Summary of CSF1
This gene encodes a protein thatcontrols the production, differentiation, and function of macrophages (R).
The Function of CSF1
Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance.
Protein names
Recommended name:
Macrophage colony-stimulating factor 1Short name:
MCSFAlternative name(s):
CSF-1M-CSF
Lanimostim
- RS10494112 (CSF1) ??
- RS333960 (CSF1) ??
- RS333970 (CSF1) ??
- RS484959 (CSF1) ??
- RS6537883 (CSF1) ??
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Top Gene-Substance Interactions
CSF1 Interacts with These Diseases
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Substances That Increase CSF1
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Substances That Decrease CSF1
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Advanced Summary
From UniProt: Aberrant expression of CSF1 or CSF1R may play a role in inflammatory diseases, such as rheumatoid arthritis, glomerulonephritis, atherosclerosis, and allograft rejection. Aberrant expression of CSF1 or CSF1R can promote cancer cell proliferation, invasion and formation of metastases. Overexpression of CSF1 or CSF1R is observed in a significant percentage of breast, ovarian, prostate, and endometrial cancers.
From NCBI Gene: The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of macrophages. The active form of the protein is found extracellularly as a disulfide-linked homodimer, and is thought to be produced by proteolytic cleavage of membrane-bound precursors. The encoded protein may be involved in development of the placenta. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011] From UniProt: Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance.
Conditions with Increased Gene Activity
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Conditions with Decreased Gene Activity
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
- Cytokine Activity
- Macrophage Colony-Stimulating Factor Receptor Binding
- Growth Factor Activity
- Protein Homodimerization Activity
Biological Processes:
- Ossification
- Positive Regulation Of Cell-Matrix Adhesion
- Osteoclast Proliferation
- Developmental Process Involved In Reproduction
- Inflammatory Response
- Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
- Cell Proliferation
- Positive Regulation Of Cell Proliferation
- Positive Regulation Of Gene Expression
- Regulation Of Macrophage Derived Foam Cell Differentiation
- Positive Regulation Of Macrophage Derived Foam Cell Differentiation
- Positive Regulation Of Macrophage Chemotaxis
- Hemopoiesis
- Cell Differentiation
- Macrophage Differentiation
- Regulation Of Ossification
- Osteoclast Differentiation
- Positive Regulation Of Cell Migration
- Positive Regulation Of Cellular Protein Metabolic Process
- Positive Regulation Of Mononuclear Cell Proliferation
- Macrophage Colony-Stimulating Factor Signaling Pathway
- Positive Regulation Of Multicellular Organism Growth
- Monocyte Activation
- Odontogenesis
- Positive Regulation Of Odontogenesis Of Dentin-Containing Tooth
- Innate Immune Response
- Positive Regulation Of Macrophage Differentiation
- Positive Regulation Of Monocyte Differentiation
- Positive Regulation Of Osteoclast Differentiation
- Positive Regulation Of Protein Kinase Activity
- Positive Regulation Of Ras Protein Signal Transduction
- Homeostasis Of Number Of Cells Within A Tissue
- Branching Involved In Mammary Gland Duct Morphogenesis
- Mammary Gland Fat Development
- Mammary Duct Terminal End Bud Growth
- Positive Regulation Of Macrophage Colony-Stimulating Factor Signaling Pathway
- Positive Regulation Of Microglial Cell Migration