The Function of CSGALNACT1
Transfers 1,4-N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of glucuronic acid (GlcUA). Required for addition of the first GalNAc to the core tetrasaccharide linker and for elongation of chondroitin chains. Important role in chondroitin chain biosynthesis in cartilage formation and subsequent endochondral ossification (PubMed:11788602, PubMed:12163485, PubMed:12446672, PubMed:17145758). Moreover, is involved in the metabolism of aggrecan.
Protein names
Recommended name:
Chondroitin sulfate N-acetylgalactosaminyltransferase 1Alternative name(s):
CsGalNAcT-1Chondroitin beta-1,4-N-acetylgalactosaminyltransferase 1
Beta4GalNAcT-1
- RS1388941 (CSGALNACT1) ??
- RS6984449 (CSGALNACT1) ??
- RS7816924 (CSGALNACT1) ??
- RS920590 (CSGALNACT1) ??
To see your genotype, you should be logged in and have a file with your genotype uploaded.
Top Gene-Substance Interactions
Substances That Increase CSGALNACT1
| Substances | Interaction | Organism | Category |
Substances That Decrease CSGALNACT1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Ubiquitous, with the highest levels in placenta, thyroid, bladder, prostate and adrenal gland. Detected at low levels in the other tissues examined.
Gene Pathways:
Molecular Function:
- Acetylgalactosaminyltransferase Activity
- Peptidoglycan Glycosyltransferase Activity
- Glucuronosyltransferase Activity
- Metal Ion Binding
- Glucuronylgalactosylproteoglycan 4-Beta-N-Acetylgalactosaminyltransferase Activity
- Glucuronosyl-N-Acetylgalactosaminyl-Proteoglycan 4-Beta-N-Acetylgalactosaminyltransferase Activity
Biological Processes:
- Endochondral Ossification
- Nervous System Development
- Cell Recognition
- Cell Proliferation
- Anatomical Structure Morphogenesis
- Heparan Sulfate Proteoglycan Biosynthetic Process, Polysaccharide Chain Biosynthetic Process
- Udp-N-Acetylgalactosamine Metabolic Process
- Proteoglycan Biosynthetic Process
- Extracellular Matrix Organization
- Chondroitin Sulfate Biosynthetic Process
- Heparin Biosynthetic Process
- Udp-Glucuronate Metabolic Process
- Chondroitin Sulfate Proteoglycan Biosynthetic Process
- Dermatan Sulfate Proteoglycan Biosynthetic Process
- Chondroitin Sulfate Proteoglycan Biosynthetic Process, Polysaccharide Chain Biosynthetic Process
- Cartilage Development