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  3. CSF3

CSF3 (Colony stimulating factor 3)

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The Function of CSF3

Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes.

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Protein names

Recommended name:

Granulocyte colony-stimulating factor

Short name:

G-CSF

Alternative name(s):

Pluripoietin
Filgrastim
Lenograstim

CSF3 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS4794822 (CSF3) ??
  2. RS8078723 (CSF3) ??

Top Gene-Substance Interactions

CSF3 Interacts with These Diseases

Disease Score

Substances That Increase CSF3

Substances Interaction Organism Category

Substances That Decrease CSF3

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • GR
  • AP-1
  • c-Jun
  • STAT3
  • STAT5A
  • STAT1
  • STAT1beta
  • STAT1alpha
  • AML1a

Gene Pathways:

  • Cytokine-cytokine receptor interaction
  • Hematopoietic cell lineage
  • Malaria
  • Jak-STAT signaling pathway

Caution:

PubMed:2420009 misquotes the gene name as "CSF1".

Molecular Function:

  • Cytokine Activity
  • Enzyme Binding
  • Granulocyte Colony-Stimulating Factor Receptor Binding
  • Growth Factor Activity

Biological Processes:

  • Cellular Response To Cytokine Stimulus
  • Cellular Response To Lipopolysaccharide
  • Cytokine-Mediated Signaling Pathway
  • Granulocyte Differentiation
  • Immune Response
  • Multicellular Organism Development
  • Negative Regulation Of Neuron Death
  • Positive Regulation Of Actin Cytoskeleton Reorganization
  • Positive Regulation Of Actin Filament Polymerization
  • Positive Regulation Of Cell Proliferation
  • Positive Regulation Of Myeloid Cell Differentiation
  • Positive Regulation Of Peptidyl-Serine Phosphorylation
  • Positive Regulation Of Peptidyl-Tyrosine Phosphorylation
  • Positive Regulation Of Phosphatidylinositol 3-Kinase Signaling
  • Positive Regulation Of Protein Kinase B Signaling
  • Positive Regulation Of Transcription Factor Import Into Nucleus
  • Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Response To Ethanol
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| colony-stimulating factor| CSF| A306_14853| AS27_15431| C17orf33| CB1_000261006| colony stimulating factor 3 (granulocyte)| colony stimulating factor 3 isoform b precursor-like protein| CSF3OS| Csfg| D623_10030371| EH28_00995| filgrastim| GCSF| G-CSF| granulocyte colony-stimulating factor| granulocyte-colony stimulating factor| GW7_09608| lenograstim| M91_05291| mature cMGF| MGF| MGI-IG| myelomonocytic growth factor| N303_15436| PAL_GLEAN10019604| PANDA_019564| pluripoietin| TREES_T100004480| Y1Q_015119| Y956_08256| csf3

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