The Function of CLDN7
Plays a major role in tight junction-specific obliteration of the intercellular space.
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Protein names
Recommended name:
Claudin-7Short name:
CLDN-7- RS5415 (CLDN7) ??
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Top Gene-Substance Interactions
CLDN7 Interacts with These Diseases
| Disease | Score |
Substances That Increase CLDN7
| Substances | Interaction | Organism | Category |
Substances That Decrease CLDN7
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in kidney, lung and prostate. Isoform 1 seems to be predominant, except in some normal prostate samples, where isoform 2 is the major form. Down-regulated in breast cancers, including ductal carcinoma in situ (DCIS), lobular carcinoma in situ (LCIS) and invasive ductal carcinoma (IDC) (at protein level), as well as in several cancer cell lines. Loss of expression correlates with histological grade, occurring predominantly in high-grade lesions.
Gene Pathways:
Induction:
By androgens.
Molecular Function:
Biological Processes:
- Positive Regulation Of Defense Response To Virus By Host
- Negative Regulation Of Cell Adhesion
- Positive Regulation Of Cell Proliferation
- Calcium-Independent Cell-Cell Adhesion Via Plasma Membrane Cell-Adhesion Molecules
- Negative Regulation Of Protein Homooligomerization
- Negative Regulation Of Apoptotic Process
- Xenophagy
- Positive Regulation Of Cell Motility