Summary of CYP24A1
CYP24A1 encodes for an enzyme that catalyzes reactions involved in drug metabolism and synthesis of cholesterol, steroids, and other lipids. It regulates the level of active vitamin D3, so it plays a role in calcium homeostasis and the vitamin D endocrine system. Catalyzes the NADPH-dependent 24-hydroxylation of calcidiol (25-hydroxyvitamin D3) and calcitriol (1, 25-dihydroxyvitamin D3) into inactive metabolites. The enzyme can perform up to 6 rounds of hydroxylation of calcitriol leading to calcitroic acid.
Protein names
Recommended name:
Cytochrome P450 family 24 subfamily A member 1Alternative name(s):
1,25-dihydroxyvitamin D3 24-hydroxylase, mitochondrialVitamin D3 24-hydroxylase
Cytochrome P450 24A1
Cytochrome P450-CC24
- RS1570669 (CYP24A1) ??
- RS2248359 (CYP24A1) ??
- RS2296241 (CYP24A1) ??
- RS4809957 (CYP24A1) ??
- RS6064045 (CYP24A1) ??
- RS927650 (CYP24A1) ??
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Top Gene-Substance Interactions
CYP24A1 Interacts with These Diseases
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Substances That Increase CYP24A1
| Substances | Interaction | Organism | Category |
Substances That Decrease CYP24A1
| Substances | Interaction | Organism | Category |
Advanced Summary
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This mitochondrial protein initiates the degradation of 1,25-dihydroxyvitamin D3, the physiologically active form of vitamin D3, by hydroxylation of the side chain. In regulating the level of vitamin D3, this enzyme plays a role in calcium homeostasis and the vitamin D endocrine system. Alternatively, spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] From UniProt: Has a role in maintaining calcium homeostasis. Catalyzes the NADPH-dependent 24-hydroxylation of calcidiol (25-hydroxyvitamin D(3)) and calcitriol (1-alpha,25-dihydroxyvitamin D(3)). The enzyme can perform up to 6 rounds of hydroxylation of calcitriol leading to calcitroic acid. It also shows 23-hydroxylating activity leading to 1-alpha,25-dihydroxyvitamin D(3)-26,23-lactone as end product.
Conditions with Increased Gene Activity
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Conditions with Decreased Gene Activity
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
- Iron Ion Binding
- 25-Hydroxycholecalciferol-24-Hydroxylase Activity
- Oxidoreductase Activity
- Heme Binding
- 1-Alpha,25-Dihydroxyvitamin D3 24-Hydroxylase Activity
Biological Processes:
- Osteoblast Differentiation
- Vitamin Metabolic Process
- Response To Vitamin D
- Vitamin D Metabolic Process
- Vitamin D Catabolic Process
- Oxidation-Reduction Process
- Vitamin D Receptor Signaling Pathway
Drug Bank:
- Calcidiol
- Calcipotriol
- Corticotropin
- Ergocalciferol
- Paricalcitol
- Calcitriol