The Function of COLEC12
Scavenger receptor that displays several functions associated with host defense. Promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast. Mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. Binds to several carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells. Binds also to sialyl Lewis X or a trisaccharide and asialo-orosomucoid (ASOR). May also play a role in the clearance of amyloid beta in Alzheimer disease.
Protein names
Recommended name:
Collectin-12Short name:
CL-P1Alternative name(s):
Collectin placenta protein 1hCL-P1
Nurse cell scavenger receptor 2
Scavenger receptor class A member 4
Scavenger receptor with C-type lectin
- RS621636 (COLEC12) ??
- RS644435 (COLEC12) ??
- RS7226677 (COLEC12) ??
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Top Gene-Substance Interactions
Substances That Increase COLEC12
| Substances | Interaction | Organism | Category |
Substances That Decrease COLEC12
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in perivascular macrophages. Expressed in plaques-surrounding reactive astrocytes and in perivascular astrocytes associated with cerebral amyloid angiopathy (CAA) in the temporal cortex of Alzheimer patient (at protein level). Strongly expressed in placenta. Moderately expressed in heart, skeletal muscle, small intestine and lung. Weakly expressed in brain, colon, thymus and kidney. Expressed in nurse-like cells. Expressed in reactive astrocytes and vascular/perivascular cells in the brain of Alzheimer patient.
Gene Pathways:
Molecular Function:
- Scavenger Receptor Activity
- Galactose Binding
- Signaling Pattern Recognition Receptor Activity
- Low-Density Lipoprotein Particle Binding
- Metal Ion Binding
Biological Processes:
- Receptor-Mediated Endocytosis
- Phagocytosis, Recognition
- Defense Response
- Carbohydrate Mediated Signaling
- Toll-Like Receptor 3 Signaling Pathway
- Innate Immune Response
- Protein Homooligomerization
- Positive Regulation Of Cell Adhesion Molecule Production
- Cellular Response To Exogenous Dsrna