, it has been renamed CYP2A6. [provided by RefSeq, Jul 2008] From UniProt: Exhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide. Competent in the metabolic activation of aflatoxin B1. Constitutes the major nicotine C-oxidase. Acts as a 1,4-cineole 2-exo-monooxygenase. Possesses low phenacetin O-deethylation activity.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • p53
  • C/EBPbeta

Tissue specificity:

Liver.

Gene Pathways:

  • Metabolic pathways
  • Metabolism
  • Retinol metabolism
  • Drug metabolism - cytochrome P450
  • Caffeine metabolism
  • Drug metabolism - other enzymes

Induction:

By phenobarbital and dexamethasone.

Molecular Function:

  • Arachidonic Acid Epoxygenase Activity
  • Coumarin 7-Hydroxylase Activity
  • Enzyme Binding
  • Heme Binding
  • Iron Ion Binding
  • Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen
  • Steroid Hydroxylase Activity

Biological Processes:

  • Coumarin Catabolic Process
  • Coumarin Metabolic Process
  • Drug Metabolic Process
  • Epoxygenase P450 Pathway
  • Exogenous Drug Catabolic Process
  • Steroid Metabolic Process

Drug Bank:

  • Ezogabine
  • Arformoterol
  • Clomifene
  • Dapagliflozin
  • Dronabinol
  • Acetaminophen
  • Amiodarone
  • Amlodipine
  • Amobarbital
  • Antipyrine
  • Azelastine
  • Azithromycin
  • Buprenorphine
  • Bupropion
  • Cinnarizine
  • Cisapride
  • Clofibrate
  • Clotrimazole
  • Clozapine
  • Desipramine
  • Dexamethasone
  • Dexfenfluramine
  • Diethylstilbestrol
  • Formoterol
  • Menadione
  • Rifampicin
  • Fluorouracil
  • Flurazepam
  • Halothane
  • Ifosfamide
  • Isoniazid
  • Ketoconazole
  • Lidocaine
  • Lorcaserin
  • Memantine
  • Methimazole
  • Methoxyflurane
  • Metyrapone
  • Miconazole
  • Montelukast
  • Nevirapine
  • Nifedipine
  • Nilvadipine
  • Norfloxacin
  • Pentobarbital
  • Phenobarbital
  • Prednisolone
  • Progesterone
  • Propofol
  • Rosiglitazone
  • Selegiline
  • Sevoflurane
  • Tamoxifen
  • Tranylcypromine
  • Tretinoin
  • Troleandomycin
  • Valproic Acid
  • Vortioxetine
  • Zidovudine
  • Flunarizine
  • Eletriptan
  • Amphetamine
  • Chlorzoxazone
  • Cyclophosphamide
  • Flunitrazepam
  • Fomepizole
  • Letrozole
  • Methoxsalen
  • Pilocarpine
  • Sulfaphenazole
  • Nicotine
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| flavoprotein-linked monooxygenase| xenobiotic monooxygenase| 1,4-cineole 2-exo-monooxygenase| coumarin 7-hydroxylase| CPA6| CYP2A| cyp2a13| CYP2A3| CYPIIA6| cytochrome P450 2A6| cytochrome P450, family 2, subfamily A, polypeptide 6| cytochrome P450(I)| cytochrome P450 IIA3| cytochrome P450, subfamily IIA (phenobarbital-inducible), polypeptide 6| P450C2A| P450PB| cyp2a6

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