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CTSS (Cathepsin S)

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Summary of CTSS

ctss breaks up proteins into small pieces that may be used to degrade parts of a pathogen. This includes disease causing bacteria, virus, or protozoan into small peptides. A Major Histocompatibility Complex (MHC) class II recognizes these peptides and signals for the immune response to take place. [R]

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The Function of CTSS

Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N.

Protein names

Recommended name:

Cathepsin S

CTSS SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS11576175 (CTSS) ??
  2. RS2230061 (CTSS) ??

Top Gene-Substance Interactions

CTSS Interacts with These Diseases

Disease Score

Substances That Increase CTSS

Substances Interaction Organism Category

Substances That Decrease CTSS

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • Egr-1
  • IRF-1
  • STAT1
  • STAT1beta
  • STAT1alpha

Gene Pathways:

  • Immune System
  • Tuberculosis
  • Extracellular matrix organization
  • Antigen processing and presentation
  • Lysosome
  • Phagosome

Molecular Function:

  • Collagen Binding
  • Cysteine-Type Endopeptidase Activity
  • Fibronectin Binding
  • Laminin Binding
  • Proteoglycan Binding
  • Serine-Type Endopeptidase Activity

Biological Processes:

  • Adaptive Immune Response
  • Antigen Processing And Presentation
  • Antigen Processing And Presentation Of Exogenous Peptide Antigen Via Mhc Class Ii
  • Antigen Processing And Presentation Of Peptide Antigen
  • Basement Membrane Disassembly
  • Cellular Response To Thyroid Hormone Stimulus
  • Collagen Catabolic Process
  • Extracellular Matrix Disassembly
  • Immune Response
  • Positive Regulation Of Cation Channel Activity
  • Protein Processing
  • Proteolysis
  • Proteolysis Involved In Cellular Protein Catabolic Process
  • Response To Acidic Ph
  • Toll-Like Receptor Signaling Pathway
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_12999| cathepsin S, gene 1| cathepsin S isoform 1 preproprotein| cathepsin S-like protein| cathepsin S preproprotein| cathepsinS related protein| Cats| Cat S| ctss.1| ctss-a| ctss-b| EGK_01236| M91_14453| M959_14878| MDA_GLEAN10009664| N310_04795| N312_09455| N321_07575| N330_06072| N331_05746| N333_07232| N334_07040| N339_00088| N340_06723| PAL_GLEAN10017545| PANDA_008012| TREES_T100021286| ctss

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