Summary of CHRM2

CHRM2 (cholinergic receptor muscarinic 2) can induce lower heart rate and lower body temperature by activation with acetylcholine. It plays an important role in heart rate, contractile responses in the bladder, and inhibits the growth of brain tumor cells. However, it is associated with alcohol and drug abuse, nicotine addiction, bipolar disorder, depression, and psychosis. 

One study suggests that increasing levels of CHRM2 may be involved in the mechanisms of action of mood stabilisers and tricyclic antidepressants (R).

CHRM2 cholinergic receptor muscarinic 2

  • Induces low heart rate, low body temperature and shakiness by activation with acetylcholine [R].

  • Also found in the colon [R] and higher production in the urethra [R].

  • associated with contractile response in the bladder [R] and in the bladder of patients with brain-caused bladder dysfunction [R].

  • Associated with the level of response to alcohol [R].

  • An important role in heart rate [R].

  • Associated with bipolar disorder [R].

  • Increased expression in white blood cells from asthmatic children [R].

  • Increases cell division in muscle cells obtained from elderly patients [R].

  • Inhibits the growth of brain tumor cells [R].

  • Associated with externalizing behavior [R].

  • Associated with alcohol dependence [R] and drug abuse [R][R].

  • Associated with nicotine addiction [R].

  • Slightly lower response to asthma treatment [R].

  • Associated with heritable heart muscle disease (mutation Cys173Trp) [R].

  • Higher production in some stages of Achilles tendon inflammation [R].

  • Associated with  personality traits such as agreeableness and conscientiousness.[R]

  • Associated with IQ [R].

  • Decreased production of CHRM2 increases production of Alzheimer disease related proteins [R].

  • Associated with major depression in women [R].

  • Associated with psychosis in patients with Alzheimer’s disease [R].

CHRM2 is a protein coding gene [R1] that is associated with genetic diseases such as bladder neck obstruction and a rare disorder in which a pregnant woman’s heart becomes weakened and enlarged (Peripartum cardiomyopathy) [R1]. This disorder becomes more common after the age of thirty and risk factors include obesity, smoking, and poor nourishment. However, a major risk factor is being of African-American descent, since it is a genetic disease. It is possible to minimize your chances of getting this disease if you maintain a healthy lifestyle and limit smoking and alcohol [R2]. The receptors coded by this gene also influence the nervous system [R3].

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The Function of CHRM2

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol.

Protein names

Recommended name:

Muscarinic acetylcholine receptor M2

Top Gene-Substance Interactions

CHRM2 Interacts with These Diseases

Substances That Increase CHRM2

Substances That Decrease CHRM2

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity

Technical