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  3. CHRNB3

CHRNB3 (Cholinergic receptor nicotinic beta 3 subunit)

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Summary of CHRNB3

This gene encodes part of a nicotinic acetylcholine receptor (R). 

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The Function of CHRNB3

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

Protein names

Recommended name:

Neuronal acetylcholine receptor subunit beta-3

CHRNB3 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS4950 (CHRNB3) ??
  2. RS4952 (CHRNB3) ??
  3. RS4953 (CHRNB3) ??
  4. RS55828312 (CHRNB3) ??
  5. RS6474413 (CHRNB3) ??

Top Gene-Substance Interactions

Substances That Increase CHRNB3

Substances Interaction Organism Category

Substances That Decrease CHRNB3

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • ER-alpha
  • Meis-1
  • TGIF

Gene Pathways:

  • Neuroactive ligand-receptor interaction
  • Neuronal System

Molecular Function:

  • Acetylcholine-Activated Cation-Selective Channel Activity
  • Acetylcholine Binding
  • Channel Activity
  • Drug Binding
  • Ligand-Gated Ion Channel Activity

Biological Processes:

  • Neuromuscular Synaptic Transmission
  • Protein Heterooligomerization
  • Response To Nicotine
  • Signal Transduction
  • Synaptic Transmission, Cholinergic
  • Transport

Drug Bank:

  • Galantamine
  • Ethanol
  • Nicotine
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| NACHR| A306_15830| acetylcholine receptor, neuronal nicotinic, beta-3 subunit| acetylcholine receptor, nicotinic, beta 3 (neuronal)| Acrb3| Anapl_08697| AS27_05684| AS28_07079| CB1_001095052| cholinergic receptor neuronal nicotinic beta protein 3| cholinergic receptor, nicotinic beta 3| cholinergic receptor, nicotinic, beta 3 (neuronal)| cholinergic receptor, nicotinic, beta 3 (neuronal) isoform A| cholinergic receptor, nicotinic, beta 3 (neuronal) isoform B| cholinergic receptor, nicotinic, beta polypeptide 3| D623_10030540| EGK_18896| H920_02157| I79_003985| M91_02664| M959_03458| MDA_GLEAN10024883| N300_02286| N301_08741| N302_05731| N303_06574| N305_03385| N306_10063| N307_13868| N308_02350| N309_13779| N311_03551| N312_01928| N320_03810| N321_13793| N322_12533| N324_10224| N326_06808| N327_04287| N328_07315| N329_12633| N330_01749| N331_10422| N332_05591| N333_08191| N334_10399| N335_11250| N336_09947| N339_12392| N340_03003| N341_04240| neuronal acetylcholine receptor subunit alpha-2| neuronal acetylcholine receptor subunit beta-3| nicb3| nicotinic acetylcholine receptor beta 3 subunit| nicotinic acetylcholine receptor (nAChR) beta 3 subunit| nicotinic acetylcholine receptor subunit beta3| PAL_GLEAN10021531| PANDA_006854| TREES_T100019183| UY3_10119| Y1Q_025556| Y956_14308| Z169_13156| chrnb3

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