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  3. CTLA4

CTLA4 (Cytotoxic T-lymphocyte associated protein 4)

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Summary of CTLA4

This gene encodes a protein which transmits an inhibitory signal to T cells. Mutations in this gene have been associated autoimmune diseases including: diabetes, Graves disease, thryoid problems, celiac disease, and lupus (R). 

In general, it's better to have more CTLA4 except in cases of cancer.

0 users want this gene increased, 0 users want it decreased

The Function of CTLA4

Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.

Protein names

Recommended name:

Cytotoxic T-lymphocyte protein 4

Short name:

CTLA-4

Alternative name(s):

Cytotoxic T-lymphocyte-associated antigen 4
CD antigen CD152

CTLA4 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS1024161 (CTLA4) ??
  2. RS11571302 (CTLA4) ??
  3. RS11571316 (CTLA4) ??
  4. RS11571317 (CTLA4) ??
  5. RS16840252 (CTLA4) ??
  6. RS231725 (CTLA4) ??
  7. RS231775 (CTLA4) ??
  8. RS231777 (CTLA4) ??
  9. RS231779 (CTLA4) ??
  10. RS3087243 (CTLA4) ??
  11. RS4553808 (CTLA4) ??
  12. RS5742909 (CTLA4) ??
  13. RS733618 (CTLA4) ??

Top Gene-Substance Interactions

CTLA4 Interacts with These Diseases

Disease Score

Substances That Increase CTLA4

Substances Interaction Organism Category

Substances That Decrease CTLA4

Substances Interaction Organism Category

Advanced Summary

CTLA4 is a receptor that inhibits T-cell responses. CTLA4 is found on Tregs and activated T cells.  It acts as an "off" switch when bound to CD80 or CD86 on the surface of antigen-presenting cells.

Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, multiple sclerosis, thyroid-associated orbitopathy, and other autoimmune diseases. 

CTLA-4 has been shown to interact with:

  • AP2M1
  • CD80
  • CD86
  • SHP-2
  • PPP2R5A

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • AP-1
  • c-Jun
  • STAT5A
  • AML1a
  • STAT4
  • NF-AT2

Tissue specificity:

Widely expressed with highest levels in lymphoid tissues. Detected in activated T-cells where expression levels are 30- to 50-fold less than CD28, the stimulatory coreceptor, on the cell surface following activation.

Gene Pathways:

  • Immune System
  • Autoimmune thyroid disease
  • T cell receptor signaling pathway
  • Cell adhesion molecules (CAMs)
  • Rheumatoid arthritis

Biological Processes:

  • Adaptive Immune Response
  • B Cell Receptor Signaling Pathway
  • Cellular Response To Dna Damage Stimulus
  • Immune Response
  • Negative Regulation Of B Cell Proliferation
  • Negative Regulation Of Immune Response
  • Negative Regulation Of Regulatory T Cell Differentiation
  • Negative Regulation Of T Cell Proliferation
  • Positive Regulation Of Apoptotic Process
  • T Cell Costimulation

Drug Bank:

  • Ipilimumab
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| CD| A306_01994| ALPS5| Anapl_00646| AS27_10573| AS28_03286| CB1_002756018| Cd152| CD152 antigen| CD152 isoform| CD152 protein| CELIAC3| celiac disease 3| costimulatory molecule B7 receptor| costimulatory molecule B7 receptor CD152| Ctla-4| cytotoxic T-lymphocyte antigen 4| cytotoxic T lymphocyte-associated antigen 4| cytotoxic T lymphocyte-associated antigen-4| cytotoxic T-lymphocyte-associated antigen 4| cytotoxic T lymphocyte associated antigen 4 short spliced form| cytotoxic T lymphocyte-associated molecule-4| cytotoxic T-lymphocyte-associated protein 4| cytotoxic T-lymphocyte-associated serine esterase-4| Cytotoxic T-lymphocyte protein 4| cytotoxic T-lymphocyte protein 4 isoform CTLA4-TM| EGK_04712| GRD4| GSE| GW7_03350| H920_11307| I79_003018| IDDM12| insulin-dependent diabetes mellitus 12| ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4| Ly-56| M959_07257| MDA_GLEAN10017304| N300_08694| N301_02504| N302_06685| N303_08464| N305_06695| N306_10171| N307_04177| N308_00972| N309_05341| N310_10771| N311_09680| N312_07226| N320_05855| N322_01448| N324_11082| N325_10370| N326_09579| N327_08697| N328_11818| N329_11037| N330_06659| N331_00989| N332_02594| N333_10128| N334_10006| N335_04646| N336_01768| N339_08067| N340_14529| N341_00361| PAL_GLEAN10026140| PANDA_008674| sCTLA4| soluble form| transmembrane form| TREES_T100003130| Y1Q_014207| Y956_07564| ctla4

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