The Function of CSGALNACT1
Transfers 1,4-N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of glucuronic acid (GlcUA). Required for addition of the first GalNAc to the core tetrasaccharide linker and for elongation of chondroitin chains. Important role in chondroitin chain biosynthesis in cartilage formation and subsequent endochondral ossification (PubMed:11788602, PubMed:12163485, PubMed:12446672, PubMed:17145758). Moreover, is involved in the metabolism of aggrecan.
Protein names
Recommended name:
Chondroitin sulfate N-acetylgalactosaminyltransferase 1Alternative name(s):
CsGalNAcT-1Chondroitin beta-1,4-N-acetylgalactosaminyltransferase 1
Beta4GalNAcT-1
- RS1388941 (CSGALNACT1) ??
- RS6984449 (CSGALNACT1) ??
- RS7816924 (CSGALNACT1) ??
- RS920590 (CSGALNACT1) ??
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Top Gene-Substance Interactions
Substances That Increase CSGALNACT1
| Substances | Interaction | Organism | Category |
Substances That Decrease CSGALNACT1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Ubiquitous, with the highest levels in placenta, thyroid, bladder, prostate and adrenal gland. Detected at low levels in the other tissues examined.
Gene Pathways:
Molecular Function:
- Acetylgalactosaminyltransferase Activity
- Glucuronosyl-N-Acetylgalactosaminyl-Proteoglycan 4-Beta-N-Acetylgalactosaminyltransferase Activity
- Glucuronosyltransferase Activity
- Glucuronylgalactosylproteoglycan 4-Beta-N-Acetylgalactosaminyltransferase Activity
- Metal Ion Binding
- Peptidoglycan Glycosyltransferase Activity
Biological Processes:
- Anatomical Structure Morphogenesis
- Cartilage Development
- Cell Proliferation
- Cell Recognition
- Chondroitin Sulfate Biosynthetic Process
- Chondroitin Sulfate Proteoglycan Biosynthetic Process
- Chondroitin Sulfate Proteoglycan Biosynthetic Process, Polysaccharide Chain Biosynthetic Process
- Dermatan Sulfate Proteoglycan Biosynthetic Process
- Endochondral Ossification
- Extracellular Matrix Organization
- Heparan Sulfate Proteoglycan Biosynthetic Process, Polysaccharide Chain Biosynthetic Process
- Heparin Biosynthetic Process
- Nervous System Development
- Proteoglycan Biosynthetic Process
- Udp-Glucuronate Metabolic Process
- Udp-N-Acetylgalactosamine Metabolic Process