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  3. CTGF

CTGF (Connective tissue growth factor)

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Summary of CTGF

This gene encodes a protein that plays a role in chondrocyte proliferation and differentiation as well as cell division (R). 

0 users want this gene increased, 0 users want it decreased

The Function of CTGF

Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis.

Protein names

Recommended name:

Connective tissue growth factor

Short name:

IBP-8

Alternative name(s):

CCN family member 2
Hypertrophic chondrocyte-specific protein 24
Insulin-like growth factor-binding protein 8
IGF-binding protein 8
IGFBP-8

CTGF SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS6907728 (CTGF) ??
  2. RS6918698 (CTGF) ??
  3. RS9493150 (CTGF) ??

Top Gene-Substance Interactions

CTGF Interacts with These Diseases

Disease Score

Substances That Increase CTGF

Substances Interaction Organism Category

Substances That Decrease CTGF

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • PPAR-gamma1
  • PPAR-gamma2
  • GR
  • GR-alpha
  • GR-beta
  • NF-kappaB1
  • Sp1

Tissue specificity:

Expressed in bone marrow and thymic cells. Also expressed one of two Wilms tumors tested.

Gene Pathways:

  • Metabolism
  • Gene Expression

Molecular Function:

  • Heparin Binding
  • Insulin-Like Growth Factor Binding
  • Integrin Binding
  • Protein C-Terminus Binding

Biological Processes:

  • Aging
  • Angiogenesis
  • Cartilage Condensation
  • Cell Adhesion
  • Cell-Cell Signaling
  • Cell Differentiation
  • Cell-Matrix Adhesion
  • Chondrocyte Proliferation
  • Cytosolic Calcium Ion Transport
  • Dna Biosynthetic Process
  • Epidermis Development
  • Extracellular Matrix Constituent Secretion
  • Fibroblast Growth Factor Receptor Signaling Pathway
  • Integrin-Mediated Signaling Pathway
  • Intracellular Signal Transduction
  • Lung Development
  • Negative Regulation Of Cell Death
  • Negative Regulation Of Gene Expression
  • Ossification
  • Positive Regulation Of Cardiac Muscle Contraction
  • Positive Regulation Of Cell Activation
  • Positive Regulation Of Cell Differentiation
  • Positive Regulation Of Cell Proliferation
  • Positive Regulation Of Collagen Biosynthetic Process
  • Positive Regulation Of Cysteine-Type Endopeptidase Activity Involved In Apoptotic Process
  • Positive Regulation Of Erk1 And Erk2 Cascade
  • Positive Regulation Of G0 To G1 Transition
  • Positive Regulation Of Gene Expression
  • Positive Regulation Of Jnk Cascade
  • Positive Regulation Of Stress Fiber Assembly
  • Reactive Oxygen Species Metabolic Process
  • Regulation Of Cell Growth
  • Regulation Of Chondrocyte Differentiation
  • Response To Amino Acid
  • Response To Anoxia
  • Response To Estradiol
  • Response To Fatty Acid
  • Response To Glucose
  • Response To Mineralocorticoid
  • Response To Peptide Hormone
  • Response To Wounding
  • Tissue Homeostasis
  • Transcription Initiation From Rna Polymerase Ii Promoter
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_08550| Anapl_01827| AS27_14851| AS28_03775| CB1_106083002| CCN2| CCN family member 2| connective tissue growth factor-like protein| Connective tissue growth factor precursor (CTGF) (FISP-12 protein) (Hypertrophic chondrocyte-specific protein 24)| connective tissue growth-related protein| CTGRP| D623_10035676| EH28_21000| fibroblast inducible secreated protein| fibroblast inducible secreted protein| fisp12| fisp-12| H920_11742| Hcs24| hypertrophic chondrocyte-specific gene product 24| hypertrophic chondrocyte-specific protein 24| IBP-8| IGF-binding protein 8| igfbp8| IGFBP-8| insulin-like growth factor-binding protein 8| M91_13254| M959_14757| N300_09717| N301_15613| N302_02868| N303_15752| N305_11919| N306_14911| N308_06440| N309_06720| N311_02977| N321_13803| N322_11663| N324_06647| N325_12353| N327_12290| N328_00741| N329_06099| N331_12077| N332_14688| N333_03340| N335_11605| N336_00907| N339_09592| N340_10681| NOV2| PAL_GLEAN10018714| PANDA_012144| putative uncharacterized protein DDB_G0271606| TREES_T100016762| UY3_09337| XCTGF| Y1Q_006885| Y956_00357| Z169_09672| ctgf

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