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  3. CFL1

CFL1 (Cofilin 1)

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The Function of CFL1

Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (PubMed:11812157, PubMed:15580268, PubMed:21834987, PubMed:23633677). Required for neural tube morphogenesis and neural crest cell migration.

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Protein names

Recommended name:

Cofilin-1

Alternative name(s):

18 kDa phosphoprotein
p18
Cofilin, non-muscle isoform

Top Gene-Substance Interactions

CFL1 Interacts with These Diseases

Disease Score

Substances That Increase CFL1

Substances Interaction Organism Category

Substances That Decrease CFL1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • AP-1
  • c-Jun
  • ARP-1
  • c-Myc

Tissue specificity:

Widely distributed in various tissues.

Gene Pathways:

  • Immune System
  • Regulation of actin cytoskeleton
  • Hemostasis
  • Axon guidance

Induction:

Up-regulated in response to enterovirus 71 (EV71) infection (at protein level).

Molecular Function:

  • Actin Filament Binding
  • Phosphatidylinositol Bisphosphate Binding

Biological Processes:

  • Actin Cytoskeleton Organization
  • Actin Filament Depolymerization
  • Cell Projection Organization
  • Cytoskeleton Organization
  • Negative Regulation Of Apoptotic Process
  • Negative Regulation Of Cell Size
  • Positive Regulation By Host Of Viral Process
  • Protein Import Into Nucleus
  • Regulation Of Cell Morphogenesis
  • Regulation Of Dendritic Spine Morphogenesis
  • Response To Virus
  • Rho Protein Signal Transduction
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| p18| 18 kDa phosphoprotein| ADF/cofilin| CB1_000429050| CFL| cfl1-a| cfl1-b| CFL2| cfl2l| Cof| cofilin| cofilin-1| cofilin-1-like protein| cofilin 1 (non-muscle)| cofilin 1, non-muscle| cofilin 2, like| cofilin, non-muscle isoform| epididymis secretory protein Li 15| H920_10257| HEL-S-15| M91_15924| MDA_GLEAN10017890| muscle cofilin 2| n-cofilin| PAL_GLEAN10011359| PANDA_004783| TREES_T100019331| UY3_03601| xac1| xac2| cfl1

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