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  3. CHFR

CHFR (Checkpoint with forkhead and ring finger domains)

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Summary of CHFR

This gene encodes a protein that plays an important role in the cell cyle. It is associated with higher risk for tumors (R). 

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The Function of CHFR

E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus. Probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the 'Lys-48'-linked ubiquitination of target proteins, leading to their degradation by the proteasome. Promotes the ubiquitination and subsequent degradation of AURKA and PLK1. Probably acts as a tumor suppressor, possibly by mediating the polyubiquitination of HDAC1, leading to its degradation. May also promote the formation of 'Lys-63'-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating UBC13-MMS2 (UBE2N-UBE2V2) heterodimer. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation, but are rather involved in signaling cellular stress.

Protein names

Recommended name:

E3 ubiquitin-protein ligase CHFR

Alternative name(s):

Checkpoint with forkhead and RING finger domains protein
RING finger protein 196

CHFR SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS2306536 (CHFR) ??
  2. RS2306541 (CHFR) ??
  3. RS3741489 (CHFR) ??

Top Gene-Substance Interactions

CHFR Interacts with These Diseases

Disease Score

Substances That Increase CHFR

Substances Interaction Organism Category

Substances That Decrease CHFR

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • CUTL1
  • GR
  • GR-alpha
  • NF-YB
  • NF-YC

Tissue specificity:

Ubiquitous.

Developmental stage:

Weakly expressed in G1 phase, and highly expressed during S phase.

Molecular Function:

  • Ligase Activity
  • Nucleotide Binding
  • Ubiquitin Protein Ligase Activity
  • Ubiquitin-Protein Transferase Activity
  • Zinc Ion Binding

Biological Processes:

  • Cell Division
  • Mitotic Cell Cycle Checkpoint
  • Mitotic Nuclear Division
  • Modification-Dependent Protein Catabolic Process
  • Positive Regulation Of Proteasomal Ubiquitin-Dependent Protein Catabolic Process
  • Positive Regulation Of Protein Ubiquitination
  • Protein Destabilization
  • Protein Polyubiquitination
  • Ubiquitin-Dependent Protein Catabolic Process
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| AS27_14406| C230082M18| CB1_000182014| checkpoint protein with forkhead and ring finger domains, E3 ubiquitin protein ligase| checkpoint with forkhead and ring finger domains, E3 ubiquitin p| checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase| Checkpoint with forkhead and RING finger domains protein| D623_10005223| e3 ubiquitin-protein ligase CHFR| fc43f10| H920_15031| I79_008145| MDA_GLEAN10012847| N300_08202| N302_01435| N308_04234| N309_13180| N312_05115| N322_02431| N324_04731| N325_07948| N330_03666| N340_01448| PAL_GLEAN10008689| PANDA_012324| RING finger protein 196| RNF116| RNF196| TREES_T100020488| UY3_02457| Y1Q_012673| Zinc finger protein 605| chfr

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