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  3. CXCL5

CXCL5 (C-X-C motif chemokine ligand 5)

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Summary of CXCL5

This gene encodes a protein that is a chemokine. It promotes the formation of new blood vessels and helps remodel connective tissues. It might play a role in cancer cell proliferation, migration, and invasion (R). 

0 users want this gene increased, 0 users want it decreased

The Function of CXCL5

Involved in neutrophil activation. In vitro, ENA-78(8-78) and ENA-78(9-78) show a threefold higher chemotactic activity for neutrophil granulocytes.

Protein names

Recommended name:

C-X-C motif chemokine 5

Short name:

8-78

Alternative name(s):

ENA-78(1-78
Epithelial-derived neutrophil-activating protein 78
Neutrophil-activating peptide ENA-78
Small-inducible cytokine B5
9-78

CXCL5 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS2457996 (CXCL5) ??
  2. RS2472649 (CXCL5) ??
  3. RS425535 (CXCL5) ??

Top Gene-Substance Interactions

CXCL5 Interacts with These Diseases

Disease Score

Substances That Increase CXCL5

Substances Interaction Organism Category

Substances That Decrease CXCL5

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • PPAR-gamma1
  • PPAR-gamma2
  • IRF-1
  • STAT1
  • STAT1beta
  • STAT1alpha

Gene Pathways:

  • Signal Transduction
  • Cytokine-cytokine receptor interaction
  • Chemokine signaling pathway
  • Rheumatoid arthritis

Molecular Function:

  • Chemokine Activity
  • Cxcr Chemokine Receptor Binding

Biological Processes:

  • Cell-Cell Signaling
  • Chemokine-Mediated Signaling Pathway
  • Chemotaxis
  • G-Protein Coupled Receptor Signaling Pathway
  • Immune Response
  • Inflammatory Response
  • Neutrophil Mediated Immunity
  • Positive Regulation Of Cell Proliferation
  • Positive Regulation Of Leukocyte Chemotaxis
  • Response To Lipopolysaccharide
  • Signal Transduction
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| AMCF-II| chemokine (C-X-C motif) ligand 5| chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)| CXCL6| C-X-C motif chemokine 5| C-X-C motif chemokine 6| cytokine LIX| ENA-78| epithelial-derived neutrophil-activating protein 78| GCP2| GCP-2| granulocyte chemotactic protein 2| granulocyte chemotactic protein-2| inducible cytokine subfamily B (Cys-X-Cys), member 6| LIX| neutrophil-activating peptide ENA-78| neutrophil-activating protein 78| PANDA_007790| SCYB5| SCYB6| small-inducible cytokine B5| small-inducible cytokine B6| small inducible cytokine B subfamily, member 5| small inducible cytokine subfamily B (Cys-X-Cys), member 5 (epithelial-derived neutrophil-activating peptide 78)| small inducible cytokine subfamily B, member 15| cxcl5

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