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  3. CYP26A1

CYP26A1 (Cytochrome P450 family 26 subfamily A member 1)

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The Function of CYP26A1

Has also a significant activity in oxidation of tazarotenic acid and may therefore metabolize that xenobiotic in vivo.

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Protein names

Recommended name:

Cytochrome P450 26A1

Alternative name(s):

Cytochrome P450 retinoic acid-inactivating 1
Cytochrome P450RAI
hP450RAI
Retinoic acid 4-hydroxylase
Retinoic acid-metabolizing cytochrome

CYP26A1 SNPs

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  1. RS2068888 (CYP26A1) ??

Top Gene-Substance Interactions

CYP26A1 Interacts with These Diseases

Disease Score

Substances That Increase CYP26A1

Substances Interaction Organism Category

Substances That Decrease CYP26A1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • Egr-1

Tissue specificity:

Highest levels in adult liver, heart, pituitary gland, adrenal gland, placenta and regions of the brain.

Gene Pathways:

  • Metabolism
  • Retinol metabolism

Induction:

By retinoic acid.

Molecular Function:

  • Heme Binding
  • Iron Ion Binding
  • Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Nad(P)H As One Donor, And Incorporation Of One Atom Of Oxygen
  • Oxygen Binding
  • Retinoic Acid 4-Hydroxylase Activity
  • Retinoic Acid Binding

Biological Processes:

  • Negative Regulation Of Retinoic Acid Receptor Signaling Pathway
  • Retinoic Acid Catabolic Process
  • Retinoic Acid Metabolic Process
  • Vitamin Metabolic Process
  • Xenobiotic Metabolic Process

Drug Bank:

  • Ketoconazole
  • Vitamin A
  • Acitretin
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| RACE| cp26| CYP26| CYP26A| cytochrome P450 26| cytochrome P450 26A1| cytochrome P450, 26, retinoic acid| cytochrome P450, 26, retinoic acid A1| cytochrome P450 CYP26A1| cytochrome P450, family 26, subfamily a, polypeptide 1| cytochrome P450RAI| cytochrome P450 retinoic acid hydroxylase| cytochrome P450 retinoic acid-inactivating 1| cytochrome P450, subfamily XXVIA, polypeptide 1| etID42255.12| gir| giraffe| hP450RAI| P450RA| p450rai| p450rai1| P450, retinoic acid-inactivating, 1| RAH| retinoic acid 4-hydroxylase| retinoic acid converting enzyme| retinoic acid-degrading enzyme CYP26| retinoic acid hydrolase| retinoic acid hydroxylase| retinoic acid-metabolizing cytochrome| xCYP26| XCYP26A1| cyp26a1

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