Summary of CHRNA7
This gene encodes part of an acetylcholine receptor. It is associated with risk for schizophrenia (R).
The Function of CHRNA7
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin.
Protein names
Recommended name:
Neuronal acetylcholine receptor subunit alpha-7- RS2337980 (CHRNA7) ??
- RS6494223 (CHRNA7) ??
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Top Gene-Substance Interactions
CHRNA7 Interacts with These Diseases
| Disease | Score |
Substances That Increase CHRNA7
| Substances | Interaction | Organism | Category |
Substances That Decrease CHRNA7
| Substances | Interaction | Organism | Category |
Advanced Summary
From NCBI Gene: 15q13.3 microdeletion syndrome
From NCBI Gene: The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. The proposed structure for each subunit is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. The protein encoded by this gene forms a homo-oligomeric channel, displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha-bungarotoxin. Once this receptor binds acetylcholine, it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. This gene is located in a region identified as a major susceptibility locus for juvenile myoclonic epilepsy and a chromosomal location involved in the genetic transmission of schizophrenia. An evolutionarily recent partial duplication event in this region results in a hybrid containing sequence from this gene and a novel FAM7A gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012] From UniProt: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin.
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Molecular Function:
- Acetylcholine-Activated Cation-Selective Channel Activity
- Acetylcholine Binding
- Acetylcholine-Gated Cation-Selective Channel Activity
- Acetylcholine Receptor Activity
- Beta-Amyloid Binding
- Chloride Channel Regulator Activity
- Ligand-Gated Ion Channel Activity
- Protein Homodimerization Activity
- Toxic Substance Binding
Biological Processes:
- Activation Of Mapk Activity
- Calcium Ion Transport
- Cellular Calcium Ion Homeostasis
- Cognition
- Ion Transmembrane Transport
- Ion Transport
- Memory
- Negative Regulation Of Tumor Necrosis Factor Production
- Positive Regulation Of Angiogenesis
- Positive Regulation Of Cell Proliferation
- Response To Hypoxia
- Response To Nicotine
- Signal Transduction
- Synaptic Transmission, Cholinergic
Drug Bank:
- Aprobarbital
- Butabarbital
- Butethal
- Methylphenobarbital
- Butalbital
- Cytisine
- Ethanol
- Galantamine
- Heptabarbital
- Hexobarbital
- Pentobarbital
- Phenobarbital
- Primidone
- Talbutal
- Thiopental
- Varenicline
- Nicotine
- Amobarbital
- Dextromethorphan
- Secobarbital