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  3. CHSY1

CHSY1 (Chondroitin sulfate synthase 1)

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Summary of CHSY1

This gene encodes a protein play critical roles in the biosynthesis of chondroitin sulfate, which is needed for cell proliferation and morphogenesis. It is associated with higher risk for colorectal cancer (R). 

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The Function of CHSY1

Has both beta-1,3-glucuronic acid and beta-1,4-N-acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. Involved in the negative control of osteogenesis likely through the modulation of NOTCH signaling.

Protein names

Recommended name:

Chondroitin sulfate synthase 1

Alternative name(s):

Chondroitin glucuronyltransferase 1
Chondroitin synthase 1
ChSy-1
Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase 1
N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase 1
N-acetylgalactosaminyltransferase 1

CHSY1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS12593811 (CHSY1) ??
  2. RS752092 (CHSY1) ??

Top Gene-Substance Interactions

Substances That Increase CHSY1

Substances Interaction Organism Category

Substances That Decrease CHSY1

Substances Interaction Organism Category

Advanced Summary

     From NCBI Gene: Temtamy preaxial brachydactyly syndromeFrom UniProt: Temtamy preaxial brachydactyly syndrome (TPBS): A syndrome characterized by multiple congenital anomalies, mental retardation, sensorineural deafness, talon cusps of upper central incisors, growth retardation, and bilateral symmetric digital anomalies mainly in the form of preaxial brachydactyly and hyperphalangism. [MIM:605282]

     From NCBI Gene: This gene encodes a member of the chondroitin N-acetylgalactosaminyltransferase family. These enzymes possess dual glucuronyltransferase and galactosaminyltransferase activity and play critical roles in the biosynthesis of chondroitin sulfate, a glycosaminoglycan involved in many biological processes including cell proliferation and morphogenesis. Decreased expression of this gene may play a role in colorectal cancer, and mutations in this gene are a cause of temtamy preaxial brachydactyly syndrome. [provided by RefSeq, Dec 2011] From UniProt: Has both beta-1,3-glucuronic acid and beta-1,4-N-acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. Involved in the negative control of osteogenesis likely through the modulation of NOTCH signaling.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • STAT5A
  • STAT5B
  • NF-1
  • Pax-2

Tissue specificity:

Ubiquitous, with the highest levels in placenta. Detected at low levels in brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, adrenal gland, mammary gland, stomach, small intestine, lung and peripheral blood leukocytes.

Gene Pathways:

  • Metabolic pathways
  • Metabolism
  • Disease
  • Glycosaminoglycan biosynthesis - chondroitin sulfate

Cofactor:

Divalent metal cations. Highest activities are measured with Co(2+), Mn(2+) and Cd(2+).

Molecular Function:

  • Glucuronosyl-N-Acetylgalactosaminyl-Proteoglycan 4-Beta-N-Acetylgalactosaminyltransferase Activity
  • Metal Ion Binding
  • N-Acetylgalactosaminyl-Proteoglycan 3-Beta-Glucuronosyltransferase Activity

Biological Processes:

  • Bone Morphogenesis
  • Chondrocyte Development
  • Chondroitin Sulfate Biosynthetic Process
  • Negative Regulation Of Ossification
  • Positive Regulation Of Smoothened Signaling Pathway
  • Proximal/Distal Pattern Formation
  • Response To Nutrient Levels
  • Sulfation
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| CSS1| A306_14209| AS27_12885| AS28_02074| carbohydrate (chondroitin) synthase 1| carbohydrate synthase 1| chondroitin glucuronyltransferase 1| chondroitin glucuronyltransferase II| chondroitin synthase 1| CHSY| ChSy-1| chys1| D623_10011766| glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase 1| H920_18100| I79_005479| M91_08320| M959_10272| MDA_GLEAN10019489| N300_08082| N301_04400| N302_05014| N303_05981| N306_03903| N307_12604| N308_02621| N309_01392| N311_09354| N312_08000| N320_12564| N321_07169| N322_02624| N324_02744| N325_01173| N326_09562| N328_10313| N329_08202| N330_00765| N331_00795| N332_10429| N333_08871| N334_03509| N335_04156| N336_08428| N339_00984| N340_12400| N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase 1| N-acetylgalactosaminyltransferase 1| N-acetylgalactosaminyltransferase II| PAL_GLEAN10007344| PANDA_011717| TPBS| TREES_T100003496| UY3_01071| Y1Q_004100| Y956_09696| Z169_07670| chsy1

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