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  3. CXCL14

CXCL14 (C-X-C motif chemokine ligand 14)

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The Function of CXCL14

Potent chemoattractant for neutrophils, and weaker for dendritic cells. Not chemotactic for T-cells, B-cells, monocytes, natural killer cells or granulocytes. Does not inhibit proliferation of myeloid progenitors in colony formation assays.

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Protein names

Recommended name:

C-X-C motif chemokine 14

Short name:

MIP-2G

Alternative name(s):

Chemokine BRAK
Small-inducible cytokine B14

CXCL14 SNPs

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  1. RS10045413 (CXCL14) ??

Top Gene-Substance Interactions

CXCL14 Interacts with These Diseases

Disease Score

Substances That Increase CXCL14

Substances Interaction Organism Category

Substances That Decrease CXCL14

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • NF-kappaB1

Tissue specificity:

Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Highly expressed in normal tissue without inflammatory stimuli and infrequently expressed in cancer cell lines. Weakly expressed in monocyte-derived dendritic cells. Not detected in lung or unstimulated peripheral blood lymphocytes.

Gene Pathways:

  • Cytokine-cytokine receptor interaction
  • Chemokine signaling pathway

Induction:

Up-regulated in peripheral blood lymphocytes in response to bacterial lipopolysaccharides (LPS).

Caution:

It is uncertain whether Met-1 or Met-13 is the initiator.

Molecular Function:

  • Chemokine Activity

Biological Processes:

  • Cell-Cell Signaling
  • Chemotaxis
  • Immune Response
  • Inner Ear Development
  • Negative Regulation Of Myoblast Differentiation
  • Positive Regulation Of Natural Killer Cell Chemotaxis
  • Signal Transduction
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_14585| AS27_12065| AS28_08187| B-cell and monocyte-activating chemokine| bmac| bolekine| brak| breast and kidney| CB1_000686003| chemokine BRAK| chemokine CXCL14| chemokine (C-X-C motif) ligand 14| chemokine ligand 14| CXC chemokine in breast and kidney| C-X-C motif chemokine 14| D623_10032619| EH28_12514| fb67g04| GekBS033P| GW7_09530| H920_19390| I79_010626| JSC| jun-suppressed chemokine| KEC| kidney-expressed chemokine CXC| ks1| M91_21037| M959_09652| MDA_GLEAN10012359| member a| MIP-2g| MIP2G| MIP2gamma| MIP-2 gamma| musculus CXC chemokine MIP-2gamma| N300_11045| N301_09275| N302_12387| N303_03168| N305_11409| N306_11916| N307_10081| N308_05240| N309_01486| N310_13591| N311_04807| N312_09811| N320_08901| N321_14290| N322_06021| N324_03064| N325_04730| N326_08306| N327_12892| N328_03457| N330_10254| N331_02763| N332_06454| N333_04300| N335_13376| N336_06170| N339_06790| N340_11258| N341_00649| njac| PAL_GLEAN10016847| PANDA_000767| Scyb14| scyba| small inducible cytokine B14| small-inducible cytokine B14| small inducible cytokine subfamily B (Cys-X-Cys), member 14| small inducible cytokine subfamily B (Cys-X-Cys), member 14 (BRAK)| small inducible cytokine subfamily b (Cys-X-Cys), member a| TREES_T100018915| tumor-suppressing chemokine| Y1Q_014634| Z169_02229| cxcl14

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