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  3. CLDN7

CLDN7 (Claudin 7)

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The Function of CLDN7

Plays a major role in tight junction-specific obliteration of the intercellular space.

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Protein names

Recommended name:

Claudin-7

Short name:

CLDN-7

CLDN7 SNPs

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  1. RS5415 (CLDN7) ??

Top Gene-Substance Interactions

CLDN7 Interacts with These Diseases

Disease Score

Substances That Increase CLDN7

Substances Interaction Organism Category

Substances That Decrease CLDN7

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • p53
  • Egr-1
  • HNF-4alpha1
  • HNF-4alpha2
  • GATA-6

Tissue specificity:

Expressed in kidney, lung and prostate. Isoform 1 seems to be predominant, except in some normal prostate samples, where isoform 2 is the major form. Down-regulated in breast cancers, including ductal carcinoma in situ (DCIS), lobular carcinoma in situ (LCIS) and invasive ductal carcinoma (IDC) (at protein level), as well as in several cancer cell lines. Loss of expression correlates with histological grade, occurring predominantly in high-grade lesions.

Gene Pathways:

  • Hepatitis C
  • Cell-Cell communication
  • Leukocyte transendothelial migration
  • Tight junction
  • Cell adhesion molecules (CAMs)

Induction:

By androgens.

Molecular Function:

  • Identical Protein Binding
  • Structural Molecule Activity

Biological Processes:

  • Calcium-Independent Cell-Cell Adhesion Via Plasma Membrane Cell-Adhesion Molecules
  • Negative Regulation Of Apoptotic Process
  • Negative Regulation Of Cell Adhesion
  • Negative Regulation Of Protein Homooligomerization
  • Positive Regulation Of Cell Motility
  • Positive Regulation Of Cell Proliferation
  • Positive Regulation Of Defense Response To Virus By Host
  • Xenophagy
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| claudin-1| CB1_000230012| CEPTRL2| Claudin-7| CLDN-7| clostridium perfringens enterotoxin receptor-like 2| CPETRL2| GW7_13810| Hs.84359| MDA_GLEAN10018282| PAL_GLEAN10010164| PANDA_013845| TREES_T100004119| Y1Q_004262| cldn7

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