The Function of CXCL14
Potent chemoattractant for neutrophils, and weaker for dendritic cells. Not chemotactic for T-cells, B-cells, monocytes, natural killer cells or granulocytes. Does not inhibit proliferation of myeloid progenitors in colony formation assays.
Protein names
Recommended name:
C-X-C motif chemokine 14Short name:
MIP-2GAlternative name(s):
Chemokine BRAKSmall-inducible cytokine B14
- RS10045413 (CXCL14) ??
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Top Gene-Substance Interactions
CXCL14 Interacts with These Diseases
| Disease | Score |
Substances That Increase CXCL14
| Substances | Interaction | Organism | Category |
Substances That Decrease CXCL14
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Highly expressed in normal tissue without inflammatory stimuli and infrequently expressed in cancer cell lines. Weakly expressed in monocyte-derived dendritic cells. Not detected in lung or unstimulated peripheral blood lymphocytes.
Induction:
Up-regulated in peripheral blood lymphocytes in response to bacterial lipopolysaccharides (LPS).
Caution:
It is uncertain whether Met-1 or Met-13 is the initiator.
Molecular Function:
Biological Processes:
- Chemotaxis
- Immune Response
- Signal Transduction
- Cell-Cell Signaling
- Negative Regulation Of Myoblast Differentiation
- Inner Ear Development
- Positive Regulation Of Natural Killer Cell Chemotaxis