Summary of CXCL9
Functions as an antimicrobial gene (kills pathogens). It is believed to be involved in T cell trafficking. [R]
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The Function of CXCL9
Cytokine that affects the growth, movement, or activation state of cells that participate in immune and inflammatory response. Chemotactic for activated T-cells. Binds to CXCR3.
Protein names
Recommended name:
C-X-C motif chemokine 9Short name:
MIGAlternative name(s):
Gamma-interferon-induced monokineMonokine induced by interferon-gamma
HuMIG
Small-inducible cytokine B9
- RS10336 (CXCL9) ??
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Top Gene-Substance Interactions
CXCL9 Interacts with These Diseases
| Disease | Score |
Substances That Increase CXCL9
| Substances | Interaction | Organism | Category |
Substances That Decrease CXCL9
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Gene Pathways:
Induction:
By IFNG/IFN-gamma. The induction is enhanced by TNF in dermal fibroblasts and vein endothelial cells.
Molecular Function:
Biological Processes:
- Positive Regulation Of Leukocyte Chemotaxis
- Chemotaxis
- Defense Response
- Inflammatory Response
- Immune Response
- Cellular Defense Response
- Signal Transduction
- G-Protein Coupled Receptor Signaling Pathway
- Cell-Cell Signaling
- Positive Regulation Of Camp Metabolic Process
- Response To Lipopolysaccharide
- Regulation Of Cell Proliferation
- Positive Regulation Of Camp-Mediated Signaling
- Positive Regulation Of Myoblast Differentiation
- Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
- Defense Response To Virus
- Chemokine-Mediated Signaling Pathway
- Positive Regulation Of Myoblast Fusion