The Function of CLIC4
Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell-surface expression of HRH3. Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis).
Protein names
Recommended name:
Chloride intracellular channel protein 4Alternative name(s):
Intracellular chloride ion channel protein p64H1- RS4601530 (CLIC4) ??
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Top Gene-Substance Interactions
CLIC4 Interacts with These Diseases
| Disease | Score |
Substances That Increase CLIC4
| Substances | Interaction | Organism | Category |
Substances That Decrease CLIC4
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Detected in epithelial cells from colon, esophagus and kidney (at protein level). Expression is prominent in heart, kidney, placenta and skeletal muscle.
Induction:
Up-regulated by calcium ions in differentiating keratinocytes. Up-regulated in myofibroblasts.
Molecular Function:
Biological Processes:
- Angiogenesis
- Endothelial Cell Morphogenesis
- Chloride Transport
- Apoptotic Process
- Vacuolar Acidification
- Fertilization
- Cell Differentiation
- Keratinocyte Differentiation
- Negative Regulation Of Cell Migration
- Establishment Or Maintenance Of Apical/Basal Cell Polarity
- Multicellular Organism Growth
- Branching Morphogenesis Of An Epithelial Tube
- Regulation Of Cytoskeleton Organization
- Retina Vasculature Morphogenesis In Camera-Type Eye
- Cellular Response To Calcium Ion