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  3. CHRNA3

CHRNA3 (Cholinergic receptor nicotinic alpha 3 subunit)

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Summary of CHRNA3

CHRNA3 (cholinergic receptor nicotinic alpha 3) encodes a protein in the nicotinic acetylcholine receptor family. 

It plays a role in neurotransmission.

Polymorphisms in this gene can lead to a higher risk of starting smoking and an increased susceptibility to lung cancer (R).

It's better to have this gene increased most of the time.
0 users want this gene increased, 0 users want it decreased

The Function of CHRNA3

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

Protein names

Recommended name:

Neuronal acetylcholine receptor subunit alpha-3

CHRNA3 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS1051730 (CHRNA3) ??
  2. RS114205691 (CHRNA3) ??
  3. RS12910984 (CHRNA3) ??
  4. RS12914385 (CHRNA3) ??
  5. RS1317286 (CHRNA3) ??
  6. RS3743078 (CHRNA3) ??
  7. RS55676755 (CHRNA3) ??
  8. RS578776 (CHRNA3) ??
  9. RS6495309 (CHRNA3) ??
  10. RS8040868 (CHRNA3) ??
  11. RS8042374 (CHRNA3) ??
  12. RS938682 (CHRNA3) ??

Top Gene-Substance Interactions

CHRNA3 Interacts with These Diseases

Disease Score

Substances That Increase CHRNA3

Substances Interaction Organism Category

Substances That Decrease CHRNA3

Substances Interaction Organism Category

Advanced Summary

CHRNA3 (cholinergic receptor nicotinic alpha 3) encodes a protein in the nicotinic acetylcholine receptor family. 

It plays a role in neurotransmission.

Polymorphisms in this gene can lead to a higher risk of starting smoking and an increased susceptibility to lung cancer (R).

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • CREB
  • c-Jun
  • deltaCREB
  • NF-kappaB1
  • XBP-1
  • NF-kappaB2

Gene Pathways:

  • Neuroactive ligand-receptor interaction
  • Neuronal System

Molecular Function:

  • Acetylcholine-Activated Cation-Selective Channel Activity
  • Acetylcholine Binding
  • Acetylcholine Receptor Activity
  • Ligand-Gated Ion Channel Activity
  • Drug Binding

Biological Processes:

  • Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity
  • Behavioral Response To Nicotine
  • Excitatory Postsynaptic Potential
  • Ion Transport
  • Locomotory Behavior
  • Nervous System Development
  • Regulation Of Acetylcholine Secretion, Neurotransmission
  • Regulation Of Dendrite Morphogenesis
  • Regulation Of Membrane Potential
  • Regulation Of Smooth Muscle Contraction
  • Signal Transduction
  • Synaptic Transmission, Cholinergic
  • Synaptic Transmission Involved In Micturition
  • Heart Development
  • Protein Heterooligomerization
  • Response To Inorganic Substance

Drug Bank:

  • Levomethadyl Acetate
  • Pentolinium
  • Bupropion
  • Cytisine
  • Dextromethorphan
  • Ethanol
  • Galantamine
  • Varenicline
  • Nicotine
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| (a)3| A306_02592| acetylcholine receptor alpha3| Acetylcholine receptor alpha 3 (neuronal nicotine)| Acra3| Acra-3| alpha 3| AS27_06166| AS28_07316| CB1_000113007| cetylcholine receptor alpha 3 (neuronal nicotine)| cholinergic receptor nicotinic alpha 3| cholinergic receptor, nicotinic alpha 3| cholinergic receptor, nicotinic, alpha 3| cholinergic receptor, nicotinic, alpha 3 (neuronal)| cholinergic receptor nicotinic alpha polypeptide 3| cholinergic receptor, nicotinic, alpha polypeptide 3| cholinergic receptor nicotinic alpha polypeptide 4| CHRNA3 protein-like| D623_10007157| H920_03295| LNCR2| M91_07665| M959_05209| MDA_GLEAN10005733| N300_12557| N301_08907| N302_08484| N303_01397| N305_01342| N306_15264| N307_11156| N309_07108| N310_07090| N311_00288| N312_01210| N320_06938| N321_00294| N322_10683| N325_12351| N326_06566| N328_08577| N329_11229| N331_05757| N332_11012| N333_07585| N334_09456| N335_12587| N336_10044| N339_00121| N340_06112| NACHRA3| Neuronal acetylcholine receptor subunit alpha-3| neuronal nicotinic acetylcholine receptor alpha 3 subunit| neuronal nicotinic acetylcholine receptor, alpha 3 subunit| neuronal nicotinic acetylcholine receptor, alpha3 subunit| neuronal nicotinic acetylcholine receptor subunit 3| nica3| nicotinic acetylcholine receptor subunit alpha3| PANDA_012138| PAOD2| Y1Q_016342| Y956_05504| chrna3

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