• Navigation
  • Register My DNA Kit
  • Features
  • Pricing
  • FAQ
  • About
  • Labs
  • Login
  • Get started
  1. Home
  2. Genes
  3. CXCL8

CXCL8 (C-X-C motif chemokine ligand 8)

Loading...

Summary of CXCL8

C-X-C motif chemokine ligand 8 (CXCL8) encodes a protein that is part of the chemokine family. This protein plays an important role  as a mediator in the inflammatory response. 

Problems associated with CXCL8 include:

  • bronchiolitis (a lung disease) (R)
  • acne (R)
  • cystic fibrosis (R)
  • schizophrenia (R)
  • colon cancer (R)
0 users want this gene increased, 0 users want it decreased

The Function of CXCL8

IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively.

Protein names

Recommended name:

Interleukin-8

Short name:

NAF

Alternative name(s):

IL-8
C-X-C motif chemokine 8
Chemokine (C-X-C motif
Emoctakin
Granulocyte chemotactic protein 1
GCP-1
Monocyte-derived neutrophil chemotactic factor
MDNCF
Monocyte-derived neutrophil-activating peptide
MONAP
Neutrophil-activating protein 1
NAP-1
Protein 3-10C
T-cell chemotactic factor
GCP/IL-8 protein IV
IL8/NAP1 form I
(Ala-IL-8
GCP/IL-8 protein II
IL-8(1-77
IL8/NAP1 form II
MDNCF-b
5-77
6-77
(Ser-IL-8
GCP/IL-8 protein I
IL8/NAP1 form III
Lymphocyte-derived neutrophil-activating factor
LYNAP
MDNCF-c
Neutrophil-activating factor
7-77
GCP/IL-8 protein V
IL8/NAP1 form IV
8-77
GCP/IL-8 protein VI
IL8/NAP1 form V
9-77
GCP/IL-8 protein III
IL8/NAP1 form VI

CXCL8 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS2227532 (CXCL8) ??
  2. RS4073 (CXCL8) ??

Top Gene-Substance Interactions

CXCL8 Interacts with These Diseases

Disease Score

Fixes

Methods to mitigate CXCL8 effects:

  • Increased intake of Quercetin (found in many fruits and vegetables) [R].

Substances That Increase CXCL8

Substances Interaction Organism Category

Substances That Decrease CXCL8

Substances Interaction Organism Category

Advanced Summary

C-X-C motif chemokine ligand 8 (CXCL8) encodes a protein that is part of the chemokine family. This protein plays an important role  as a mediator in the inflammatory response. 

Problems associated with CXCL8 include:

  • bronchiolitis (a lung disease) (R)
  • acne (R)
  • cystic fibrosis (R)
  • schizophrenia (R)
  • colon cancer (R)

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Policies

  • Terms of Service
  • Platform Consent
  • Privacy Policy
  • Disclaimer

About

  • Customer Support
  • Our Team
  • Affiliate Program

Navigation

  • Homepage
  • DNA Wellness Reports
  • Personalized Genetics Blog
  • Register your DNA Test Kit
  • Login
  • Careers
GET STARTED
  • SelfDecode is a personalized health report service, which enables users to obtain detailed information and reports based on their genome. SelfDecode does not treat, diagnose or cure any conditions, but is for informational and educational purposes alone.
SelfDecode © 2021 All Rights Reserved