Summary of CTLA4
This gene encodes a protein which transmits an inhibitory signal to T cells. Mutations in this gene have been associated autoimmune diseases including: diabetes, Graves disease, thryoid problems, celiac disease, and lupus (R).
In general, it's better to have more CTLA4 except in cases of cancer.
The Function of CTLA4
Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.
Protein names
Recommended name:
Cytotoxic T-lymphocyte protein 4Short name:
CTLA-4Alternative name(s):
Cytotoxic T-lymphocyte-associated antigen 4CD antigen CD152
- RS1024161 (CTLA4) ??
- RS11571302 (CTLA4) ??
- RS11571316 (CTLA4) ??
- RS11571317 (CTLA4) ??
- RS16840252 (CTLA4) ??
- RS231725 (CTLA4) ??
- RS231775 (CTLA4) ??
- RS231777 (CTLA4) ??
- RS231779 (CTLA4) ??
- RS3087243 (CTLA4) ??
- RS4553808 (CTLA4) ??
- RS5742909 (CTLA4) ??
- RS733618 (CTLA4) ??
To see your genotype, you should be logged in and have a file with your genotype uploaded.
Top Gene-Substance Interactions
CTLA4 Interacts with These Diseases
| Disease | Score |
Substances That Increase CTLA4
| Substances | Interaction | Organism | Category |
Substances That Decrease CTLA4
| Substances | Interaction | Organism | Category |
Advanced Summary
CTLA4 is a receptor that inhibits T-cell responses. CTLA4 is found on Tregs and activated T cells. It acts as an "off" switch when bound to CD80 or CD86 on the surface of antigen-presenting cells.
Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, multiple sclerosis, thyroid-associated orbitopathy, and other autoimmune diseases.
CTLA-4 has been shown to interact with:
- AP2M1
- CD80
- CD86
- SHP-2
- PPP2R5A
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Widely expressed with highest levels in lymphoid tissues. Detected in activated T-cells where expression levels are 30- to 50-fold less than CD28, the stimulatory coreceptor, on the cell surface following activation.
Gene Pathways:
Biological Processes:
- Adaptive Immune Response
- Immune Response
- Cellular Response To Dna Damage Stimulus
- Negative Regulation Of B Cell Proliferation
- T Cell Costimulation
- Negative Regulation Of T Cell Proliferation
- Positive Regulation Of Apoptotic Process
- Negative Regulation Of Regulatory T Cell Differentiation
- Negative Regulation Of Immune Response
- B Cell Receptor Signaling Pathway
Drug Bank:
- Ipilimumab