Summary of CHRNA3
CHRNA3 (cholinergic receptor nicotinic alpha 3) encodes a protein in the nicotinic acetylcholine receptor family.
It plays a role in neurotransmission.
Polymorphisms in this gene can lead to a higher risk of starting smoking and an increased susceptibility to lung cancer (R).
The Function of CHRNA3
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Protein names
Recommended name:
Neuronal acetylcholine receptor subunit alpha-3- RS1051730 (CHRNA3) ??
- RS114205691 (CHRNA3) ??
- RS12910984 (CHRNA3) ??
- RS12914385 (CHRNA3) ??
- RS1317286 (CHRNA3) ??
- RS3743078 (CHRNA3) ??
- RS55676755 (CHRNA3) ??
- RS578776 (CHRNA3) ??
- RS6495309 (CHRNA3) ??
- RS8040868 (CHRNA3) ??
- RS8042374 (CHRNA3) ??
- RS938682 (CHRNA3) ??
To see your genotype, you should be logged in and have a file with your genotype uploaded.
Top Gene-Substance Interactions
CHRNA3 Interacts with These Diseases
| Disease | Score |
Substances That Increase CHRNA3
| Substances | Interaction | Organism | Category |
Substances That Decrease CHRNA3
| Substances | Interaction | Organism | Category |
Advanced Summary
CHRNA3 (cholinergic receptor nicotinic alpha 3) encodes a protein in the nicotinic acetylcholine receptor family.
It plays a role in neurotransmission.
Polymorphisms in this gene can lead to a higher risk of starting smoking and an increased susceptibility to lung cancer (R).
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
- Drug Binding
- Ligand-Gated Ion Channel Activity
- Acetylcholine Receptor Activity
- Acetylcholine Binding
- Acetylcholine-Activated Cation-Selective Channel Activity
Biological Processes:
- Ion Transport
- Regulation Of Smooth Muscle Contraction
- Signal Transduction
- Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity
- Synaptic Transmission, Cholinergic
- Nervous System Development
- Heart Development
- Locomotory Behavior
- Response To Inorganic Substance
- Regulation Of Acetylcholine Secretion, Neurotransmission
- Behavioral Response To Nicotine
- Regulation Of Membrane Potential
- Regulation Of Dendrite Morphogenesis
- Protein Heterooligomerization
- Excitatory Postsynaptic Potential
- Synaptic Transmission Involved In Micturition
Drug Bank:
- Levomethadyl Acetate
- Pentolinium
- Bupropion
- Cytisine
- Dextromethorphan
- Ethanol
- Galantamine
- Varenicline
- Nicotine