The Function of CSF3
Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes.
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Protein names
Recommended name:
Granulocyte colony-stimulating factorShort name:
G-CSFAlternative name(s):
PluripoietinFilgrastim
Lenograstim
- RS4794822 (CSF3) ??
- RS8078723 (CSF3) ??
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Top Gene-Substance Interactions
CSF3 Interacts with These Diseases
| Disease | Score |
Substances That Increase CSF3
| Substances | Interaction | Organism | Category |
Substances That Decrease CSF3
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Gene Pathways:
Caution:
PubMed:2420009 misquotes the gene name as "CSF1".
Molecular Function:
- Cytokine Activity
- Granulocyte Colony-Stimulating Factor Receptor Binding
- Growth Factor Activity
- Enzyme Binding
Biological Processes:
- Immune Response
- Multicellular Organism Development
- Positive Regulation Of Cell Proliferation
- Positive Regulation Of Phosphatidylinositol 3-Kinase Signaling
- Cytokine-Mediated Signaling Pathway
- Positive Regulation Of Actin Filament Polymerization
- Granulocyte Differentiation
- Positive Regulation Of Peptidyl-Serine Phosphorylation
- Positive Regulation Of Transcription Factor Import Into Nucleus
- Response To Ethanol
- Positive Regulation Of Myeloid Cell Differentiation
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Positive Regulation Of Peptidyl-Tyrosine Phosphorylation
- Positive Regulation Of Protein Kinase B Signaling
- Cellular Response To Lipopolysaccharide
- Cellular Response To Cytokine Stimulus
- Negative Regulation Of Neuron Death
- Positive Regulation Of Actin Cytoskeleton Reorganization