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  2. Genes
  3. CTF1

CTF1 (Cardiotrophin 1)

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The Function of CTF1

Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor.

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Protein names

Recommended name:

Cardiotrophin-1

Short name:

CT-1

CTF1 SNPs

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  1. RS11649653 (CTF1) ??

Top Gene-Substance Interactions

CTF1 Interacts with These Diseases

Disease Score

Substances That Increase CTF1

Substances Interaction Organism Category

Substances That Decrease CTF1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • p53
  • STAT3
  • NF-kappaB1
  • c-Fos
  • STAT1
  • STAT1beta
  • STAT1alpha
  • NF-1

Tissue specificity:

Highly expressed in heart, skeletal muscle, prostate and ovary. Lower levels in lung, kidney, pancreas, thymus, testis and small intestine. Little or no expression in brain, placenta, liver, spleen, colon or peripheral blood leukocytes.

Gene Pathways:

  • Cytokine-cytokine receptor interaction
  • Jak-STAT signaling pathway

Molecular Function:

  • Cytokine Activity
  • Leukemia Inhibitory Factor Receptor Binding

Biological Processes:

  • Cell-Cell Signaling
  • Cell Proliferation
  • Cell Surface Receptor Signaling Pathway
  • Leukemia Inhibitory Factor Signaling Pathway
  • Muscle Organ Development
  • Nervous System Development
  • Neuron Development
  • Positive Regulation Of Cell Proliferation
  • Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| cardiophin 1| cardiotrophin-1| cardiotrophin-2| ct1| CT-1| ctf2| PANDA_014218| Y1Q_007403| zinc finger protein 646| ZNF646| ctf1

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