Summary of CHRNA3
CHRNA3 (cholinergic receptor nicotinic alpha 3) encodes a protein in the nicotinic acetylcholine receptor family.
It plays a role in neurotransmission.
Polymorphisms in this gene can lead to a higher risk of starting smoking and an increased susceptibility to lung cancer (R).
The Function of CHRNA3
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Protein names
Recommended name:
Neuronal acetylcholine receptor subunit alpha-3- RS1051730 (CHRNA3) ??
- RS114205691 (CHRNA3) ??
- RS12910984 (CHRNA3) ??
- RS12914385 (CHRNA3) ??
- RS1317286 (CHRNA3) ??
- RS3743078 (CHRNA3) ??
- RS55676755 (CHRNA3) ??
- RS578776 (CHRNA3) ??
- RS6495309 (CHRNA3) ??
- RS8040868 (CHRNA3) ??
- RS8042374 (CHRNA3) ??
- RS938682 (CHRNA3) ??
To see your genotype, you should be logged in and have a file with your genotype uploaded.
Top Gene-Substance Interactions
CHRNA3 Interacts with These Diseases
| Disease | Score |
Substances That Increase CHRNA3
| Substances | Interaction | Organism | Category |
Substances That Decrease CHRNA3
| Substances | Interaction | Organism | Category |
Advanced Summary
CHRNA3 (cholinergic receptor nicotinic alpha 3) encodes a protein in the nicotinic acetylcholine receptor family.
It plays a role in neurotransmission.
Polymorphisms in this gene can lead to a higher risk of starting smoking and an increased susceptibility to lung cancer (R).
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
- Acetylcholine-Activated Cation-Selective Channel Activity
- Acetylcholine Binding
- Acetylcholine Receptor Activity
- Ligand-Gated Ion Channel Activity
- Drug Binding
Biological Processes:
- Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity
- Behavioral Response To Nicotine
- Excitatory Postsynaptic Potential
- Ion Transport
- Locomotory Behavior
- Nervous System Development
- Regulation Of Acetylcholine Secretion, Neurotransmission
- Regulation Of Dendrite Morphogenesis
- Regulation Of Membrane Potential
- Regulation Of Smooth Muscle Contraction
- Signal Transduction
- Synaptic Transmission, Cholinergic
- Synaptic Transmission Involved In Micturition
- Heart Development
- Protein Heterooligomerization
- Response To Inorganic Substance
Drug Bank:
- Levomethadyl Acetate
- Pentolinium
- Bupropion
- Cytisine
- Dextromethorphan
- Ethanol
- Galantamine
- Varenicline
- Nicotine