Summary of CXCR5
This gene encodes a multi-pass membrane protein and is involved in B cell migration (R).
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0 users want it decreased
The Function of CXCR5
Cytokine receptor that binds to B-lymphocyte chemoattractant (BLC). Involved in B-cell migration into B-cell follicles of spleen and Peyer patches but not into those of mesenteric or peripheral lymph nodes. May have a regulatory function in Burkitt lymphoma (BL) lymphomagenesis and/or B-cell differentiation.
Protein names
Recommended name:
C-X-C chemokine receptor type 5Short name:
CXC-R5Alternative name(s):
CXCR-5Burkitt lymphoma receptor 1
Monocyte-derived receptor 15
MDR-15
CD antigen CD185
- RS10790268 (CXCR5) ??
- RS4938573 (CXCR5) ??
- RS630923 (CXCR5) ??
- RS638893 (CXCR5) ??
- RS6421571 (CXCR5) ??
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Top Gene-Substance Interactions
Substances That Increase CXCR5
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Substances That Decrease CXCR5
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expression in mature B-cells and Burkitt lymphoma cells.
Gene Pathways:
Molecular Function:
Biological Processes:
- B Cell Activation
- G-Protein Coupled Receptor Signaling Pathway
- Immune Response
- Leukocyte Chemotaxis
- Lymph Node Development
- Movement Of Cell Or Subcellular Component
- Positive Regulation Of Cytokinesis
- Chemotaxis