Summary of CXCL8
C-X-C motif chemokine ligand 8 (CXCL8) encodes a protein that is part of the chemokine family. This protein plays an important role as a mediator in the inflammatory response.
Problems associated with CXCL8 include:
The Function of CXCL8
IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively.
Protein names
Recommended name:
Interleukin-8Short name:
NAFAlternative name(s):
IL-8C-X-C motif chemokine 8
Chemokine (C-X-C motif
Emoctakin
Granulocyte chemotactic protein 1
GCP-1
Monocyte-derived neutrophil chemotactic factor
MDNCF
Monocyte-derived neutrophil-activating peptide
MONAP
Neutrophil-activating protein 1
NAP-1
Protein 3-10C
T-cell chemotactic factor
GCP/IL-8 protein IV
IL8/NAP1 form I
(Ala-IL-8
GCP/IL-8 protein II
IL-8(1-77
IL8/NAP1 form II
MDNCF-b
5-77
6-77
(Ser-IL-8
GCP/IL-8 protein I
IL8/NAP1 form III
Lymphocyte-derived neutrophil-activating factor
LYNAP
MDNCF-c
Neutrophil-activating factor
7-77
GCP/IL-8 protein V
IL8/NAP1 form IV
8-77
GCP/IL-8 protein VI
IL8/NAP1 form V
9-77
GCP/IL-8 protein III
IL8/NAP1 form VI
- RS2227532 (CXCL8) ??
- RS4073 (CXCL8) ??
To see your genotype, you should be logged in and have a file with your genotype uploaded.
Top Gene-Substance Interactions
CXCL8 Interacts with These Diseases
Disease | Score |
Fixes
Methods to mitigate CXCL8 effects:
- Increased intake of Quercetin (found in many fruits and vegetables) [R].
Substances That Increase CXCL8
Substances | Interaction | Organism | Category |
Substances That Decrease CXCL8
Substances | Interaction | Organism | Category |
Advanced Summary
C-X-C motif chemokine ligand 8 (CXCL8) encodes a protein that is part of the chemokine family. This protein plays an important role as a mediator in the inflammatory response.
Problems associated with CXCL8 include:
Conditions with Increased Gene Activity
Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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