Summary of CRH
The CRH gene codes for corticotropin-releasing hormone (CRH). CRH is the first hormone of the hypothalamic-pituitary-adrenal (HPA) axis, which is activated in response to stress [R, R].
CRH plays a role in [R, R, R]:
- Stress
- Inflammation
- Gut permeability
Protein names
Recommended name:
CorticoliberinShort name:
CRFAlternative name(s):
Corticotropin-releasing factorCorticotropin-releasing hormone
- RS12721510 (CRH) ??
- RS6999100 (CRH) ??
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Top Gene-Substance Interactions
CRH Interacts with These Diseases
| Disease | Score |
Substances That Increase CRH
| Substances | Interaction | Organism | Category |
Substances That Decrease CRH
| Substances | Interaction | Organism | Category |
Advanced Summary
Read: Why Your Health Problems Worsen After Stress: The Role of CRH
Corticotropin Releasing Hormone (CRH) is the first hormone of the HPA axis , and its released by the hypothalamus. CRH->ACTH->Cortisol.
I suspect that CRH is playing the largest role in gut permeability, which is a significant cause of stress-induced food sensitivities.
The stress-response is classically divided into three categories: behavioral, autonomic, and hormonal responses.
CRH is believed to be involved in all three stress-responses, involving different brain regions (R).
Behavioral responses include muscle readiness, fear, anxiety, heightened vigilance, clarity of thought, decreased appetite, and decreased libido (R).
CRH neurons connect to the brainstem, which is responsible for autonomic responses (R).
The hypothalamus is just above the brain stem and acts as an integrator for autonomic functions (receiving input from the limbic system to do so) (R).
Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile.
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Produced by the hypothalamus and placenta.
Molecular Function:
- Receptor Binding
- Hormone Activity
- Neuropeptide Hormone Activity
- Corticotropin-Releasing Hormone Activity
Biological Processes:
- Positive Regulation Of Protein Phosphorylation
- Synaptic Transmission, Dopaminergic
- Glucocorticoid Biosynthetic Process
- Inflammatory Response
- Signal Transduction
- Chemical Synaptic Transmission
- Female Pregnancy
- Parturition
- Learning Or Memory
- Positive Regulation Of Cell Proliferation
- Associative Learning
- Hormone-Mediated Apoptotic Signaling Pathway
- Positive Regulation Of Gene Expression
- Negative Regulation Of Gene Expression
- Negative Regulation Of Norepinephrine Secretion
- Positive Regulation Of Circadian Sleep/Wake Cycle, Wakefulness
- Positive Regulation Of Cell Death
- Regulation Of Serotonin Secretion
- Diterpenoid Metabolic Process
- Hypothalamus Development
- Lung Development
- Adrenal Gland Development
- Positive Regulation Of Camp Biosynthetic Process
- Negative Regulation Of Epinephrine Secretion
- Negative Regulation Of Luteinizing Hormone Secretion
- Locomotory Exploration Behavior
- Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
- Response To Immobilization Stress
- Negative Regulation Of Circadian Sleep/Wake Cycle, Rem Sleep
- Response To Estrogen
- Response To Ethanol
- Response To Ether
- Negative Regulation Of Blood Pressure
- Response To Pain
- Ion Homeostasis
- Response To Corticosterone
- Positive Regulation Of Corticotropin Secretion
- Positive Regulation Of Cortisol Secretion
- Long-Term Synaptic Potentiation
- Positive Regulation Of Digestive System Process
- Negative Regulation Of Cell Death
- Negative Regulation Of Glucagon Secretion
- Cellular Response To Cocaine
- Cellular Response To Dexamethasone Stimulus
- Positive Regulation Of Calcium Ion Import
- Regulation Of N-Methyl-D-Aspartate Selective Glutamate Receptor Activity
- Positive Regulation Of Corticosterone Secretion
- Positive Regulation Of Behavioral Fear Response
Drug Bank:
- Corticotropin