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  3. CSGALNACT1

CSGALNACT1 (Chondroitin sulfate N-acetylgalactosaminyltransferase 1)

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The Function of CSGALNACT1

Transfers 1,4-N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of glucuronic acid (GlcUA). Required for addition of the first GalNAc to the core tetrasaccharide linker and for elongation of chondroitin chains. Important role in chondroitin chain biosynthesis in cartilage formation and subsequent endochondral ossification (PubMed:11788602, PubMed:12163485, PubMed:12446672, PubMed:17145758). Moreover, is involved in the metabolism of aggrecan.

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Protein names

Recommended name:

Chondroitin sulfate N-acetylgalactosaminyltransferase 1

Alternative name(s):

CsGalNAcT-1
Chondroitin beta-1,4-N-acetylgalactosaminyltransferase 1
Beta4GalNAcT-1

CSGALNACT1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS1388941 (CSGALNACT1) ??
  2. RS6984449 (CSGALNACT1) ??
  3. RS7816924 (CSGALNACT1) ??
  4. RS920590 (CSGALNACT1) ??

Top Gene-Substance Interactions

Substances That Increase CSGALNACT1

Substances Interaction Organism Category

Substances That Decrease CSGALNACT1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • GR
  • GR-alpha
  • GR-beta
  • RORalpha2
  • Meis-1
  • Meis-1b

Tissue specificity:

Ubiquitous, with the highest levels in placenta, thyroid, bladder, prostate and adrenal gland. Detected at low levels in the other tissues examined.

Gene Pathways:

  • Metabolic pathways
  • Metabolism
  • Disease
  • Glycosaminoglycan biosynthesis - chondroitin sulfate

Molecular Function:

  • Acetylgalactosaminyltransferase Activity
  • Glucuronosyl-N-Acetylgalactosaminyl-Proteoglycan 4-Beta-N-Acetylgalactosaminyltransferase Activity
  • Glucuronosyltransferase Activity
  • Glucuronylgalactosylproteoglycan 4-Beta-N-Acetylgalactosaminyltransferase Activity
  • Metal Ion Binding
  • Peptidoglycan Glycosyltransferase Activity

Biological Processes:

  • Anatomical Structure Morphogenesis
  • Cartilage Development
  • Cell Proliferation
  • Cell Recognition
  • Chondroitin Sulfate Biosynthetic Process
  • Chondroitin Sulfate Proteoglycan Biosynthetic Process
  • Chondroitin Sulfate Proteoglycan Biosynthetic Process, Polysaccharide Chain Biosynthetic Process
  • Dermatan Sulfate Proteoglycan Biosynthetic Process
  • Endochondral Ossification
  • Extracellular Matrix Organization
  • Heparan Sulfate Proteoglycan Biosynthetic Process, Polysaccharide Chain Biosynthetic Process
  • Heparin Biosynthetic Process
  • Nervous System Development
  • Proteoglycan Biosynthetic Process
  • Udp-Glucuronate Metabolic Process
  • Udp-N-Acetylgalactosamine Metabolic Process
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_00888| Anapl_03836| AS27_15631| AS28_11723| beta1,4 N-acetylgalactosaminyltransferase| beta4GalNAcT| beta4GalNAcT-1| CB1_001095066| Chgn| chondroitin beta1,4 N-acetylgalactosaminyltransferase| chondroitin beta-1,4-N-acetylgalactosaminyltransferase 1| CSGalNAcT-1| D623_10030555| EGK_18734| glucuronylgalactosylproteoglycan 4-beta-N- acetylgalactosaminyltransferase| H920_00546| M959_05180| MDA_GLEAN10024871| N300_05159| N301_16657| N302_04274| N303_07367| N305_00537| N306_07765| N309_12817| N311_02600| N320_00949| N321_09951| N322_04229| N324_03612| N326_12967| N327_05681| N328_03950| N329_12081| N330_13005| N331_00637| N332_07241| N333_13470| N334_06510| N336_06539| N339_05396| N341_04232| PAL_GLEAN10021521| PANDA_006844| RGD1307618| TREES_T100017940| UY3_09896| Y1Q_024338| Y956_00898| Z169_10003| csgalnact1

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