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CHIA (Chitinase, acidic)

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Summary of CHIA

This gene encodes a protein that degrades chitin. It is associated with higher susceptibility to asthma (R). 

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The Function of CHIA

Degrades chitin and chitotriose. May participate in the defense against nematodes, fungi and other pathogens. Plays a role in T-helper cell type 2 (Th2) immune response. Contributes to the response to IL-13 and inflammation in response to IL-13. Stimulates chemokine production by pulmonary epithelial cells. Protects lung epithelial cells against apoptosis and promotes phosphorylation of AKT1. Its function in the inflammatory response and in protecting cells against apoptosis is inhibited by allosamidin, suggesting that the function of this protein depends on carbohydrate binding.

Protein names

Recommended name:

Acidic mammalian chitinase

Alternative name(s):

AMCase
Lung-specific protein TSA1902

CHIA SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS3818822 (CHIA) ??
  2. RS7411387 (CHIA) ??

Top Gene-Substance Interactions

Substances That Increase CHIA

Substances Interaction Organism Category

Substances That Decrease CHIA

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • AhR
  • Max
  • Arnt
  • Pax-6
  • C/EBPalpha
  • c-Myc
  • TBP
  • TFIID
  • Ik-1

Tissue specificity:

Detected in lung epithelial cells from asthma patients (at protein level). Highly expressed in stomach. Detected at lower levels in lung.

Gene Pathways:

  • Amino sugar and nucleotide sugar metabolism

Induction:

Up-regulated in lung epithelial cells from asthma patients.

Molecular Function:

  • Carbohydrate Binding
  • Chitinase Activity
  • Chitin Binding
  • Kinase Binding
  • Lysozyme Activity

Biological Processes:

  • Apoptotic Process
  • Carbohydrate Metabolic Process
  • Cell Wall Chitin Metabolic Process
  • Chitin Catabolic Process
  • Chitin Metabolic Process
  • Digestion
  • Immune Response
  • Polysaccharide Catabolic Process
  • Positive Regulation Of Chemokine Secretion
  • Production Of Molecular Mediator Involved In Inflammatory Response
  • Response To Fungus
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| eosinophil chemotactic cytokine| acidic mammalian chitinase| AMCASE| CBPb04| CBPCH04| chia1| CHIT2| chitinase-3-like protein 2| chitin-binding protein b04| D623_10030028| lung-specific protein TSA1902| N309_05985| N312_10429| N320_08788| N321_00981| N322_04033| N326_09696| N327_13432| N328_08821| N333_04979| N334_07797| N335_09747| N336_08785| N340_08837| N341_05710| PAL_GLEAN10017390| small acid mammalian chitinase| TSA1902| chia

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