• Navigation
  • Register My DNA Kit
  • Features
  • Pricing
  • FAQ
  • About
  • Labs
  • Login
  • Get started
  1. Home
  2. Genes
  3. CXCL12

CXCL12 (C-X-C motif chemokine ligand 12)

Loading...

Summary of CXCL12

This gene encodes a protein that plays a role in formation of embryos, immune system response, tissue homeostasis, and tumor growth (R). 

0 users want this gene increased, 0 users want it decreased

The Function of CXCL12

Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells. Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation.

Protein names

Recommended name:

Stromal cell-derived factor 1

Short name:

IRH

Alternative name(s):

SDF-1
hSDF-1
C-X-C motif chemokine 12
Intercrine reduced in hepatomas
hIRH
Pre-B cell growth-stimulating factor
PBSF
3-72
3-67

CXCL12 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS1801157 (CXCL12) ??
  2. RS2297630 (CXCL12) ??
  3. RS266093 (CXCL12) ??
  4. RS266095 (CXCL12) ??

Top Gene-Substance Interactions

CXCL12 Interacts with These Diseases

Disease Score

Substances That Increase CXCL12

Substances Interaction Organism Category

Substances That Decrease CXCL12

Substances Interaction Organism Category

Advanced Summary

     From NCBI Gene: Human immunodeficiency virus type 1, susceptibility to

     From NCBI Gene: This antimicrobial gene encodes a stromal cell-derived alpha chemokine member of the intercrine family. The encoded protein functions as the ligand for the G-protein coupled receptor, chemokine (C-X-C motif) receptor 4, and plays a role in many diverse cellular functions, including embryogenesis, immune surveillance, inflammation response, tissue homeostasis, and tumor growth and metastasis. Mutations in this gene are associated with resistance to human immunodeficiency virus type 1 infections. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014] From UniProt: Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells. Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • p53
  • NF-1

Tissue specificity:

Isoform Alpha and isoform Beta are ubiquitously expressed, with highest levels detected in liver, pancreas and spleen. Isoform Gamma is mainly expressed in heart, with weak expression detected in several other tissues. Isoform Delta, isoform Epsilon and isoform Theta have highest expression levels in pancreas, with lower levels detected in heart, kidney, liver and spleen.

Gene Pathways:

  • Signal Transduction
  • Cytokine-cytokine receptor interaction
  • Leukocyte transendothelial migration
  • Axon guidance
  • Chemokine signaling pathway
  • Intestinal immune network for IgA production
  • Rheumatoid arthritis

Developmental stage:

Isoform Alpha is ubiquitously expressed in fetal tissues. Isoform Beta and isoform Delta have more limited expression patterns, with highest levels detected in fetal spleen and fetal liver, respectively. Isoform Gamma and isoform Theta are weakly detected in fetal kidney.

Molecular Function:

  • Chemoattractant Activity
  • Chemokine Activity
  • Chemokine Receptor Binding
  • Cxcr Chemokine Receptor Binding
  • Receptor Binding

Biological Processes:

  • Adult Locomotory Behavior
  • Animal Organ Regeneration
  • Axon Guidance
  • Blood Circulation
  • Cell Adhesion
  • Cell Chemotaxis
  • Cellular Calcium Ion Homeostasis
  • Chemokine-Mediated Signaling Pathway
  • Chemotaxis
  • Defense Response
  • G-Protein Coupled Receptor Signaling Pathway
  • Immune Response
  • Induction Of Positive Chemotaxis
  • Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Dna Damage
  • Negative Regulation Of Leukocyte Apoptotic Process
  • Negative Regulation Of Leukocyte Tethering Or Rolling
  • Neuron Migration
  • Positive Regulation Of Axon Extension Involved In Axon Guidance
  • Positive Regulation Of Calcium Ion Import
  • Positive Regulation Of Cell Adhesion
  • Positive Regulation Of Dopamine Secretion
  • Positive Regulation Of Endothelial Cell Proliferation
  • Positive Regulation Of Monocyte Chemotaxis
  • Positive Regulation Of T Cell Migration
  • Regulation Of Actin Polymerization Or Depolymerization
  • Response To Heat
  • Response To Hypoxia
  • Response To Mechanical Stimulus
  • Response To Peptide Hormone
  • Response To Radiation
  • Response To Virus
  • Signal Transduction
  • Telencephalon Cell Migration

Drug Bank:

  • Tinzaparin
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| 12-O-tetradecanoylphorbol 13-acetate repressed protein 1| A306_03967| Anapl_10913| AS27_02594| AS28_04471| CB1_000354002| chemokine CXCL12| chemokine CXCL12/SDF-1ALPHA| chemokine (C-X-C motif) ligand 12| chemokine C-X-C motif ligand 12| chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1)| chemokine ligand 12b| CXC chemokine| C-X-C chemokine ligand 12| CXCL12 chemokine| C-X-C motif chemokine 12| D623_10002859| GW7_14914| intercrine reduced in hepatomas| IRH| M959_03228| MDA_GLEAN10005597| N300_07514| N301_10656| N302_13478| N303_09199| N305_11450| N306_13853| N307_06132| N308_09049| N309_10023| N310_05563| N311_03780| N312_08532| N320_12667| N321_11053| N322_03882| N324_12879| N326_12324| N327_08539| N328_11366| N329_11670| N330_10017| N331_07748| N332_07843| N333_06516| N334_01518| N335_08377| N336_04054| N340_11115| N341_07395| PAL_GLEAN10003906| PANDA_016671| Pbsf| pre-B cell growth-stimulating factor| pre-B-cell growth-stimulating factor| putative stromal cell derived factor 1| Scyb12| sdf-1| SDF1| sdf1a| sdf-1a| sdf1b| sdf-1b| SDF-1beta| SDF-1 gamma| spleen stromal cell-derived factor-1| stromal cell derived factor 1| stromal cell-derived factor 1| stromal cell-derived factor-1| stromal cell-derived factor 1a| stromal cell-derived factor-1 beta| stromal cell-derived factor-1 gamma| stromal cell-derived factor 1 isoform alpha| stromal cell-derived factor 1 isoform beta| stromal cell-derived factor 1 isoform delta| stromal cell-derived factor 1 isoform gamma| stromal cell derived factor 1-like| stromal cell-derived factor 1-like protein| stromal-derived factor 1| thymic lymphoma cell-stimulating factor| Tlsf| tlsf-a| tlsf-b| tpar1| TREES_T100006442| UY3_16348| xSDF-1| xSDF-1alpha| Y1Q_000814| Y956_01529| Z169_12804| cxcl12

Policies

  • Terms of Service
  • Platform Consent
  • Privacy Policy
  • Disclaimer

About

  • Customer Support
  • Our Team
  • Affiliate Program

Navigation

  • Homepage
  • DNA Wellness Reports
  • Personalized Genetics Blog
  • Register your DNA Test Kit
  • Login
  • Careers
GET STARTED
  • SelfDecode is a personalized health report service, which enables users to obtain detailed information and reports based on their genome. SelfDecode does not treat, diagnose or cure any conditions, but is for informational and educational purposes alone.
SelfDecode © 2021 All Rights Reserved