Disease	Score

Substances	Interaction	Organism	Category

Substances	Interaction	Organism	Category

     From NCBI Gene: ASTHMA-RELATED TRAITS, SUSCEPTIBILITY TO, 7SchizophreniaFrom UniProt: Asthma-related traits 7 (ASRT7): Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, dyspnea, bronchial hyperresponsiveness as assessed by methacholine challenge test, serum IgE levels, atopy and atopic dermatitis. [MIM:611960]

     From NCBI Gene: Chitinases catalyze the hydrolysis of chitin, which is an abundant glycopolymer found in insect exoskeletons and fungal cell walls. The glycoside hydrolase 18 family of chitinases includes eight human family members. This gene encodes a glycoprotein member of the glycosyl hydrolase 18 family. The protein lacks chitinase activity and is secreted by activated macrophages, chondrocytes, neutrophils and synovial cells. The protein is thought to play a role in the process of inflammation and tissue remodeling. [provided by RefSeq, Sep 2009] From UniProt: Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung.

Condition	Change (log2fold)	Comparison	Species	Experimental variables	Experiment name

Condition	Change (log2fold)	Comparison	Species	Experimental variables	Experiment name

The following transcription factors affect gene expression:

• AP-1
• c-Jun
• Sox9

Tissue specificity:

Present in activated macrophages, articular chondrocytes, synovial cells as well as in liver. Very low or undetectable expression in non-inflammatory colon. Undetectable in muscle tissues, lung, pancreas, mononuclear cells, or fibroblasts.

Induction:

Up-regulated in colon under several inflammatory conditions. Down-regulated by hyperoxia in bronchial epithelial cells.

Caution:

Although it belongs to the glycosyl hydrolase 18 family, Leu-140 is present instead of the conserved Glu which is an active site residue. Therefore this protein lacks chitinase activity.

Molecular Function:

• Hydrolase Activity, Hydrolyzing O-Glycosyl Compounds
• Extracellular Matrix Structural Constituent
• Chitin Binding
• Carbohydrate Binding

Biological Processes:

• Carbohydrate Metabolic Process
• Apoptotic Process
• Inflammatory Response
• Activation Of Nf-Kappab-Inducing Kinase Activity
• Response To Mechanical Stimulus
• Positive Regulation Of Peptidyl-Threonine Phosphorylation
• Lung Development
• Response To Tumor Necrosis Factor
• Positive Regulation Of Angiogenesis
• Cartilage Development
• Positive Regulation Of Protein Kinase B Signaling
• Positive Regulation Of Erk1 And Erk2 Cascade
• Response To Interleukin-1
• Response To Interleukin-6
• Cellular Response To Interleukin-1
• Cellular Response To Tumor Necrosis Factor
• Interleukin-8 Secretion

*synonyms