The Function of CXCL3
Ligand for CXCR2 (By similarity). Has chemotactic activity for neutrophils. May play a role in inflammation and exert its effects on endothelial cells in an autocrine fashion. In vitro, the processed form GRO-gamma(5-73) shows a fivefold higher chemotactic activity for neutrophilic granulocytes.
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Protein names
Recommended name:
C-X-C motif chemokine 3Short name:
5-73Alternative name(s):
GRO-gamma(1-73Growth-regulated protein gamma
GRO-gamma
Macrophage inflammatory protein 2-beta
MIP2-beta
Top Gene-Substance Interactions
CXCL3 Interacts with These Diseases
| Disease | Score |
Substances That Increase CXCL3
| Substances | Interaction | Organism | Category |
Substances That Decrease CXCL3
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
Biological Processes:
- Chemokine-Mediated Signaling Pathway
- G-Protein Coupled Receptor Signaling Pathway
- Immune Response
- Inflammatory Response
- Neutrophil Chemotaxis
- Positive Regulation Of Neutrophil Chemotaxis
- Regulation Of Cell Proliferation
- Response To Lipopolysaccharide