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  3. CYP24A1

CYP24A1 (Cytochrome P450 family 24 subfamily A member 1)

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Summary of CYP24A1

CYP24A1 encodes for an enzyme that catalyzes reactions involved in drug metabolism and synthesis of cholesterol, steroids, and other lipids. It regulates the level of active vitamin D3, so it plays a role in calcium homeostasis and the vitamin D endocrine system. Catalyzes the NADPH-dependent 24-hydroxylation of calcidiol (25-hydroxyvitamin D3) and calcitriol (1, 25-dihydroxyvitamin D3) into inactive metabolites. The enzyme can perform up to 6 rounds of hydroxylation of calcitriol leading to calcitroic acid.

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Protein names

Recommended name:

Cytochrome P450 family 24 subfamily A member 1

Alternative name(s):

1,25-dihydroxyvitamin D3 24-hydroxylase, mitochondrial
Vitamin D3 24-hydroxylase
Cytochrome P450 24A1
Cytochrome P450-CC24

CYP24A1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS1570669 (CYP24A1) ??
  2. RS2248359 (CYP24A1) ??
  3. RS2296241 (CYP24A1) ??
  4. RS4809957 (CYP24A1) ??
  5. RS6064045 (CYP24A1) ??
  6. RS927650 (CYP24A1) ??

Top Gene-Substance Interactions

CYP24A1 Interacts with These Diseases

Disease Score

Substances That Increase CYP24A1

Substances Interaction Organism Category

Substances That Decrease CYP24A1

Substances Interaction Organism Category

Advanced Summary

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This mitochondrial protein initiates the degradation of 1,25-dihydroxyvitamin D3, the physiologically active form of vitamin D3, by hydroxylation of the side chain. In regulating the level of vitamin D3, this enzyme plays a role in calcium homeostasis and the vitamin D endocrine system. Alternatively, spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] From UniProt: Has a role in maintaining calcium homeostasis. Catalyzes the NADPH-dependent 24-hydroxylation of calcidiol (25-hydroxyvitamin D(3)) and calcitriol (1-alpha,25-dihydroxyvitamin D(3)). The enzyme can perform up to 6 rounds of hydroxylation of calcitriol leading to calcitroic acid. It also shows 23-hydroxylating activity leading to 1-alpha,25-dihydroxyvitamin D(3)-26,23-lactone as end product.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • GR
  • GR-alpha
  • GR-beta
  • AP-1
  • c-Jun
  • NF-kappaB1
  • C/EBPalpha
  • E2F-1

Gene Pathways:

  • Metabolism
  • Steroid hormones

Molecular Function:

  • 1-Alpha,25-Dihydroxyvitamin D3 24-Hydroxylase Activity
  • 25-Hydroxycholecalciferol-24-Hydroxylase Activity
  • Heme Binding
  • Iron Ion Binding
  • Oxidoreductase Activity

Biological Processes:

  • Osteoblast Differentiation
  • Oxidation-Reduction Process
  • Response To Vitamin D
  • Vitamin D Catabolic Process
  • Vitamin D Metabolic Process
  • Vitamin D Receptor Signaling Pathway
  • Vitamin Metabolic Process

Drug Bank:

  • Calcidiol
  • Calcipotriol
  • Corticotropin
  • Ergocalciferol
  • Paricalcitol
  • Calcitriol
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| 1,25-@dihydroxyvitamin D3 24-hydroxylase| 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial| 24-OHase| 24R-Ohase| 25-hydroxyvitamin D-24-hydroxylase| 25-hydroxyvitamin D3 24-hydroxylase| 25-hydroxyvitamin D3-24-hydroxylase| 25-hydroxyvitaminD324-hydroxylase| CP24| CP450CC24| CYP24| cyp24a1l| cytochrome P450, 24| cytochrome P450, 24a1| cytochrome P450 24A1| cytochrome P450-CC24| cytochrome P450, family 24, subfamily A, polypeptide 1| cytochrome P450, family 24, subfamily A, polypeptide 1, like| cytochrome P450, subfamily 24| cytochrome P450, subfamily XXIV (vitamin D 24-hydroxylase)| Cytochrom P450 (25-hydroxyvitamin D24-hydroxylase)| exo-mitochondrial protein| HCAI| HCINF1| P450-CC24| vitamin D 24-hydroxylase| vitamin D(3) 24-hydroxylase| VITD12| cyp24a1

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