• Navigation
  • Register My DNA Kit
  • Features
  • Pricing
  • FAQ
  • About
  • Labs
  • Login
  • Get started
  1. Home
  2. Genes
  3. CYP1A1

CYP1A1 (Cytochrome P450 family 1 subfamily A member 1)

Loading...

Summary of CYP1A1

CYP1A1 encodes for an enzyme (cytochrome P450 family 1 subfamily A member 1) and catalyzes reactions involved in drug metabolism and synthesis of cholesterol, steroids, and other lipids (R). 

It is associated with lung cancer risk because it can metabolize hydrocarbons from cigarette smoke to carcinogens (R).

It is also associated with breast cancer, leukemia, and colon cancer (R, R, R). 

0 users want this gene increased, 0 users want it decreased

Protein names

Recommended name:

Cytochrome P450 1A1

Short name:

CYPIA1

Alternative name(s):

Cytochrome P450 form 6
Cytochrome P450-C
Cytochrome P450-P1

CYP1A1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS1048943 (CYP1A1) ??
  2. RS1799814 (CYP1A1) ??
  3. RS2470893 (CYP1A1) ??
  4. RS2472297 (CYP1A1) ??
  5. RS2472299 (CYP1A1) ??
  6. RS2606345 (CYP1A1) ??
  7. RS4646421 (CYP1A1) ??
  8. RS4646422 (CYP1A1) ??
  9. RS4986883 (CYP1A1) ??

Top Gene-Substance Interactions

CYP1A1 Interacts with These Diseases

Disease Score

Substances That Increase CYP1A1

Substances Interaction Organism Category

Substances That Decrease CYP1A1

Substances Interaction Organism Category

Advanced Summary

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • p53
  • AhR
  • Arnt
  • C/EBPbeta
  • C/EBPalpha
  • c-Fos
  • Fra-1

Tissue specificity:

Lung, lymphocytes and placenta.

Gene Pathways:

  • Metabolic pathways
  • Metabolism
  • Steroid hormone biosynthesis
  • Tryptophan metabolism
  • Metabolism of xenobiotics by cytochrome P450
  • Retinol metabolism

Induction:

By 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).

Molecular Function:

  • Aromatase Activity
  • Demethylase Activity
  • Estrogen 16-Alpha-Hydroxylase Activity
  • Flavonoid 3'-Monooxygenase Activity
  • Heme Binding
  • Iron Ion Binding
  • Monooxygenase Activity
  • Oxidoreductase Activity
  • Oxidoreductase Activity, Acting On Diphenols And Related Substances As Donors
  • Oxygen Binding
  • Vitamin D 24-Hydroxylase Activity
  • Steroid Hydroxylase Activity

Biological Processes:

  • 9-Cis-Retinoic Acid Biosynthetic Process
  • Aging
  • Amine Metabolic Process
  • Camera-Type Eye Development
  • Cell Proliferation
  • Cellular Response To Organic Cyclic Compound
  • Coumarin Metabolic Process
  • Dibenzo-P-Dioxin Catabolic Process
  • Digestive Tract Development
  • Drug Metabolic Process
  • Embryo Development Ending In Birth Or Egg Hatching
  • Epoxygenase P450 Pathway
  • Ethylene Metabolic Process
  • Flavonoid Metabolic Process
  • Hepatocyte Differentiation
  • Hydrogen Peroxide Biosynthetic Process
  • Insecticide Metabolic Process
  • Lipid Hydroxylation
  • Maternal Process Involved In Parturition
  • Omega-Hydroxylase P450 Pathway
  • Oxidation-Reduction Process
  • Porphyrin-Containing Compound Metabolic Process
  • Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
  • Response To Antibiotic
  • Response To Arsenic-Containing Substance
  • Response To Food
  • Response To Herbicide
  • Response To Hyperoxia
  • Response To Hypoxia
  • Response To Immobilization Stress
  • Response To Iron(Iii) Ion
  • Response To Lipopolysaccharide
  • Response To Nematode
  • Response To Virus
  • Response To Vitamin A
  • Response To Wounding
  • Steroid Metabolic Process
  • Vitamin D Metabolic Process

Drug Bank:

