The Function of COL16A1
Involved in mediating cell attachment and inducing integrin-mediated cellular reactions, such as cell spreading and alterations in cell morphology.
Protein names
Recommended name:
Collagen alpha-1Short name:
XVI- RS4568876 (COL16A1) ??
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Top Gene-Substance Interactions
Substances That Increase COL16A1
| Substances | Interaction | Organism | Category |
Substances That Decrease COL16A1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
In papillary dermis, is a component of specialized fibrillin-1-containing microfibrils, whereas in territorial cartilage matrix, it is localized to a discrete population of thin, weakly banded collagen fibrils in association with other collagens (at protein level). In the placenta, where it is found in the amnion, a membranous tissue lining the amniotic cavity. Within the amnion, it is found in an acellular, relatively dense layer of a complex network of reticular fibers. Also located to a fibroblast layer beneath this dense layer. Exists in tissues in association with other types of collagen.
Developmental stage:
Transiently elevated expression during gestation, and decrease at term.
Molecular Function:
Biological Processes:
- Cell Adhesion
- Cell Adhesion Mediated By Integrin
- Cellular Response To Amino Acid Stimulus
- Extracellular Matrix Organization
- Female Pregnancy
- Integrin Activation
- Integrin-Mediated Signaling Pathway
- Positive Regulation Of Focal Adhesion Assembly