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  3. CSF2RA

CSF2RA (Colony stimulating factor 2 receptor alpha subunit)

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Summary of CSF2RA

This gene encodes a subunit of a cytokine that controls the production, differentiation, and function of granulocytes and macrophages (R). 

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The Function of CSF2RA

Low affinity receptor for granulocyte-macrophage colony-stimulating factor. Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells.

Protein names

Recommended name:

Granulocyte-macrophage colony-stimulating factor receptor subunit alpha

Alternative name(s):

GM-CSF-R-alpha
GMCSFR-alpha
GMR-alpha
CDw116
CD antigen CD116

CSF2RA SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS4129148 (CSF2RA) ??

Top Gene-Substance Interactions

Substances That Increase CSF2RA

Substances Interaction Organism Category

Substances That Decrease CSF2RA

Substances Interaction Organism Category

Advanced Summary

     Covered on Genetics Home Reference: surfactant dysfunctionFrom UniProt: Pulmonary surfactant metabolism dysfunction 4 (SMDP4): A rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress. [MIM:300770]

     From NCBI Gene: The protein encoded by this gene is the alpha subunit of the heterodimeric receptor for colony stimulating factor 2, a cytokine which controls the production, differentiation, and function of granulocytes and macrophages. The encoded protein is a member of the cytokine family of receptors. This gene is found in the pseudoautosomal region (PAR) of the X and Y chromosomes. Multiple transcript variants encoding different isoforms have been found for this gene, with some of the isoforms being membrane-bound and others being soluble. [provided by RefSeq, Jul 2008] From UniProt: Low affinity receptor for granulocyte-macrophage colony-stimulating factor. Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • GR
  • GR-alpha
  • GR-beta
  • Max
  • c-Myc

Gene Pathways:

  • Immune System
  • Pathways in cancer
  • Cytokine-cytokine receptor interaction
  • Jak-STAT signaling pathway
  • Hematopoietic cell lineage

Molecular Function:

  • Cytokine Receptor Activity
  • Protein Tyrosine Kinase Activity
  • Ras Guanyl-Nucleotide Exchange Factor Activity
  • Receptor Activity
  • Granulocyte Colony-Stimulating Factor Receptor Activity

Biological Processes:

  • Cellular Protein Metabolic Process
  • Mapk Cascade
  • Cellular Response To Granulocyte Macrophage Colony-Stimulating Factor Stimulus

Drug Bank:

  • Sargramostim
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

CD116| CD116 antigen| CDw116| colony stimulating factor 2 receptor, alpha| colony stimulating factor 2 receptor alpha chain| colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)| CSF2R| CSF2RAX| CSF2RAY| CSF2RX| CSF2RY| Csfgmra| GMCSFR| GM-CSFR| GM-CSF-Ra| GM-CSFRalpha| GM-CSF-R-alpha| GMCSFR-alpha| GM-CSF receptor alpha subunit| GMR| GMR-alpha| granulocyte-macrophage colony-stimulating factor receptor alpha chain| Granulocyte-macrophage colony-stimulating factor receptor subunit alpha| granulocyte-macrophage colony-stimulating factor receptor subunit alpha-like| granulocyte-macrophage colony stimulating receptor alpha| H920_15838| M91_13494| N331_11810| PAL_GLEAN10002370| SMDP4| csf2ra

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