CXCR1 (C-X-C motif chemokine receptor 1) is the gene that encodes for a protein that is a receptor for interleukin 8. It is important for the development of spinal cords in humans (R). 

Blocking this protein can help prevent breast cancer in vitro (R). 

Bad Effects

• rs2234671 is associated with Hepatitis B infection (R). 
• High levels of IL8 is associated with poor memory and motor function in elderly patients (R).
• It is associated with allergic diseases and atopy (R).
• It is a key regulator in tumor cell proliferation, metastasis, and angiogenesis (R). 

     From NCBI Gene: Human immunodeficiency virus type 1, susceptibility to

     From NCBI Gene: The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. Knockout studies in mice suggested that this protein inhibits embryonic oligodendrocyte precursor migration in developing spinal cord. This gene, IL8RB, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. [provided by RefSeq, Jul 2008] From UniProt: Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity.