• Navigation
  • Register My DNA Kit
  • Features
  • Pricing
  • FAQ
  • About
  • Labs
  • Login
  • Get started
  1. Home
  2. Genes
  3. CHRNA7

CHRNA7 (Cholinergic receptor nicotinic alpha 7 subunit)

Loading...

Summary of CHRNA7

This gene encodes part of an acetylcholine receptor. It is associated with risk for schizophrenia (R). 

It's better to have this gene increased most of the time.
0 users want this gene increased, 0 users want it decreased

The Function of CHRNA7

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin.

Protein names

Recommended name:

Neuronal acetylcholine receptor subunit alpha-7

CHRNA7 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS2337980 (CHRNA7) ??
  2. RS6494223 (CHRNA7) ??

Top Gene-Substance Interactions

CHRNA7 Interacts with These Diseases

Disease Score

Substances That Increase CHRNA7

Substances Interaction Organism Category

Substances That Decrease CHRNA7

Substances Interaction Organism Category

Advanced Summary

     From NCBI Gene: 15q13.3 microdeletion syndrome

     From NCBI Gene: The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. The proposed structure for each subunit is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. The protein encoded by this gene forms a homo-oligomeric channel, displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha-bungarotoxin. Once this receptor binds acetylcholine, it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. This gene is located in a region identified as a major susceptibility locus for juvenile myoclonic epilepsy and a chromosomal location involved in the genetic transmission of schizophrenia. An evolutionarily recent partial duplication event in this region results in a hybrid containing sequence from this gene and a novel FAM7A gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012] From UniProt: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • PPAR-gamma1
  • Nkx2-5
  • C/EBPalpha
  • E4BP4
  • Nkx5-1

Gene Pathways:

  • Neuroactive ligand-receptor interaction
  • Calcium signaling pathway
  • Neuronal System

Molecular Function:

  • Acetylcholine-Activated Cation-Selective Channel Activity
  • Acetylcholine Binding
  • Acetylcholine-Gated Cation-Selective Channel Activity
  • Acetylcholine Receptor Activity
  • Beta-Amyloid Binding
  • Chloride Channel Regulator Activity
  • Ligand-Gated Ion Channel Activity
  • Protein Homodimerization Activity
  • Toxic Substance Binding

Biological Processes:

  • Activation Of Mapk Activity
  • Calcium Ion Transport
  • Cellular Calcium Ion Homeostasis
  • Cognition
  • Ion Transmembrane Transport
  • Ion Transport
  • Memory
  • Negative Regulation Of Tumor Necrosis Factor Production
  • Positive Regulation Of Angiogenesis
  • Positive Regulation Of Cell Proliferation
  • Response To Hypoxia
  • Response To Nicotine
  • Signal Transduction
  • Synaptic Transmission, Cholinergic

Drug Bank:

  • Aprobarbital
  • Butabarbital
  • Butethal
  • Methylphenobarbital
  • Butalbital
  • Cytisine
  • Ethanol
  • Galantamine
  • Heptabarbital
  • Hexobarbital
  • Pentobarbital
  • Phenobarbital
  • Primidone
  • Talbutal
  • Thiopental
  • Varenicline
  • Nicotine
  • Amobarbital
  • Dextromethorphan
  • Secobarbital
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_10882| a7 nicotinic acetylcholine receptor| acetylcholine receptor alpha 7 neural| Acra7| alpha7| alpha7-nAChR| alpha 7 neuronal nicotinic acetylcholine receptor| alpha 7 nicotinic acetylcholine receptor| alpha-7 nicotinic cholinergic receptor subunit| alpha7 nicotinic receptor| Anapl_06149| AS27_14904| AS28_04203| BTX| bungarotoxin alpha| CB1_060968001| cholinergic receptor alpha 7 variant 1| cholinergic receptor alpha 7 variant 2| cholinergic receptor alpha 7 variant 3| cholinergic receptor alpha 7 variant 4| cholinergic receptor alpha 7 variant 5| cholinergic receptor nicotinic alpha 7| cholinergic receptor, nicotinic alpha 7| cholinergic receptor, nicotinic, alpha 7| cholinergic receptor, nicotinic, alpha 7 (neuronal)| cholinergic receptor, nicotinic, alpha polypeptide 7| C holinergic receptor, nicotinic, alpha polypeptide 7 (neuronal nicotinic acetycholine receptor alpha 7) (bungarotoxin alpha)| CHRNA7-2| CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion| CHRNA7-FAM7A fusion| dZ70B1.1| GW7_09947| M959_05256| N300_11926| N301_08233| N303_08436| N305_08045| N306_09282| N307_06526| N308_02783| N309_06271| N310_09613| N312_09864| N321_07260| N324_00661| N325_11446| N327_11148| N329_04937| N332_08625| N333_12678| N335_13952| N340_06017| N341_12146| nAchR| nachra7| NARAD| neuronal acetylcholine receptor protein, alpha-7 chain| Neuronal acetylcholine receptor protein, alpha-7 subunit precursor-like protein| Neuronal acetylcholine receptor subunit alpha-7| neuronal acetylcholine receptor subunit alpha-7-like| neuronal acetylcholine receptor subunit alpha-7-like protein| neuronal nicotinic acetycholine receptor alpha 7| nica7| nicotinic acetylcholine receptor alpha7| nicotinic acetylcholine receptor subunit alpha7| nicotinic receptor alpha 7 subunit| PANDA_019353| Y1Q_020628| Y956_05553| Z169_06642| chrna7

Policies

  • Terms of Service
  • Platform Consent
  • Privacy Policy
  • Disclaimer

About

  • Customer Support
  • Our Team
  • Affiliate Program

Navigation

  • Homepage
  • DNA Wellness Reports
  • Personalized Genetics Blog
  • Register your DNA Test Kit
  • Login
  • Careers
GET STARTED
  • SelfDecode is a personalized health report service, which enables users to obtain detailed information and reports based on their genome. SelfDecode does not treat, diagnose or cure any conditions, but is for informational and educational purposes alone.
SelfDecode © 2021 All Rights Reserved