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  3. CHST11

CHST11 (Carbohydrate sulfotransferase 11)

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The Function of CHST11

Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Can also sulfate Gal residues in desulfated dermatan sulfate. Preferentially sulfates in GlcA->GalNAc unit than in IdoA->GalNAc unit. Does not form 4, 6-di-O-sulfated GalNAc when chondroitin sulfate C is used as an acceptor.

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Protein names

Recommended name:

Carbohydrate sulfotransferase 11

Short name:

C4S-1

Alternative name(s):

Chondroitin 4-O-sulfotransferase 1
Chondroitin 4-sulfotransferase 1
C4ST-1
C4ST1

CHST11 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS11112046 (CHST11) ??
  2. RS12811699 (CHST11) ??

Top Gene-Substance Interactions

Substances That Increase CHST11

Substances Interaction Organism Category

Substances That Decrease CHST11

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • Max
  • c-Myc
  • IRF-1
  • GATA-1
  • GATA-2
  • GATA-3

Tissue specificity:

Widely expressed. Highly expressed in spleen, thymus, bone marrow, peripheral blood leukocytes, lymph node, heart, brain, lung and placenta.

Molecular Function:

  • Chondroitin 4-Sulfotransferase Activity
  • N-Acetylgalactosamine 4-O-Sulfotransferase Activity
  • N-Acetylgalactosamine 4-Sulfate 6-O-Sulfotransferase Activity

Biological Processes:

  • Carbohydrate Biosynthetic Process
  • Chondrocyte Development
  • Chondroitin Sulfate Biosynthetic Process
  • Developmental Growth
  • Embryonic Digit Morphogenesis
  • Embryonic Viscerocranium Morphogenesis
  • Negative Regulation Of Apoptotic Process
  • Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
  • Polysaccharide Localization
  • Post-Anal Tail Morphogenesis
  • Post-Embryonic Development
  • Regulation Of Cell Proliferation
  • Respiratory Gaseous Exchange
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_06446| AS27_12520| AS28_09180| C4s| C4S-1| C4ST| C4ST1| C4ST-1| carbohydrate (chondroitin 4) sulfotransferase 11| CB1_002313019| chondroitin 4| chondroitin 4-O-sulfotransferase 1| chondroitin 4-sulfotransferase 1| EGK_04131| H920_08301| HSA269537| IgH/CHST11 fusion| M91_11821| M959_14041| MDA_GLEAN10021917| N300_08633| N301_04609| N302_12629| N303_09354| N305_09338| N306_06416| N307_13928| N308_00475| N309_12336| N310_01768| N312_05968| N320_11735| N321_09215| N322_00826| N324_05326| N325_12823| N326_09764| N327_00251| N328_11167| N329_01367| N330_05931| N331_04661| N332_07175| N333_10571| N334_00587| N335_00790| N336_02975| N339_08146| N340_11378| N341_01896| PAL_GLEAN10015462| PANDA_003519| TREES_T100002547| UY3_12982| Y1Q_023025| Y956_15179| Z169_02786| zC4ST-1| chst11

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