Summary of CHIA
This gene encodes a protein that degrades chitin. It is associated with higher susceptibility to asthma (R).
The Function of CHIA
Degrades chitin and chitotriose. May participate in the defense against nematodes, fungi and other pathogens. Plays a role in T-helper cell type 2 (Th2) immune response. Contributes to the response to IL-13 and inflammation in response to IL-13. Stimulates chemokine production by pulmonary epithelial cells. Protects lung epithelial cells against apoptosis and promotes phosphorylation of AKT1. Its function in the inflammatory response and in protecting cells against apoptosis is inhibited by allosamidin, suggesting that the function of this protein depends on carbohydrate binding.
Protein names
Recommended name:
Acidic mammalian chitinaseAlternative name(s):
AMCaseLung-specific protein TSA1902
- RS3818822 (CHIA) ??
- RS7411387 (CHIA) ??
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Top Gene-Substance Interactions
Substances That Increase CHIA
| Substances | Interaction | Organism | Category |
Substances That Decrease CHIA
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Detected in lung epithelial cells from asthma patients (at protein level). Highly expressed in stomach. Detected at lower levels in lung.
Gene Pathways:
Induction:
Up-regulated in lung epithelial cells from asthma patients.
Molecular Function:
Biological Processes:
- Polysaccharide Catabolic Process
- Production Of Molecular Mediator Involved In Inflammatory Response
- Carbohydrate Metabolic Process
- Chitin Metabolic Process
- Chitin Catabolic Process
- Cell Wall Chitin Metabolic Process
- Apoptotic Process
- Immune Response
- Digestion
- Response To Fungus
- Positive Regulation Of Chemokine Secretion