The Function of CFL1
Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (PubMed:11812157, PubMed:15580268, PubMed:21834987, PubMed:23633677). Required for neural tube morphogenesis and neural crest cell migration.
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Protein names
Recommended name:
Cofilin-1Alternative name(s):
18 kDa phosphoproteinp18
Cofilin, non-muscle isoform
Top Gene-Substance Interactions
CFL1 Interacts with These Diseases
| Disease | Score |
Substances That Increase CFL1
| Substances | Interaction | Organism | Category |
Substances That Decrease CFL1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Widely distributed in various tissues.
Gene Pathways:
Induction:
Up-regulated in response to enterovirus 71 (EV71) infection (at protein level).
Molecular Function:
Biological Processes:
- Actin Cytoskeleton Organization
- Actin Filament Depolymerization
- Cell Projection Organization
- Cytoskeleton Organization
- Negative Regulation Of Apoptotic Process
- Negative Regulation Of Cell Size
- Positive Regulation By Host Of Viral Process
- Protein Import Into Nucleus
- Regulation Of Cell Morphogenesis
- Regulation Of Dendritic Spine Morphogenesis
- Response To Virus
- Rho Protein Signal Transduction