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  3. CLP1

CLP1 (Cleavage and polyadenylation factor I subunit 1)

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The Function of CLP1

Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double-stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Plays a key role in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex: phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA (PubMed:24766809, PubMed:24766810). Its role in tRNA splicing and maturation is required for cerebellar development (PubMed:24766809, PubMed:24766810). Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex (RISC). However, endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by DICER1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing.

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Protein names

Recommended name:

Polyribonucleotide 5'-hydroxyl-kinase Clp1

Alternative name(s):

Polyadenylation factor Clp1
Polynucleotide kinase Clp1
Pre-mRNA cleavage complex II protein Clp1

Top Gene-Substance Interactions

Substances That Increase CLP1

Substances Interaction Organism Category

Substances That Decrease CLP1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • p53
  • STAT3
  • C/EBPbeta
  • FAC1
  • FOXF2
  • c-Myb
  • ATF6

Gene Pathways:

  • Gene Expression
  • mRNA surveillance pathway
  • Post-Elongation Processing of the Transcript
  • Transcription

Molecular Function:

  • Atp Binding
  • Atp-Dependent Polydeoxyribonucleotide 5'-Hydroxyl-Kinase Activity
  • Atp-Dependent Polyribonucleotide 5'-Hydroxyl-Kinase Activity
  • Polydeoxyribonucleotide Kinase Activity

Biological Processes:

  • Cerebellar Cortex Development
  • Mrna 3'-End Processing
  • Mrna Cleavage
  • Mrna Polyadenylation
  • Mrna Splicing, Via Spliceosome
  • Sirna Loading Onto Risc Involved In Rna Interference
  • Targeting Of Mrna For Destruction Involved In Rna Interference
  • Termination Of Rna Polymerase Ii Transcription
  • Trna Splicing, Via Endonucleolytic Cleavage And Ligation
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| AS27_13380| ATP/GTP-binding protein| CB1_000073017| CGI_10026601| Chitinase-3-like protein 2| CLP1, cleavage and polyadenylation factor I subunit| CLP1, cleavage and polyadenylation factor I subunit, homolog| D623_10004618| EGK_06218| fa28a12| GW7_13232| H920_16811| hClp1| Heab| homolog of yeast CFIA subunit Clp1p| MDA_GLEAN10006110| N302_08892| N303_01114| N305_12154| N306_02219| N307_14998| N308_13416| N325_10168| PAL_GLEAN10001698| PANDA_011756| Polyadenylation factor Clp1| polynucleotide kinase Clp1| polyribonucleotide 5-hydroxyl-kinase Clp1| polyribonucleotide 5'-hydroxyl-kinase Clp1| polyribonucleotide 5'-hydroxyl-kinase Clp1-like protein| Pre-mRNA cleavage complex II protein Clp1| protein CLP1 homolog| Protein CLP1-like protein| putative chitinase 1| RGD1307679| TREES_T100012503| UY3_15213| Y1Q_007276| Y956_14589| clp1

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