The Function of CYP26B1
Has also a significant activity in oxidation of tazarotenic acid and may therefore metabolize that xenobiotic in vivo.
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Protein names
Recommended name:
Cytochrome P450 26B1Alternative name(s):
Cytochrome P450 26A2Cytochrome P450 retinoic acid-inactivating 2
Cytochrome P450RAI-2
Retinoic acid-metabolizing cytochrome
- RS3768644 (CYP26B1) ??
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Top Gene-Substance Interactions
CYP26B1 Interacts with These Diseases
| Disease | Score |
Substances That Increase CYP26B1
| Substances | Interaction | Organism | Category |
Substances That Decrease CYP26B1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Highly expressed in brain, particularly in the cerebellum and pons.
Gene Pathways:
Induction:
By retinoic acid.
Molecular Function:
- Heme Binding
- Iron Ion Binding
- Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Nad(P)H As One Donor, And Incorporation Of One Atom Of Oxygen
- Retinoic Acid 4-Hydroxylase Activity
- Retinoic Acid Binding
Biological Processes:
- Bone Morphogenesis
- Cell Fate Determination
- Cellular Response To Retinoic Acid
- Cornification
- Embryonic Limb Morphogenesis
- Establishment Of Skin Barrier
- Establishment Of T Cell Polarity
- Inflammatory Response
- Male Meiosis
- Negative Regulation Of Retinoic Acid Receptor Signaling Pathway
- Oxidation-Reduction Process
- Positive Regulation Of Gene Expression
- Positive Regulation Of Tongue Muscle Cell Differentiation
- Proximal/Distal Pattern Formation
- Regulation Of T Cell Differentiation
- Retinoic Acid Catabolic Process
- Retinoic Acid Receptor Signaling Pathway
- Spermatogenesis
- Tongue Morphogenesis
- Vitamin Metabolic Process
- Xenobiotic Metabolic Process