Summary of CYP1A1
CYP1A1 encodes for an enzyme (cytochrome P450 family 1 subfamily A member 1) and catalyzes reactions involved in drug metabolism and synthesis of cholesterol, steroids, and other lipids (R).
It is associated with lung cancer risk because it can metabolize hydrocarbons from cigarette smoke to carcinogens (R).
It is also associated with breast cancer, leukemia, and colon cancer (R, R, R).
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Protein names
Recommended name:
Cytochrome P450 1A1Short name:
CYPIA1Alternative name(s):
Cytochrome P450 form 6Cytochrome P450-C
Cytochrome P450-P1
- RS1048943 (CYP1A1) ??
- RS1799814 (CYP1A1) ??
- RS2470893 (CYP1A1) ??
- RS2472297 (CYP1A1) ??
- RS2472299 (CYP1A1) ??
- RS2606345 (CYP1A1) ??
- RS4646421 (CYP1A1) ??
- RS4646422 (CYP1A1) ??
- RS4986883 (CYP1A1) ??
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Top Gene-Substance Interactions
CYP1A1 Interacts with These Diseases
| Disease | Score |
Substances That Increase CYP1A1
| Substances | Interaction | Organism | Category |
Substances That Decrease CYP1A1
| Substances | Interaction | Organism | Category |
Advanced Summary
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Lung, lymphocytes and placenta.
Gene Pathways:
Induction:
By 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).
Molecular Function:
- Aromatase Activity
- Demethylase Activity
- Estrogen 16-Alpha-Hydroxylase Activity
- Flavonoid 3'-Monooxygenase Activity
- Heme Binding
- Iron Ion Binding
- Monooxygenase Activity
- Oxidoreductase Activity
- Oxidoreductase Activity, Acting On Diphenols And Related Substances As Donors
- Oxygen Binding
- Vitamin D 24-Hydroxylase Activity
- Steroid Hydroxylase Activity
Biological Processes:
- 9-Cis-Retinoic Acid Biosynthetic Process
- Aging
- Amine Metabolic Process
- Camera-Type Eye Development
- Cell Proliferation
- Cellular Response To Organic Cyclic Compound
- Coumarin Metabolic Process
- Dibenzo-P-Dioxin Catabolic Process
- Digestive Tract Development
- Drug Metabolic Process
- Embryo Development Ending In Birth Or Egg Hatching
- Epoxygenase P450 Pathway
- Ethylene Metabolic Process
- Flavonoid Metabolic Process
- Hepatocyte Differentiation
- Hydrogen Peroxide Biosynthetic Process
- Insecticide Metabolic Process
- Lipid Hydroxylation
- Maternal Process Involved In Parturition
- Omega-Hydroxylase P450 Pathway
- Oxidation-Reduction Process
- Porphyrin-Containing Compound Metabolic Process
- Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
- Response To Antibiotic
- Response To Arsenic-Containing Substance
- Response To Food
- Response To Herbicide
- Response To Hyperoxia
- Response To Hypoxia
- Response To Immobilization Stress
- Response To Iron(Iii) Ion
- Response To Lipopolysaccharide
- Response To Nematode
- Response To Virus
- Response To Vitamin A
- Response To Wounding
- Steroid Metabolic Process
- Vitamin D Metabolic Process
Drug Bank:
- Clobetasol Propionate
- Clomifene
- Dapagliflozin
- Dronabinol
- Erlotinib
- Isoprenaline
- Menadione
- Albendazole
- Amiodarone
- Amlodipine
- Amodiaquine
- Azelastine
- Benzyl Alcohol
- Bezafibrate
- Bortezomib
- Caffeine
- Chloroquine
- Chlorzoxazone
- Cholecalciferol
- Cinnarizine
- Clenbuterol
- Clonidine
- Clozapine
- Dacarbazine
- Dasatinib
- Debrisoquin
- Dexamethasone
- Dexmedetomidine
- Diclofenac
- Dicyclomine
- Estradiol
- Estrone
- Ethanol
- Fluorescein
- Flutamide
- Fluvastatin
- Fluvoxamine
- Granisetron
- Haloperidol
- Itraconazole
- Ketoconazole
- Lorcaserin
- Melatonin
- Methoxsalen
- Nifedipine
- Norfloxacin
- Omeprazole
- Nicotine
- Lansoprazole
- Ouabain
- Oxaliplatin
- Phenobarbital
- Prazosin
- Primaquine
- Progesterone
- Propofol
- Quinidine
- Quinine
- Rabeprazole
- Riluzole
- Romidepsin
- Sildenafil
- Streptozocin
- Sulindac
- Testosterone
- Thalidomide
- Theophylline
- Thiabendazole
- Ticlopidine
- Toremifene
- Vitamin A
- Warfarin
- Pyridoxine
- Acetaminophen
- Arsenic Trioxide
- Carvedilol
- Clofibrate
- Daunorubicin
- Flunarizine
- Gefitinib
- Mebendazole
- Nitroprusside
- Pentamidine
- Propranolol
- Riociguat
- Tamoxifen
- Tretinoin