Summary of CSF2RA
This gene encodes a subunit of a cytokine that controls the production, differentiation, and function of granulocytes and macrophages (R).
The Function of CSF2RA
Low affinity receptor for granulocyte-macrophage colony-stimulating factor. Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells.
Protein names
Recommended name:
Granulocyte-macrophage colony-stimulating factor receptor subunit alphaAlternative name(s):
GM-CSF-R-alphaGMCSFR-alpha
GMR-alpha
CDw116
CD antigen CD116
- RS4129148 (CSF2RA) ??
To see your genotype, you should be logged in and have a file with your genotype uploaded.
Top Gene-Substance Interactions
Substances That Increase CSF2RA
| Substances | Interaction | Organism | Category |
Substances That Decrease CSF2RA
| Substances | Interaction | Organism | Category |
Advanced Summary
Covered on Genetics Home Reference: surfactant dysfunctionFrom UniProt: Pulmonary surfactant metabolism dysfunction 4 (SMDP4): A rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress. [MIM:300770]
From NCBI Gene: The protein encoded by this gene is the alpha subunit of the heterodimeric receptor for colony stimulating factor 2, a cytokine which controls the production, differentiation, and function of granulocytes and macrophages. The encoded protein is a member of the cytokine family of receptors. This gene is found in the pseudoautosomal region (PAR) of the X and Y chromosomes. Multiple transcript variants encoding different isoforms have been found for this gene, with some of the isoforms being membrane-bound and others being soluble. [provided by RefSeq, Jul 2008] From UniProt: Low affinity receptor for granulocyte-macrophage colony-stimulating factor. Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells.
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
- Cytokine Receptor Activity
- Protein Tyrosine Kinase Activity
- Ras Guanyl-Nucleotide Exchange Factor Activity
- Receptor Activity
- Granulocyte Colony-Stimulating Factor Receptor Activity
Biological Processes:
- Cellular Protein Metabolic Process
- Mapk Cascade
- Cellular Response To Granulocyte Macrophage Colony-Stimulating Factor Stimulus