From UniProt: A CREB1 mutation has been found in a patient with multiple congenital anomalies consisting of agenesis of the corpus callosum, cerebellar hypoplasia, severe neonatal respiratory distress refractory to surfactant, thymus hypoplasia, and thyroid follicular hypoplasia. Angiomatoid fibrous histiocytoma (AFH): A distinct variant of malignant fibrous histiocytoma that typically occurs in children and adolescents and is manifest by nodular subcutaneous growth. Characteristic microscopic features include lobulated sheets of histiocyte-like cells intimately associated with areas of hemorrhage and cystic pseudovascular spaces, as well as a striking cuffing of inflammatory cells, mimicking a lymph node metastasis. [MIM:612160]

From NCBI Gene: This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in several transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016] From UniProt: Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells.

The following transcription factors affect gene expression:

• CREB
• AP-1
• c-Jun
• deltaCREB
• C/EBPbeta
• C/EBPalpha
• Sp1
• c-Fos

Molecular Function:

• Camp Response Element Binding
• Enzyme Binding
• Rna Polymerase Ii Activating Transcription Factor Binding
• Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Dna Binding
• Rna Polymerase Ii Distal Enhancer Sequence-Specific Dna Binding
• Transcriptional Activator Activity, Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Binding
• Transcriptional Activator Activity, Rna Polymerase Ii Transcription Factor Binding
• Transcription Cofactor Activity
• Transcription Factor Activity, Rna Polymerase Ii Distal Enhancer Sequence-Specific Binding
• Transcription Factor Activity, Sequence-Specific Dna Binding
• Identical Protein Binding

Biological Processes:

• Aging
• Axon Guidance
• Cellular Response To Fatty Acid
• Cellular Response To Hepatocyte Growth Factor Stimulus
• Cellular Response To Insulin-Like Growth Factor Stimulus
• Cellular Response To Nerve Growth Factor Stimulus
• Cellular Response To Platelet-Derived Growth Factor Stimulus
• Cellular Response To Zinc Ion
• Chemotaxis To Arachidonic Acid
• Circadian Rhythm
• Lactation
• Lung Saccule Development
• Memory
• Negative Regulation Of Neuron Death
• Negative Regulation Of Transcription By Competitive Promoter Binding
• Pituitary Gland Development
• Positive Regulation Of Apoptotic Process
• Positive Regulation Of Cardiac Muscle Tissue Development
• Positive Regulation Of Fat Cell Differentiation
• Positive Regulation Of Hormone Secretion
• Positive Regulation Of Lipid Biosynthetic Process
• Positive Regulation Of Long-Term Synaptic Potentiation
• Positive Regulation Of Multicellular Organism Growth
• Positive Regulation Of Osteoclast Differentiation
• Positive Regulation Of Rna Polymerase Ii Transcriptional Preinitiation Complex Assembly
• Positive Regulation Of Transcription, Dna-Templated
• Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
• Positive Regulation Of Transforming Growth Factor Beta3 Production
• Protein Phosphorylation
• Protein Stabilization
• Regulation Of Cell Size
• Regulation Of Circadian Rhythm
• Regulation Of Fibroblast Proliferation
• Regulation Of Glial Cell Proliferation
• Response To Glucagon
• Response To Hypoxia
• Response To L-Glutamate
• Response To Nicotine
• Response To Organic Substance
• Secretory Granule Organization
• Signal Transduction
• Transforming Growth Factor Beta Receptor Signaling Pathway
• Type I Pneumocyte Differentiation
• Viral Process
• Visual Learning

Drug Bank:

• Naloxone
• Adenosine Monophosphate