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  3. CREB1

CREB1 (CAMP responsive element binding protein 1)

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Summary of CREB1

This gene encodes a protein that induces transcription of genes in response to the cAMP pathway. Mutations can cause thyroid problems (R). 

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The Function of CREB1

Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells.

Protein names

Recommended name:

Cyclic AMP-responsive element-binding protein 1

Short name:

CREB-1

Alternative name(s):

cAMP-responsive element-binding protein 1

CREB1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS10932194 (CREB1) ??
  2. RS17203016 (CREB1) ??
  3. RS2253206 (CREB1) ??
  4. RS2254137 (CREB1) ??
  5. RS2360969 (CREB1) ??
  6. RS4675690 (CREB1) ??

Top Gene-Substance Interactions

CREB1 Interacts with These Diseases

Disease Score

Substances That Increase CREB1

Substances Interaction Organism Category

Substances That Decrease CREB1

Substances Interaction Organism Category

Advanced Summary

     From NCBI Gene: Angiomatoid fibrous histiocytomaFrom UniProt: A CREB1 mutation has been found in a patient with multiple congenital anomalies consisting of agenesis of the corpus callosum, cerebellar hypoplasia, severe neonatal respiratory distress refractory to surfactant, thymus hypoplasia, and thyroid follicular hypoplasia. Angiomatoid fibrous histiocytoma (AFH): A distinct variant of malignant fibrous histiocytoma that typically occurs in children and adolescents and is manifest by nodular subcutaneous growth. Characteristic microscopic features include lobulated sheets of histiocyte-like cells intimately associated with areas of hemorrhage and cystic pseudovascular spaces, as well as a striking cuffing of inflammatory cells, mimicking a lymph node metastasis. [MIM:612160]

     From NCBI Gene: This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in several transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016] From UniProt: Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • CREB
  • AP-1
  • c-Jun
  • deltaCREB
  • C/EBPbeta
  • C/EBPalpha
  • Sp1
  • c-Fos

Gene Pathways:

  • Disease
  • Immune System
  • Signal Transduction
  • Melanogenesis
  • Tuberculosis
  • Prostate cancer
  • Osteoclast differentiation
  • TRAF6 Mediated Induction of proinflammatory cytokines
  • Antigen processing and presentation
  • Neuronal System
  • Vasopressin-regulated water reabsorption
  • Huntington's disease
  • Organelle biogenesis and maintenance

Molecular Function:

  • Camp Response Element Binding
  • Enzyme Binding
  • Rna Polymerase Ii Activating Transcription Factor Binding
  • Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Dna Binding
  • Rna Polymerase Ii Distal Enhancer Sequence-Specific Dna Binding
  • Transcriptional Activator Activity, Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Binding
  • Transcriptional Activator Activity, Rna Polymerase Ii Transcription Factor Binding
  • Transcription Cofactor Activity
  • Transcription Factor Activity, Rna Polymerase Ii Distal Enhancer Sequence-Specific Binding
  • Transcription Factor Activity, Sequence-Specific Dna Binding
  • Identical Protein Binding

Biological Processes:

  • Aging
  • Axon Guidance
  • Cellular Response To Fatty Acid
  • Cellular Response To Hepatocyte Growth Factor Stimulus
  • Cellular Response To Insulin-Like Growth Factor Stimulus
  • Cellular Response To Nerve Growth Factor Stimulus
  • Cellular Response To Platelet-Derived Growth Factor Stimulus
  • Cellular Response To Zinc Ion
  • Chemotaxis To Arachidonic Acid
  • Circadian Rhythm
  • Lactation
  • Lung Saccule Development
  • Memory
  • Negative Regulation Of Neuron Death
  • Negative Regulation Of Transcription By Competitive Promoter Binding
  • Pituitary Gland Development
  • Positive Regulation Of Apoptotic Process
  • Positive Regulation Of Cardiac Muscle Tissue Development
  • Positive Regulation Of Fat Cell Differentiation
  • Positive Regulation Of Hormone Secretion
  • Positive Regulation Of Lipid Biosynthetic Process
  • Positive Regulation Of Long-Term Synaptic Potentiation
  • Positive Regulation Of Multicellular Organism Growth
  • Positive Regulation Of Osteoclast Differentiation
  • Positive Regulation Of Rna Polymerase Ii Transcriptional Preinitiation Complex Assembly
  • Positive Regulation Of Transcription, Dna-Templated
  • Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Positive Regulation Of Transforming Growth Factor Beta3 Production
  • Protein Phosphorylation
  • Protein Stabilization
  • Regulation Of Cell Size
  • Regulation Of Circadian Rhythm
  • Regulation Of Fibroblast Proliferation
  • Regulation Of Glial Cell Proliferation
  • Response To Glucagon
  • Response To Hypoxia
  • Response To L-Glutamate
  • Response To Nicotine
  • Response To Organic Substance
  • Secretory Granule Organization
  • Signal Transduction
  • Transforming Growth Factor Beta Receptor Signaling Pathway
  • Type I Pneumocyte Differentiation
  • Viral Process
  • Visual Learning

Drug Bank:

  • Naloxone
  • Adenosine Monophosphate
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| Cyclic AMP-responsive element-binding protein 1| A306_01976| active transcription factor CREB| AS27_04048| AS28_03264| AV083133| cAMP response element binding protein| cAMP response element-binding protein| cAMP response element binding protein 1| cAMP-response element-binding protein-1| CB1_000593020| Creb| CREB-1| cyclic adenosine 3',5'-monophosphate response element-binding protein CREB| cyclic AMP response element binding protein| cyclic AMP-responsive DNA-binding protein| cyclic AMP-responsive element-binding protein 1-like protein| cyclic AMP-responsive element binding protein, delta| EGK_04729| GW7_17278| I79_014474| M959_04828| MDA_GLEAN10017332| N301_02480| N302_06667| N303_08487| N305_06713| N308_11114| N309_08071| N311_08550| N312_03663| N320_06759| N321_05614| N322_08775| N325_03080| N326_08789| N327_03767| N328_09101| N329_08505| N330_09297| N332_09372| N334_13688| N335_09783| N339_10612| N340_00933| N341_11515| PAL_GLEAN10026161| PANDA_006536| transactivator protein| TREES_T100000267| Y1Q_022113| Y956_07543| Y protein| Z169_11451| creb1

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