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  3. CST6

CST6 (Cystatin E/M)

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The Function of CST6

Shows moderate inhibition of cathepsin B but is not active against cathepsin C.

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Protein names

Recommended name:

Cystatin-M

Alternative name(s):

Cystatin-6
Cystatin-E

Top Gene-Substance Interactions

CST6 Interacts with These Diseases

Disease Score

Substances That Increase CST6

Substances Interaction Organism Category

Substances That Decrease CST6

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • STAT3

Tissue specificity:

Restricted to the stratum granulosum of normal skin, the stratum granulosum/spinosum of psoriatic skin, and the secretory coils of eccrine sweat glands. Low expression levels are found in the nasal cavity.

Molecular Function:

  • Cysteine-Type Endopeptidase Inhibitor Activity
  • Protease Binding

Biological Processes:

  • Anatomical Structure Morphogenesis
  • Epidermis Development
  • Negative Regulation Of Cysteine-Type Endopeptidase Activity
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| cystatin 6| Cystatin-6| cystatin-E| cystatin M| Cystatin-M| cystatin M/E| cystatin N| cysteine proteinase inhibitor| D623_10030752| GW7_07183| harlequin ichthyosis| harlequin ichthysosis| ichq| M91_15911| MDA_GLEAN10017879| N28197| PAL_GLEAN10011346| PANDA_004770| TREES_T100019424| Y1Q_006804| cst6

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