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  3. COX2

COX2 (Cytochrome c oxidase subunit II)

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Summary of COX2

Cyclooxygenase-2 (COX-2) or PTGS2, is an enzyme mainly associated with responses to biological stresses such as infection and inflammation (R,R2). It's responsible for inflammation and pain. COX-2 has been shown to cause cancer, inflammatory diseases such as rheumatoid arthritis, and neuropsychiatric diseases [R]. 

PTGS2 (COX-2), converts arachidonic acid (AA) to prostaglandin endoperoxide H2.

COX-2 inhibitors have been shown to provide relief from pain and inflammation related to the enzyme.

Several studies indicate that PGTS2 is associated with an increasing in colorectal (R,R2,R3), prostate (R) and breast cancer risk (R). In particular, PTGS2 is probably involved in tumor proliferation and growth, in the formation of metastases and in the resistance of cancer cells to programmed death (R1,R2,R3).

Recent studies suggest that PTGS2 is linked with the development of type 2 diabetes (R) and with the promotion of eye disease in diabetes (R).

Dysfunction of this gene can lead to oxidative stress and harm your body (R). On the other hand, overexpression of this gene can lead to cell death and cause heart problems (R).

It's better to have this gene decreased most of the time.
0 users want this gene increased, 0 users want it decreased

Protein names

Recommended name:

Prostaglandin G/H synthase 2

Short name:

COX-2

Alternative name(s):

Cyclooxygenase-2
PHS II
Prostaglandin H2 synthase 2
PGH synthase 2
PGHS-2
Prostaglandin-endoperoxide synthase 2

COX2 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS20417 (COX2) ??
  2. RS5275 (COX2) ??

Top Gene-Substance Interactions

COX2 Interacts with These Diseases

Disease Score

Fixes

Nonsteroidal anti-inflammatory drugs (NSAIDs) have been developed to prevent the effects of COX-2, but there are many side effects to the drugs. Rather than risking heart disease, strokes, or worse, naturally occurring COX-2 inhibitors should be looked to as an alternative to preventing health problems [R].

Substances That Increase COX2

Substances Interaction Organism Category

Substances That Decrease COX2

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

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