Summary of CHRM2
The CHRM2 gene codes for cholinergic receptor muscarinic 2 (CHRM2) [R].
Muscarinic receptors can be activated by muscarine (a compound found in some mushrooms) and acetylcholine (a chemical messenger of the nervous system) [R].
When activated, CHRM2 prevents acetylcholine release. It can [R, R]:
- Lower heart rate
- Promote urination
- Constrict airways
CHRM2 polymorphisms have been linked to [R, R, R, R]:
- Intelligence
- COPD severity
- Asthma
- Depression
It's better to have this gene increased
most of the time.
0 users want this gene increased,
0 users want it decreased
Protein names
Recommended name:
Muscarinic acetylcholine receptor M2- RS1364402 (CHRM2) ??
- RS1455858 (CHRM2) ??
- RS1824024 (CHRM2) ??
- RS2061174 (CHRM2) ??
- RS2350782 (CHRM2) ??
- RS324640 (CHRM2) ??
- RS324650 (CHRM2) ??
- RS8191992 (CHRM2) ??
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Top Gene-Substance Interactions
CHRM2 Interacts with These Diseases
| Disease | Score |
Substances That Increase CHRM2
| Substances | Interaction | Organism | Category |
Substances That Decrease CHRM2
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Gene Pathways:
Induction:
Up-regulated in response to enterovirus 71 (EV71) infection.
Molecular Function:
Biological Processes:
- Regulation Of Smooth Muscle Contraction
- G-Protein Coupled Receptor Signaling Pathway
- G-Protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
- Adenylate Cyclase-Modulating G-Protein Coupled Receptor Signaling Pathway
- Adenylate Cyclase-Inhibiting G-Protein Coupled Acetylcholine Receptor Signaling Pathway
- Phospholipase C-Activating G-Protein Coupled Acetylcholine Receptor Signaling Pathway
- G-Protein Coupled Acetylcholine Receptor Signaling Pathway
- Synaptic Transmission, Cholinergic
- Nervous System Development
- Regulation Of Heart Contraction
- Response To Virus
Drug Bank:
- Aclidinium
- Anisotropine Methylbromide
- Cryptenamine
- Dimetindene
- Doxacurium Chloride
- Ethopropazine
- Amitriptyline
- Amoxapine
- Aripiprazole
- Atropine
- Bethanechol
- Carbachol
- Chlorprothixene
- Cinnarizine
- Clozapine
- Cocaine
- Cyproheptadine
- Darifenacin
- Dicyclomine
- Diphenidol
- Disopyramide
- Doxepin
- Fesoterodine
- Flavoxate
- Glycopyrrolate
- Homatropine Methylbromide
- Hyoscyamine
- Imipramine
- Ipratropium Bromide
- Methylscopolamine Bromide
- Metixene
- Pethidine
- Scopolamine
- Solifenacin
- Tiotropium
- Tolterodine
- Umeclidinium
- Maprotiline
- Methotrimeprazine
- Metocurine
- Mivacurium
- Nortriptyline
- Olanzapine
- Oxybutynin
- Oxyphencyclimine
- Pancuronium
- Pilocarpine
- Pipecuronium
- Procyclidine
- Promazine
- Promethazine
- Propiomazine
- Rocuronium
- Succinylcholine
- Triflupromazine
- Trihexyphenidyl
- Trimipramine
- Tropicamide
- Ziprasidone
- Brompheniramine
- Desipramine
- Gallamine Triethiodide
- Ketamine
- Loxapine
- Nicardipine
- Paroxetine
- Quetiapine