• Navigation
  • Register My DNA Kit
  • Features
  • Pricing
  • FAQ
  • About
  • Labs
  • Login
  • Get started
  1. Home
  2. Genes
  3. CLIC4

CLIC4 (Chloride intracellular channel 4)

Loading...

The Function of CLIC4

Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell-surface expression of HRH3. Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis).

0 users want this gene increased, 0 users want it decreased

Protein names

Recommended name:

Chloride intracellular channel protein 4

Alternative name(s):

Intracellular chloride ion channel protein p64H1

CLIC4 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS4601530 (CLIC4) ??

Top Gene-Substance Interactions

CLIC4 Interacts with These Diseases

Disease Score

Substances That Increase CLIC4

Substances Interaction Organism Category

Substances That Decrease CLIC4

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • p53
  • Hlf

Tissue specificity:

Detected in epithelial cells from colon, esophagus and kidney (at protein level). Expression is prominent in heart, kidney, placenta and skeletal muscle.

Induction:

Up-regulated by calcium ions in differentiating keratinocytes. Up-regulated in myofibroblasts.

Molecular Function:

  • Chloride Channel Activity
  • Voltage-Gated Ion Channel Activity

Biological Processes:

  • Angiogenesis
  • Apoptotic Process
  • Branching Morphogenesis Of An Epithelial Tube
  • Cell Differentiation
  • Cellular Response To Calcium Ion
  • Chloride Transport
  • Endothelial Cell Morphogenesis
  • Establishment Or Maintenance Of Apical/Basal Cell Polarity
  • Fertilization
  • Keratinocyte Differentiation
  • Multicellular Organism Growth
  • Negative Regulation Of Cell Migration
  • Regulation Of Cytoskeleton Organization
  • Retina Vasculature Morphogenesis In Camera-Type Eye
  • Vacuolar Acidification
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_14111| AS27_08913| AS28_08590| CB1_001244044| chloride intracellular channel 4 like| chloride intracellular channel 4 (mitochondrial)| Chloride intracellular channel protein 4| chloride intracellular channel protein 4-like protein| chloride intracellular channel protein 5| CLIC4L| D0Jmb3| D623_10029704| H1| H920_00893| huH1| I79_012085| intracellular chloride ion channel protein p64H1| M959_12805| mc3s5| mc3s5/mtCLIC| mitochondrial chloride intracellular channel 4| MTCLIC| N300_05866| N301_13619| N302_13928| N303_15085| N305_08390| N306_06241| N307_14706| N308_15308| N309_06500| N310_02474| N311_05953| N312_11586| N320_10038| N321_02778| N322_06014| N324_12967| N325_10921| N326_06549| N327_04324| N328_05755| N331_02089| N332_08211| N333_12408| N334_02901| N335_11662| N336_05321| N339_10483| N340_04228| N341_01583| p64H1| PAL_GLEAN10015140| PANDA_001119| TREES_T100021882| TU-74| xclic4| Y1Q_015314| Y956_14920| Z169_00211| clic4

Policies

  • Terms of Service
  • Platform Consent
  • Privacy Policy
  • Disclaimer

About

  • Customer Support
  • Our Team
  • Affiliate Program

Navigation

  • Homepage
  • DNA Wellness Reports
  • Personalized Genetics Blog
  • Register your DNA Test Kit
  • Login
  • Careers
GET STARTED
  • SelfDecode is a personalized health report service, which enables users to obtain detailed information and reports based on their genome. SelfDecode does not treat, diagnose or cure any conditions, but is for informational and educational purposes alone.
SelfDecode © 2021 All Rights Reserved