The Function of CXCL6
Chemotactic for neutrophil granulocytes. Signals through binding and activation of its receptors (CXCR1 and CXCR2). In addition to its chemotactic and angiogenic properties, it has strong antibacterial activity against Gram-positive and Gram-negative bacteria (90-fold-higher when compared to CXCL5 and CXCL7).
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Protein names
Recommended name:
C-X-C motif chemokine 6Short name:
CKA-3Alternative name(s):
Chemokine alpha 3Granulocyte chemotactic protein 2
GCP-2
Small-inducible cytokine B6
Top Gene-Substance Interactions
CXCL6 Interacts with These Diseases
| Disease | Score |
Substances That Increase CXCL6
| Substances | Interaction | Organism | Category |
Substances That Decrease CXCL6
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
Biological Processes:
- Neutrophil Mediated Immunity
- Positive Regulation Of Leukocyte Chemotaxis
- Chemotaxis
- Inflammatory Response
- Immune Response
- Signal Transduction
- G-Protein Coupled Receptor Signaling Pathway
- Cell-Cell Signaling
- Response To Lipopolysaccharide
- Regulation Of Cell Proliferation
- Defense Response To Bacterium
- Chemokine-Mediated Signaling Pathway