The Function of CLIC1
Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of the cell cycle.
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Protein names
Recommended name:
Chloride intracellular channel protein 1Short name:
NCC27Alternative name(s):
Chloride channel ABPNuclear chloride ion channel 27
Regulatory nuclear chloride ion channel protein
hRNCC
- RS805304 (CLIC1) ??
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Top Gene-Substance Interactions
CLIC1 Interacts with These Diseases
| Disease | Score |
Substances That Increase CLIC1
| Substances | Interaction | Organism | Category |
Substances That Decrease CLIC1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expression is prominent in heart, placenta, liver, kidney and pancreas.
Molecular Function:
- Voltage-Gated Ion Channel Activity
- Chloride Channel Activity
- Cadherin Binding Involved In Cell-Cell Adhesion
Biological Processes:
- Chloride Transport
- Signal Transduction
- Positive Regulation Of Osteoblast Differentiation
- Regulation Of Cell Cycle
- Regulation Of Mitochondrial Membrane Potential
- Platelet Aggregation