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  3. CXCL3

CXCL3 (C-X-C motif chemokine ligand 3)

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The Function of CXCL3

Ligand for CXCR2 (By similarity). Has chemotactic activity for neutrophils. May play a role in inflammation and exert its effects on endothelial cells in an autocrine fashion. In vitro, the processed form GRO-gamma(5-73) shows a fivefold higher chemotactic activity for neutrophilic granulocytes.

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Protein names

Recommended name:

C-X-C motif chemokine 3

Short name:

5-73

Alternative name(s):

GRO-gamma(1-73
Growth-regulated protein gamma
GRO-gamma
Macrophage inflammatory protein 2-beta
MIP2-beta

Top Gene-Substance Interactions

CXCL3 Interacts with These Diseases

Disease Score

Substances That Increase CXCL3

Substances Interaction Organism Category

Substances That Decrease CXCL3

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • Evi-1
  • MEF-2A
  • GATA-1
  • GATA-2
  • GATA-3
  • AP-2rep
  • LCR-F1

Gene Pathways:

  • Signal Transduction
  • Cytokine-cytokine receptor interaction
  • Chemokine signaling pathway

Molecular Function:

  • Chemokine Activity
  • Cxcr Chemokine Receptor Binding

Biological Processes:

  • Chemokine-Mediated Signaling Pathway
  • G-Protein Coupled Receptor Signaling Pathway
  • Immune Response
  • Inflammatory Response
  • Neutrophil Chemotaxis
  • Positive Regulation Of Neutrophil Chemotaxis
  • Regulation Of Cell Proliferation
  • Response To Lipopolysaccharide
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

GRO3| GRO3 oncogene| GRO-gamma| chemokine CXCL3/GRO-GAMMA| chemokine (C-X-C motif) ligand 3| Cinc2| Cinc-2| CINC-2b| CXC chemokine CXCL3L| CXCL3L| C-X-C motif chemokine 3| cytokine-induced neutrophil chemoattractant 2| Dcip1| dendritic cell inflammatory protein 1| epithelial cell inflammatory protein| GROg| GRO-gamma(1-73)| growth-regulated protein gamma| macrophage inflammatory protein 2-alpha/beta| macrophage inflammatory protein 2-beta| melanoma growth stimulatory activity gamma| MGSA gamma| MIP2-alpha/beta| MIP-2b| MIP2B| MIP2-beta| SCYB3| tumor-induced factor| cxcl3

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