Summary of CYCS
This gene encodes a protein that is part of the electron transport chain in mitochondria. It also starts the first step of programmed cell death (R).
The Function of CYCS
Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.
Protein names
Recommended name:
Cytochrome c- RS1861525 (CYCS) ??
- RS39453 (CYCS) ??
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Top Gene-Substance Interactions
CYCS Interacts with These Diseases
| Disease | Score |
Substances That Increase CYCS
| Substances | Interaction | Organism | Category |
Substances That Decrease CYCS
| Substances | Interaction | Organism | Category |
Advanced Summary
From NCBI Gene: Thrombocytopenia 4From UniProt: Thrombocytopenia 4 (THC4): Thrombocytopenia is defined by a decrease in the number of platelets in circulating blood, resulting in the potential for increased bleeding and decreased ability for clotting. [MIM:612004]
From NCBI Gene: This gene encodes a small heme protein that functions as a central component of the electron transport chain in mitochondria. The encoded protein associates with the inner membrane of the mitochondrion where it accepts electrons from cytochrome b and transfers them to the cytochrome oxidase complex. This protein is also involved in initiation of apoptosis. Mutations in this gene are associated with autosomal dominant nonsyndromic thrombocytopenia. Numerous processed pseudogenes of this gene are found throughout the human genome.[provided by RefSeq, Jul 2010] From UniProt: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.
Conditions with Increased Gene Activity
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Conditions with Decreased Gene Activity
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
- Metabolism
- Pathways in cancer
- Cellular responses to stress
- Tuberculosis
- Apoptosis
- Colorectal cancer
- Amyotrophic lateral sclerosis (ALS)
- Alzheimer's disease
- Apoptosis
- p53 signaling pathway
- Small cell lung cancer
- Toxoplasmosis
- Huntington's disease
- Viral myocarditis
- Organelle biogenesis and maintenance
- Parkinson's disease
Molecular Function:
- Heme Binding
- Electron Transporter, Transferring Electrons From Coqh2-Cytochrome C Reductase Complex And Cytochrome C Oxidase Complex Activity
- Metal Ion Binding
Biological Processes:
- Response To Reactive Oxygen Species
- Mitochondrial Electron Transport, Ubiquinol To Cytochrome C
- Mitochondrial Electron Transport, Cytochrome C To Oxygen
- Protein Dephosphorylation
- Mitochondrion Organization
- Activation Of Cysteine-Type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C
- Cellular Respiration
- Intrinsic Apoptotic Signaling Pathway