Summary of CHFR
This gene encodes a protein that plays an important role in the cell cyle. It is associated with higher risk for tumors (R).
The Function of CHFR
E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus. Probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the 'Lys-48'-linked ubiquitination of target proteins, leading to their degradation by the proteasome. Promotes the ubiquitination and subsequent degradation of AURKA and PLK1. Probably acts as a tumor suppressor, possibly by mediating the polyubiquitination of HDAC1, leading to its degradation. May also promote the formation of 'Lys-63'-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating UBC13-MMS2 (UBE2N-UBE2V2) heterodimer. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation, but are rather involved in signaling cellular stress.
Protein names
Recommended name:
E3 ubiquitin-protein ligase CHFRAlternative name(s):
Checkpoint with forkhead and RING finger domains proteinRING finger protein 196
- RS2306536 (CHFR) ??
- RS2306541 (CHFR) ??
- RS3741489 (CHFR) ??
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Top Gene-Substance Interactions
CHFR Interacts with These Diseases
| Disease | Score |
Substances That Increase CHFR
| Substances | Interaction | Organism | Category |
Substances That Decrease CHFR
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Ubiquitous.
Developmental stage:
Weakly expressed in G1 phase, and highly expressed during S phase.
Molecular Function:
- Nucleotide Binding
- Ubiquitin-Protein Transferase Activity
- Zinc Ion Binding
- Ligase Activity
- Ubiquitin Protein Ligase Activity
Biological Processes:
- Protein Polyubiquitination
- Ubiquitin-Dependent Protein Catabolic Process
- Mitotic Nuclear Division
- Mitotic Cell Cycle Checkpoint
- Modification-Dependent Protein Catabolic Process
- Positive Regulation Of Protein Ubiquitination
- Protein Destabilization
- Positive Regulation Of Proteasomal Ubiquitin-Dependent Protein Catabolic Process
- Cell Division