Summary of CYP1A1
CYP1A1 encodes for an enzyme (cytochrome P450 family 1 subfamily A member 1) and catalyzes reactions involved in drug metabolism and synthesis of cholesterol, steroids, and other lipids (R).
It is associated with lung cancer risk because it can metabolize hydrocarbons from cigarette smoke to carcinogens (R).
It is also associated with breast cancer, leukemia, and colon cancer (R, R, R).
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Protein names
Recommended name:
Cytochrome P450 1A1Short name:
CYPIA1Alternative name(s):
Cytochrome P450 form 6Cytochrome P450-C
Cytochrome P450-P1
- RS1048943 (CYP1A1) ??
- RS1799814 (CYP1A1) ??
- RS2470893 (CYP1A1) ??
- RS2472297 (CYP1A1) ??
- RS2472299 (CYP1A1) ??
- RS2606345 (CYP1A1) ??
- RS4646421 (CYP1A1) ??
- RS4646422 (CYP1A1) ??
- RS4986883 (CYP1A1) ??
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Top Gene-Substance Interactions
CYP1A1 Interacts with These Diseases
| Disease | Score |
Substances That Increase CYP1A1
| Substances | Interaction | Organism | Category |
Substances That Decrease CYP1A1
| Substances | Interaction | Organism | Category |
Advanced Summary
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Lung, lymphocytes and placenta.
Gene Pathways:
Induction:
By 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).
Molecular Function:
- Monooxygenase Activity
- Iron Ion Binding
- Steroid Hydroxylase Activity
- Oxidoreductase Activity
- Oxidoreductase Activity, Acting On Diphenols And Related Substances As Donors
- Flavonoid 3'-Monooxygenase Activity
- Oxygen Binding
- Heme Binding
- Demethylase Activity
- Aromatase Activity
- Vitamin D 24-Hydroxylase Activity
- Estrogen 16-Alpha-Hydroxylase Activity
Biological Processes:
- Response To Hypoxia
- Lipid Hydroxylation
- Porphyrin-Containing Compound Metabolic Process
- Aging
- Steroid Metabolic Process
- Cell Proliferation
- Amine Metabolic Process
- Response To Wounding
- Response To Virus
- Response To Nematode
- Response To Herbicide
- Ethylene Metabolic Process
- Embryo Development Ending In Birth Or Egg Hatching
- Coumarin Metabolic Process
- Flavonoid Metabolic Process
- Response To Iron(Iii) Ion
- Insecticide Metabolic Process
- Drug Metabolic Process
- Dibenzo-P-Dioxin Catabolic Process
- Epoxygenase P450 Pathway
- Response To Food
- Response To Lipopolysaccharide
- Response To Vitamin A
- Response To Immobilization Stress
- Vitamin D Metabolic Process
- 9-Cis-Retinoic Acid Biosynthetic Process
- Camera-Type Eye Development
- Response To Antibiotic
- Response To Arsenic-Containing Substance
- Digestive Tract Development
- Hydrogen Peroxide Biosynthetic Process
- Response To Hyperoxia
- Oxidation-Reduction Process
- Maternal Process Involved In Parturition
- Hepatocyte Differentiation
- Cellular Response To Organic Cyclic Compound
- Omega-Hydroxylase P450 Pathway
- Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
Drug Bank:
- Clobetasol Propionate
- Clomifene
- Dapagliflozin
- Dronabinol
- Erlotinib
- Isoprenaline
- Menadione
- Albendazole
- Amiodarone
- Amlodipine
- Amodiaquine
- Azelastine
- Benzyl Alcohol
- Bezafibrate
- Bortezomib
- Caffeine
- Chloroquine
- Chlorzoxazone
- Cholecalciferol
- Cinnarizine
- Clenbuterol
- Clonidine
- Clozapine
- Dacarbazine
- Dasatinib
- Debrisoquin
- Dexamethasone
- Dexmedetomidine
- Diclofenac
- Dicyclomine
- Estradiol
- Estrone
- Ethanol
- Fluorescein
- Flutamide
- Fluvastatin
- Fluvoxamine
- Granisetron
- Haloperidol
- Itraconazole
- Ketoconazole
- Lorcaserin
- Melatonin
- Methoxsalen
- Nifedipine
- Norfloxacin
- Omeprazole
- Nicotine
- Lansoprazole
- Ouabain
- Oxaliplatin
- Phenobarbital
- Prazosin
- Primaquine
- Progesterone
- Propofol
- Quinidine
- Quinine
- Rabeprazole
- Riluzole
- Romidepsin
- Sildenafil
- Streptozocin
- Sulindac
- Testosterone
- Thalidomide
- Theophylline
- Thiabendazole
- Ticlopidine
- Toremifene
- Vitamin A
- Warfarin
- Pyridoxine
- Acetaminophen
- Arsenic Trioxide
- Carvedilol
- Clofibrate
- Daunorubicin
- Flunarizine
- Gefitinib
- Mebendazole
- Nitroprusside
- Pentamidine
- Propranolol
- Riociguat
- Tamoxifen
- Tretinoin