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  3. CYP26B1

CYP26B1 (Cytochrome P450 family 26 subfamily B member 1)

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The Function of CYP26B1

Has also a significant activity in oxidation of tazarotenic acid and may therefore metabolize that xenobiotic in vivo.

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Protein names

Recommended name:

Cytochrome P450 26B1

Alternative name(s):

Cytochrome P450 26A2
Cytochrome P450 retinoic acid-inactivating 2
Cytochrome P450RAI-2
Retinoic acid-metabolizing cytochrome

CYP26B1 SNPs

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  1. RS3768644 (CYP26B1) ??

Top Gene-Substance Interactions

CYP26B1 Interacts with These Diseases

Disease Score

Substances That Increase CYP26B1

Substances Interaction Organism Category

Substances That Decrease CYP26B1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • Brachyury

Tissue specificity:

Highly expressed in brain, particularly in the cerebellum and pons.

Gene Pathways:

  • Metabolism
  • Retinol metabolism

Induction:

By retinoic acid.

Molecular Function:

  • Heme Binding
  • Iron Ion Binding
  • Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Nad(P)H As One Donor, And Incorporation Of One Atom Of Oxygen
  • Retinoic Acid 4-Hydroxylase Activity
  • Retinoic Acid Binding

Biological Processes:

  • Bone Morphogenesis
  • Cell Fate Determination
  • Cellular Response To Retinoic Acid
  • Cornification
  • Embryonic Limb Morphogenesis
  • Establishment Of Skin Barrier
  • Establishment Of T Cell Polarity
  • Inflammatory Response
  • Male Meiosis
  • Negative Regulation Of Retinoic Acid Receptor Signaling Pathway
  • Oxidation-Reduction Process
  • Positive Regulation Of Gene Expression
  • Positive Regulation Of Tongue Muscle Cell Differentiation
  • Proximal/Distal Pattern Formation
  • Regulation Of T Cell Differentiation
  • Retinoic Acid Catabolic Process
  • Retinoic Acid Receptor Signaling Pathway
  • Spermatogenesis
  • Tongue Morphogenesis
  • Vitamin Metabolic Process
  • Xenobiotic Metabolic Process
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| retinoic acid hydroxylase| retinoic acid-metabolizing cytochrome| CP26| cyp26a2| cytochrome P450 26B1| cytochrome P450, 26, retinoic acid B1| cytochrome P450 family 26 subfamily A member 1| cytochrome P450, family 26, subfamily b, polypeptide 1| cytochrome P450RAI-2| cytochrome P450 retinoic acid-inactivating 2| cytochrome P450 retinoid metabolizing protein| cytochrome P450, subfamily XXVIB, polypeptide 1| dol| fc21d03| p450rai-2| P450RAI2| retinoic acid B1| RHFCA| stocksteif| cyp26b1

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