• Navigation
  • Register My DNA Kit
  • Features
  • Pricing
  • FAQ
  • About
  • Labs
  • Login
  • Get started
  1. Home
  2. Genes
  3. CRH

CRH (Corticotropin releasing hormone)

Loading...

Summary of CRH

Corticotropin Releasing Hormone (CRH) is a hormone released by the hypothalamus. It plays a role in gut permeability, stress response, and behavioral responses (R).  

It is the first hormone of the HPA axis, CRH is first released, then ACTH, and then cortisol . 

It's better to have this gene decreased most of the time.
0 users want this gene increased, 0 users want it decreased

Protein names

Recommended name:

Corticoliberin

Short name:

CRF

Alternative name(s):

Corticotropin-releasing factor
Corticotropin-releasing hormone

CRH SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS12721510 (CRH) ??
  2. RS6999100 (CRH) ??

Top Gene-Substance Interactions

CRH Interacts with These Diseases

Disease Score

Substances That Increase CRH

Substances Interaction Organism Category

Substances That Decrease CRH

Substances Interaction Organism Category

Advanced Summary

Read: Why Your Health Problems Worsen After Stress: The Role of CRH

Corticotropin Releasing Hormone (CRH) is the first hormone of the HPA axis , and its released by the hypothalamus.  CRH->ACTH->Cortisol.

I suspect that CRH is playing the largest role in gut permeability, which is a significant cause of stress-induced food sensitivities.

The stress-response is classically divided into three categories: behavioral, autonomic, and hormonal responses.

CRH is believed to be involved in all three stress-responses, involving different brain regions (R).

Behavioral responses include muscle readiness, fear, anxiety, heightened vigilance, clarity of thought, decreased appetite, and decreased libido (R).

CRH neurons connect to the brainstem, which is responsible for autonomic responses (R).

The hypothalamus is just above the brain stem and acts as an integrator for autonomic functions (receiving input from the limbic system to do so) (R).

Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • GR
  • GR-alpha
  • GR-beta
  • CREB
  • deltaCREB

Tissue specificity:

Produced by the hypothalamus and placenta.

Gene Pathways:

  • Signal Transduction
  • Neuroactive ligand-receptor interaction
  • Long-term depression

Molecular Function:

  • Corticotropin-Releasing Hormone Activity
  • Hormone Activity
  • Neuropeptide Hormone Activity
  • Receptor Binding

Biological Processes:

  • Adrenal Gland Development
  • Associative Learning
  • Cellular Response To Cocaine
  • Cellular Response To Dexamethasone Stimulus
  • Chemical Synaptic Transmission
  • Diterpenoid Metabolic Process
  • Female Pregnancy
  • Glucocorticoid Biosynthetic Process
  • Hormone-Mediated Apoptotic Signaling Pathway
  • Hypothalamus Development
  • Inflammatory Response
  • Ion Homeostasis
  • Learning Or Memory
  • Locomotory Exploration Behavior
  • Long-Term Synaptic Potentiation
  • Lung Development
  • Negative Regulation Of Blood Pressure
  • Negative Regulation Of Cell Death
  • Negative Regulation Of Circadian Sleep/Wake Cycle, Rem Sleep
  • Negative Regulation Of Epinephrine Secretion
  • Negative Regulation Of Gene Expression
  • Negative Regulation Of Glucagon Secretion
  • Negative Regulation Of Luteinizing Hormone Secretion
  • Negative Regulation Of Norepinephrine Secretion
  • Parturition
  • Positive Regulation Of Behavioral Fear Response
  • Positive Regulation Of Calcium Ion Import
  • Positive Regulation Of Camp Biosynthetic Process
  • Positive Regulation Of Cell Death
  • Positive Regulation Of Cell Proliferation
  • Positive Regulation Of Circadian Sleep/Wake Cycle, Wakefulness
  • Positive Regulation Of Corticosterone Secretion
  • Positive Regulation Of Corticotropin Secretion
  • Positive Regulation Of Cortisol Secretion
  • Positive Regulation Of Digestive System Process
  • Positive Regulation Of Gene Expression
  • Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
  • Positive Regulation Of Protein Phosphorylation
  • Regulation Of N-Methyl-D-Aspartate Selective Glutamate Receptor Activity
  • Regulation Of Serotonin Secretion
  • Response To Corticosterone
  • Response To Estrogen
  • Response To Ethanol
  • Response To Ether
  • Response To Immobilization Stress
  • Response To Pain
  • Signal Transduction
  • Synaptic Transmission, Dopaminergic

Drug Bank:

  • Corticotropin
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| AS27_10315| CB1_002337023| Corticoliberin| corticoliberin preproprotein| corticotrophin-releasing factor| corticotropin releasing factor| corticotropin-releasing factor| Corticotropin-releasing hormone| crf| CRH1| crh-a| crh-b| EH28_16717| Endorpholiberin| GW7_07853| H920_18292| MDA_GLEAN10000424| N300_08428| N301_15765| N303_14714| N305_03279| N307_01895| N310_02671| N312_08795| N321_00057| N322_00271| N324_09516| N325_09160| N327_08753| N330_03351| N331_02817| N334_00384| N340_07923| novel protein similar to corticotropin releasing hormone (crh)| PAL_GLEAN10019302| putative corticotropin releasing hormone| TREES_T100006596| Y956_01584| crh

Policies

  • Terms of Service
  • Platform Consent
  • Privacy Policy
  • Disclaimer

About

  • Customer Support
  • Our Team
  • Affiliate Program

Navigation

  • Homepage
  • DNA Wellness Reports
  • Personalized Genetics Blog
  • Register your DNA Test Kit
  • Login
  • Careers
GET STARTED
  • SelfDecode is a personalized health report service, which enables users to obtain detailed information and reports based on their genome. SelfDecode does not treat, diagnose or cure any conditions, but is for informational and educational purposes alone.
SelfDecode © 2021 All Rights Reserved