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  3. CLIC1

CLIC1 (Chloride intracellular channel 1)

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The Function of CLIC1

Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of the cell cycle.

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Protein names

Recommended name:

Chloride intracellular channel protein 1

Short name:

NCC27

Alternative name(s):

Chloride channel ABP
Nuclear chloride ion channel 27
Regulatory nuclear chloride ion channel protein
hRNCC

CLIC1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS805304 (CLIC1) ??

Top Gene-Substance Interactions

CLIC1 Interacts with These Diseases

Disease Score

Substances That Increase CLIC1

Substances Interaction Organism Category

Substances That Decrease CLIC1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • p53

Tissue specificity:

Expression is prominent in heart, placenta, liver, kidney and pancreas.

Molecular Function:

  • Cadherin Binding Involved In Cell-Cell Adhesion
  • Chloride Channel Activity
  • Voltage-Gated Ion Channel Activity

Biological Processes:

  • Chloride Transport
  • Platelet Aggregation
  • Positive Regulation Of Osteoblast Differentiation
  • Regulation Of Cell Cycle
  • Regulation Of Mitochondrial Membrane Potential
  • Signal Transduction
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| Clcp| CB1_000383034| chloride channel ABP| chloride intracellular channel protein| chloride intracellular channel protein 1| D623_10007248| G6| H920_17557| hRNCC| M91_10770| MDA_GLEAN10005634| NCC27| nuclear chloride ion channel 27| nuclear chloride ion channel protein| p64CLCP| PANDA_020401| regulatory nuclear chloride ion channel protein| RNCC protein| TREES_T100017794| xclic1| Y1Q_013943| clic1

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