The Function of CSNK2A1
Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts as an ectokinase that phosphorylates several extracellular proteins. During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV. Phosphorylates PML at 'Ser-565' and primes it for ubiquitin-mediated degradation. Plays an important role in the circadian clock function by phosphorylating ARNTL/BMAL1 at 'Ser-90' which is pivotal for its interaction with CLOCK and which controls CLOCK nuclear entry (PubMed:11239457, PubMed:11704824, PubMed:16193064, PubMed:19188443, PubMed:20625391, PubMed:22406621). Phosphorylates CCAR2 at 'Thr-454' in gastric carcinoma tissue (PubMed:24962073).
Protein names
Recommended name:
Casein kinase II subunit alphaAlternative name(s):
CK II alpha- RS204664 (CSNK2A1) ??
- RS6084946 (CSNK2A1) ??
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Top Gene-Substance Interactions
CSNK2A1 Interacts with These Diseases
| Disease | Score |
Substances That Increase CSNK2A1
| Substances | Interaction | Organism | Category |
Substances That Decrease CSNK2A1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in gastric carcinoma tissue and the expression gradually increases with the progression of the carcinoma (at protein level).
Gene Pathways:
Enzyme Regulation:
Constitutively active protein kinase whose activity is not directly affected by phosphorylation. Seems to be regulated by level of expression and localization.
Molecular Function:
- Atp Binding
- Hsp90 Protein Binding
- Protein N-Terminus Binding
- Protein Serine/Threonine Kinase Activity
- Protein Phosphatase Regulator Activity
Biological Processes:
- Apoptotic Process
- Chaperone-Mediated Protein Folding
- Mitotic Spindle Checkpoint
- Negative Regulation Of Cysteine-Type Endopeptidase Activity Involved In Apoptotic Process
- Positive Regulation Of Cell Growth
- Positive Regulation Of Cell Proliferation
- Positive Regulation Of Protein Catabolic Process
- Positive Regulation Of Wnt Signaling Pathway
- Protein Folding
- Protein Phosphorylation
- Regulation Of Signal Transduction By P53 Class Mediator
- Regulation Of Transcription, Dna-Templated
- Rhythmic Process
- Signal Transduction
- Transcription, Dna-Templated
- Wnt Signaling Pathway
- Protein Autophosphorylation