Summary of CTGF
This gene encodes a protein that plays a role in chondrocyte proliferation and differentiation as well as cell division (R).
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The Function of CTGF
Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis.
Protein names
Recommended name:
Connective tissue growth factorShort name:
IBP-8Alternative name(s):
CCN family member 2Hypertrophic chondrocyte-specific protein 24
Insulin-like growth factor-binding protein 8
IGF-binding protein 8
IGFBP-8
- RS6907728 (CTGF) ??
- RS6918698 (CTGF) ??
- RS9493150 (CTGF) ??
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Top Gene-Substance Interactions
CTGF Interacts with These Diseases
| Disease | Score |
Substances That Increase CTGF
| Substances | Interaction | Organism | Category |
Substances That Decrease CTGF
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in bone marrow and thymic cells. Also expressed one of two Wilms tumors tested.
Gene Pathways:
Molecular Function:
Biological Processes:
- Cartilage Condensation
- Ossification
- Angiogenesis
- Regulation Of Cell Growth
- Tissue Homeostasis
- Transcription Initiation From Rna Polymerase Ii Promoter
- Cell Adhesion
- Cell-Matrix Adhesion
- Integrin-Mediated Signaling Pathway
- Cell-Cell Signaling
- Aging
- Positive Regulation Of Cell Proliferation
- Fibroblast Growth Factor Receptor Signaling Pathway
- Epidermis Development
- Response To Wounding
- Response To Glucose
- Positive Regulation Of Gene Expression
- Negative Regulation Of Gene Expression
- Cell Differentiation
- Lung Development
- Regulation Of Chondrocyte Differentiation
- Response To Estradiol
- Positive Regulation Of Collagen Biosynthetic Process
- Response To Anoxia
- Intracellular Signal Transduction
- Chondrocyte Proliferation
- Response To Amino Acid
- Positive Regulation Of Cysteine-Type Endopeptidase Activity Involved In Apoptotic Process
- Response To Peptide Hormone
- Positive Regulation Of Cell Differentiation
- Positive Regulation Of Jnk Cascade
- Positive Regulation Of Cell Activation
- Response To Mineralocorticoid
- Positive Regulation Of Stress Fiber Assembly
- Cytosolic Calcium Ion Transport
- Positive Regulation Of Cardiac Muscle Contraction
- Negative Regulation Of Cell Death
- Extracellular Matrix Constituent Secretion
- Positive Regulation Of G0 To G1 Transition
- Positive Regulation Of Erk1 And Erk2 Cascade
- Response To Fatty Acid
- Dna Biosynthetic Process
- Reactive Oxygen Species Metabolic Process