• Navigation
  • Register My DNA Kit
  • Features
  • Pricing
  • FAQ
  • About
  • Labs
  • Login
  • Get started
  1. Home
  2. Genes
  3. COLEC12

COLEC12 (Collectin subfamily member 12)

Loading...

The Function of COLEC12

Scavenger receptor that displays several functions associated with host defense. Promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast. Mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. Binds to several carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells. Binds also to sialyl Lewis X or a trisaccharide and asialo-orosomucoid (ASOR). May also play a role in the clearance of amyloid beta in Alzheimer disease.

0 users want this gene increased, 0 users want it decreased

Protein names

Recommended name:

Collectin-12

Short name:

CL-P1

Alternative name(s):

Collectin placenta protein 1
hCL-P1
Nurse cell scavenger receptor 2
Scavenger receptor class A member 4
Scavenger receptor with C-type lectin

COLEC12 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS621636 (COLEC12) ??
  2. RS644435 (COLEC12) ??
  3. RS7226677 (COLEC12) ??

Top Gene-Substance Interactions

Substances That Increase COLEC12

Substances Interaction Organism Category

Substances That Decrease COLEC12

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • FOXO3
  • FOXO3a
  • GATA-1
  • FOXF2
  • Nkx3-1
  • FOXO3b

Tissue specificity:

Expressed in perivascular macrophages. Expressed in plaques-surrounding reactive astrocytes and in perivascular astrocytes associated with cerebral amyloid angiopathy (CAA) in the temporal cortex of Alzheimer patient (at protein level). Strongly expressed in placenta. Moderately expressed in heart, skeletal muscle, small intestine and lung. Weakly expressed in brain, colon, thymus and kidney. Expressed in nurse-like cells. Expressed in reactive astrocytes and vascular/perivascular cells in the brain of Alzheimer patient.

Gene Pathways:

  • Phagosome

Molecular Function:

  • Galactose Binding
  • Low-Density Lipoprotein Particle Binding
  • Metal Ion Binding
  • Scavenger Receptor Activity
  • Signaling Pattern Recognition Receptor Activity

Biological Processes:

  • Carbohydrate Mediated Signaling
  • Cellular Response To Exogenous Dsrna
  • Defense Response
  • Innate Immune Response
  • Phagocytosis, Recognition
  • Positive Regulation Of Cell Adhesion Molecule Production
  • Protein Homooligomerization
  • Receptor-Mediated Endocytosis
  • Toll-Like Receptor 3 Signaling Pathway
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| AS27_05898| AS28_09403| cCL-3| CL-3| CLP1| CL-P1| Collectin-12| collectin 1 precursor CL-3| collectin-3| collectin placenta 1| collectin placenta protein 1| collectin sub-family member 12| H920_11516| hCL-P1| M91_00552| M959_00960| MDA_GLEAN10025303| N300_12945| N301_10808| N302_01010| N303_12951| N305_03558| N306_04834| N307_07574| N309_08173| N310_13823| N311_02493| N312_04564| N320_10931| N321_01031| N322_13487| N324_07760| N325_06507| N326_12334| N327_11375| N328_02575| N329_10835| N330_07163| N331_03700| N332_07952| N333_09684| N334_00934| N335_14203| N336_09594| N339_10284| N340_07563| N341_04318| NSR2| nurse cell scavenger receptor 2| PANDA_011653| Scara4| scavenger receptor class A, member 4| scavenger receptor with C-type lectin| SRCL| UY3_11731| Y1Q_019587| Y956_04634| Z169_04924| zCL-P1| zeh0853| colec12

Policies

  • Terms of Service
  • Platform Consent
  • Privacy Policy
  • Disclaimer

About

  • Customer Support
  • Our Team
  • Affiliate Program

Navigation

  • Homepage
  • DNA Wellness Reports
  • Personalized Genetics Blog
  • Register your DNA Test Kit
  • Login
  • Careers
GET STARTED
  • SelfDecode is a personalized health report service, which enables users to obtain detailed information and reports based on their genome. SelfDecode does not treat, diagnose or cure any conditions, but is for informational and educational purposes alone.
SelfDecode © 2021 All Rights Reserved