Summary of CTSS
ctss breaks up proteins into small pieces that may be used to degrade parts of a pathogen. This includes disease causing bacteria, virus, or protozoan into small peptides. A Major Histocompatibility Complex (MHC) class II recognizes these peptides and signals for the immune response to take place. [R]
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The Function of CTSS
Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N.
Protein names
Recommended name:
Cathepsin S- RS11576175 (CTSS) ??
- RS2230061 (CTSS) ??
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Top Gene-Substance Interactions
CTSS Interacts with These Diseases
| Disease | Score |
Substances That Increase CTSS
| Substances | Interaction | Organism | Category |
Substances That Decrease CTSS
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
- Fibronectin Binding
- Cysteine-Type Endopeptidase Activity
- Serine-Type Endopeptidase Activity
- Collagen Binding
- Laminin Binding
- Proteoglycan Binding
Biological Processes:
- Toll-Like Receptor Signaling Pathway
- Adaptive Immune Response
- Proteolysis
- Immune Response
- Response To Acidic Ph
- Protein Processing
- Antigen Processing And Presentation
- Antigen Processing And Presentation Of Exogenous Peptide Antigen Via Mhc Class Ii
- Extracellular Matrix Disassembly
- Collagen Catabolic Process
- Basement Membrane Disassembly
- Antigen Processing And Presentation Of Peptide Antigen
- Proteolysis Involved In Cellular Protein Catabolic Process
- Cellular Response To Thyroid Hormone Stimulus
- Positive Regulation Of Cation Channel Activity