  • Clobetasol Propionate
  • Clomifene
  • Dapagliflozin
  • Dronabinol
  • Erlotinib
  • Isoprenaline
  • Menadione
  • Albendazole
  • Amiodarone
  • Amlodipine
  • Amodiaquine
  • Azelastine
  • Benzyl Alcohol
  • Bezafibrate
  • Bortezomib
  • Caffeine
  • Chloroquine
  • Chlorzoxazone
  • Cholecalciferol
  • Cinnarizine
  • Clenbuterol
  • Clonidine
  • Clozapine
  • Dacarbazine
  • Dasatinib
  • Debrisoquin
  • Dexamethasone
  • Dexmedetomidine
  • Diclofenac
  • Dicyclomine
  • Estradiol
  • Estrone
  • Ethanol
  • Fluorescein
  • Flutamide
  • Fluvastatin
  • Fluvoxamine
  • Granisetron
  • Haloperidol
  • Itraconazole
  • Ketoconazole
  • Lorcaserin
  • Melatonin
  • Methoxsalen
  • Nifedipine
  • Norfloxacin
  • Omeprazole
  • Nicotine
  • Lansoprazole
  • Ouabain
  • Oxaliplatin
  • Phenobarbital
  • Prazosin
  • Primaquine
  • Progesterone
  • Propofol
  • Quinidine
  • Quinine
  • Rabeprazole
  • Riluzole
  • Romidepsin
  • Sildenafil
  • Streptozocin
  • Sulindac
  • Testosterone
  • Thalidomide
  • Theophylline
  • Thiabendazole
  • Ticlopidine
  • Toremifene
  • Vitamin A
  • Warfarin
  • Pyridoxine
  • Acetaminophen
  • Arsenic Trioxide
  • Carvedilol
  • Clofibrate
  • Daunorubicin
  • Flunarizine
  • Gefitinib
  • Mebendazole
  • Nitroprusside
  • Pentamidine
  • Propranolol
  • Riociguat
  • Tamoxifen
  • Tretinoin
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| AHH| ahrr| flavoprotein-linked monooxygenase| microsomal monooxygenase| aromatic compound inducible| aryl hydrocarbon hydroxylase| CP11| cyp1| CYP1A| Cyp1a2| CYP1A4| CYP1A5| Cyp45c| Cypc45c| CYPIA1| CYPIA4| CYPIA5| cytochrome 1A1| cytochrome P1-450| cytochrome P1-450, dioxin-inducible| cytochrome P450| cytochrome P450, 1a1| cytochrome P4501A1| cytochrome P450 1A1| cytochrome P450, 1a1, aromatic compound inducible| cytochrome P450 1A4| cytochrome P450 1A5| cytochrome P450-C| cytochrome P450 CYP1A1| cytochrome P450, family 1, subfamily a, polypeptide 1| cytochrome P450 family 1 subfamily a polypeptide 2| cytochrome P450, family 1, subfamily A, polypeptide 4| cytochrome P450 form 6| cytochrome P450MT2| cytochrome P450-P1| cytochrome P450 subfamily I (aromatic compound-inducible) member A1 (C6 form c) (C6 form c)| cytochrome P450, subfamily I (aromatic compound-inducible), member A1 (C6, form c) (C6, form c)| cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 1| cytochrome P450 subfamily I, polypeptide 1| cytochrome P450 TCDDAA| cytochrome P450 TCDDAHH| DAH1| dioxin-inducible| p1-450| P450-1| P450-C| p450dx| P450form6| P-450MC| P450MT2| xenobiotic monooxygenase| cyp1a1

Policies

  • Terms of Service
  • Platform Consent
  • Privacy Policy
  • Disclaimer

About

  • Customer Support
  • Our Team
  • Affiliate Program

Navigation

  • Homepage
  • DNA Wellness Reports
  • Personalized Genetics Blog
  • Register your DNA Test Kit
  • Login
  • Careers
GET STARTED
  • SelfDecode is a personalized health report service, which enables users to obtain detailed information and reports based on their genome. SelfDecode does not treat, diagnose or cure any conditions, but is for informational and educational purposes alone.
SelfDecode © 2021 All Rights Reserved