The Function of CHST11
Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Can also sulfate Gal residues in desulfated dermatan sulfate. Preferentially sulfates in GlcA->GalNAc unit than in IdoA->GalNAc unit. Does not form 4, 6-di-O-sulfated GalNAc when chondroitin sulfate C is used as an acceptor.
Protein names
Recommended name:
Carbohydrate sulfotransferase 11Short name:
C4S-1Alternative name(s):
Chondroitin 4-O-sulfotransferase 1Chondroitin 4-sulfotransferase 1
C4ST-1
C4ST1
- RS11112046 (CHST11) ??
- RS12811699 (CHST11) ??
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Top Gene-Substance Interactions
Substances That Increase CHST11
| Substances | Interaction | Organism | Category |
Substances That Decrease CHST11
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Widely expressed. Highly expressed in spleen, thymus, bone marrow, peripheral blood leukocytes, lymph node, heart, brain, lung and placenta.
Molecular Function:
- N-Acetylgalactosamine 4-O-Sulfotransferase Activity
- Chondroitin 4-Sulfotransferase Activity
- N-Acetylgalactosamine 4-Sulfate 6-O-Sulfotransferase Activity
Biological Processes:
- Chondrocyte Development
- Respiratory Gaseous Exchange
- Post-Embryonic Development
- Carbohydrate Biosynthetic Process
- Chondroitin Sulfate Biosynthetic Process
- Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
- Post-Anal Tail Morphogenesis
- Regulation Of Cell Proliferation
- Embryonic Digit Morphogenesis
- Negative Regulation Of Apoptotic Process
- Developmental Growth
- Embryonic Viscerocranium Morphogenesis
- Polysaccharide Localization