The Function of CYP26A1
Has also a significant activity in oxidation of tazarotenic acid and may therefore metabolize that xenobiotic in vivo.
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Protein names
Recommended name:
Cytochrome P450 26A1Alternative name(s):
Cytochrome P450 retinoic acid-inactivating 1Cytochrome P450RAI
hP450RAI
Retinoic acid 4-hydroxylase
Retinoic acid-metabolizing cytochrome
- RS2068888 (CYP26A1) ??
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Top Gene-Substance Interactions
CYP26A1 Interacts with These Diseases
| Disease | Score |
Substances That Increase CYP26A1
| Substances | Interaction | Organism | Category |
Substances That Decrease CYP26A1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Highest levels in adult liver, heart, pituitary gland, adrenal gland, placenta and regions of the brain.
Gene Pathways:
Induction:
By retinoic acid.
Molecular Function:
- Heme Binding
- Iron Ion Binding
- Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Nad(P)H As One Donor, And Incorporation Of One Atom Of Oxygen
- Oxygen Binding
- Retinoic Acid 4-Hydroxylase Activity
- Retinoic Acid Binding
Biological Processes:
- Negative Regulation Of Retinoic Acid Receptor Signaling Pathway
- Retinoic Acid Catabolic Process
- Retinoic Acid Metabolic Process
- Vitamin Metabolic Process
- Xenobiotic Metabolic Process