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CYCS (Cytochrome c, somatic)

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Summary of CYCS

This gene encodes a protein that is part of the electron transport chain in mitochondria. It also starts the first step of programmed cell death (R). 

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The Function of CYCS

Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.

Protein names

Recommended name:

Cytochrome c

CYCS SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS1861525 (CYCS) ??
  2. RS39453 (CYCS) ??

Top Gene-Substance Interactions

CYCS Interacts with These Diseases

Disease Score

Substances That Increase CYCS

Substances Interaction Organism Category

Substances That Decrease CYCS

Substances Interaction Organism Category

Advanced Summary

     From NCBI Gene: Thrombocytopenia 4From UniProt: Thrombocytopenia 4 (THC4): Thrombocytopenia is defined by a decrease in the number of platelets in circulating blood, resulting in the potential for increased bleeding and decreased ability for clotting. [MIM:612004]

     From NCBI Gene: This gene encodes a small heme protein that functions as a central component of the electron transport chain in mitochondria. The encoded protein associates with the inner membrane of the mitochondrion where it accepts electrons from cytochrome b and transfers them to the cytochrome oxidase complex. This protein is also involved in initiation of apoptosis. Mutations in this gene are associated with autosomal dominant nonsyndromic thrombocytopenia. Numerous processed pseudogenes of this gene are found throughout the human genome.[provided by RefSeq, Jul 2010] From UniProt: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • GR
  • GR-alpha
  • GR-beta

Gene Pathways:

  • Metabolism
  • Pathways in cancer
  • Cellular responses to stress
  • Tuberculosis
  • Apoptosis
  • Colorectal cancer
  • Amyotrophic lateral sclerosis (ALS)
  • Alzheimer's disease
  • Apoptosis
  • p53 signaling pathway
  • Small cell lung cancer
  • Toxoplasmosis
  • Huntington's disease
  • Viral myocarditis
  • Organelle biogenesis and maintenance
  • Parkinson's disease

Molecular Function:

  • Electron Transporter, Transferring Electrons From Coqh2-Cytochrome C Reductase Complex And Cytochrome C Oxidase Complex Activity
  • Heme Binding
  • Metal Ion Binding

Biological Processes:

  • Activation Of Cysteine-Type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C
  • Cellular Respiration
  • Intrinsic Apoptotic Signaling Pathway
  • Mitochondrial Electron Transport, Cytochrome C To Oxygen
  • Mitochondrial Electron Transport, Ubiquinol To Cytochrome C
  • Mitochondrion Organization
  • Protein Dephosphorylation
  • Response To Reactive Oxygen Species

Drug Bank:

  • Minocycline
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| cyc| CYCSA| cyct| cytc| cytochrome c| Cytochrome C, expressed in somatic tissues| cytochrome c-like protein| cytochrome c, testis| cytochrome c, testis-specific| EGK_13845| hcs| somatic cytochrome c| THC4| cycs

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