The Function of CES1
Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl-CoA ester. Hydrolyzes the methyl ester group of cocaine to form benzoylecgonine. Catalyzes the transesterification of cocaine to form cocaethylene. Displays fatty acid ethyl ester synthase activity, catalyzing the ethyl esterification of oleic acid to ethyloleate.
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Protein names
Recommended name:
Liver carboxylesterase 1Short name:
REHAlternative name(s):
Acyl-coenzyme A:cholesterol acyltransferaseACAT
Brain carboxylesterase hBr1
Carboxylesterase 1
CE-1
hCE-1
Cocaine carboxylesterase
Egasyn
HMSE
Methylumbelliferyl-acetate deacetylase 1
Monocyte/macrophage serine esterase
Retinyl ester hydrolase
Serine esterase 1
Triacylglycerol hydrolase
TGH
- RS2244613 (CES1) ??
- RS7184362 (CES1) ??
- RS8192935 (CES1) ??
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Top Gene-Substance Interactions
CES1 Interacts with These Diseases
| Disease | Score |
Substances That Increase CES1
| Substances | Interaction | Organism | Category |
Substances That Decrease CES1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed predominantly in liver with lower levels in heart and lung.
Gene Pathways:
Enzyme Regulation:
Activated by CHAPS.
Molecular Function:
- Carboxylic Ester Hydrolase Activity
- Methylumbelliferyl-Acetate Deacetylase Activity
- Sterol Esterase Activity
Biological Processes:
- Cholesterol Biosynthetic Process
- Cholesterol Ester Hydrolysis Involved In Cholesterol Transport
- Epithelial Cell Differentiation
- Medium-Chain Fatty Acid Metabolic Process
- Metabolic Process
- Response To Toxic Substance
- Xenobiotic Metabolic Process
Drug Bank:
- Dabigatran Etexilate
- L-Carnitine
- Capecitabine
- Cholic Acid
- Clopidogrel
- Cyclandelate
- Indomethacin
- Irinotecan
- Oseltamivir
- Probucol
- Rufinamide
- Selexipag
- Tamoxifen
- Trandolapril
- Ciclesonide
- Mycophenolate Mofetil
- Benzocaine