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  3. CES1

CES1 (Carboxylesterase 1)

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The Function of CES1

Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl-CoA ester. Hydrolyzes the methyl ester group of cocaine to form benzoylecgonine. Catalyzes the transesterification of cocaine to form cocaethylene. Displays fatty acid ethyl ester synthase activity, catalyzing the ethyl esterification of oleic acid to ethyloleate.

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Protein names

Recommended name:

Liver carboxylesterase 1

Short name:

REH

Alternative name(s):

Acyl-coenzyme A:cholesterol acyltransferase
ACAT
Brain carboxylesterase hBr1
Carboxylesterase 1
CE-1
hCE-1
Cocaine carboxylesterase
Egasyn
HMSE
Methylumbelliferyl-acetate deacetylase 1
Monocyte/macrophage serine esterase
Retinyl ester hydrolase
Serine esterase 1
Triacylglycerol hydrolase
TGH

CES1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS2244613 (CES1) ??
  2. RS7184362 (CES1) ??
  3. RS8192935 (CES1) ??

Top Gene-Substance Interactions

CES1 Interacts with These Diseases

Disease Score

Substances That Increase CES1

Substances Interaction Organism Category

Substances That Decrease CES1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • PPAR-gamma1
  • PPAR-gamma2
  • CREB
  • AP-1
  • c-Jun
  • PPAR-alpha
  • C/EBPalpha
  • TBP
  • TFIID
  • GATA-3

Tissue specificity:

Expressed predominantly in liver with lower levels in heart and lung.

Gene Pathways:

  • Metabolic pathways
  • Drug metabolism - other enzymes

Enzyme Regulation:

Activated by CHAPS.

Molecular Function:

  • Carboxylic Ester Hydrolase Activity
  • Methylumbelliferyl-Acetate Deacetylase Activity
  • Sterol Esterase Activity

Biological Processes:

  • Cholesterol Biosynthetic Process
  • Cholesterol Ester Hydrolysis Involved In Cholesterol Transport
  • Epithelial Cell Differentiation
  • Medium-Chain Fatty Acid Metabolic Process
  • Metabolic Process
  • Response To Toxic Substance
  • Xenobiotic Metabolic Process

Drug Bank:

  • Dabigatran Etexilate
  • L-Carnitine
  • Capecitabine
  • Cholic Acid
  • Clopidogrel
  • Cyclandelate
  • Indomethacin
  • Irinotecan
  • Oseltamivir
  • Probucol
  • Rufinamide
  • Selexipag
  • Tamoxifen
  • Trandolapril
  • Ciclesonide
  • Mycophenolate Mofetil
  • Benzocaine
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| ACAT| acyl coenzyme A:cholesterol acyltransferase| alternative pig liver esterase| APLE| brain carboxylesterase hBr1| carboxylesterase 1 (monocyte/macrophage serine esterase 1)| carboxylesterase 2 (liver)| carboxylesterase D1| CB1_000017001| CE-1| CEH| CES| CES2| CESDD1| CES-K1| cholesteryl ester hydrolase| cocaine carboxylesterase| egasyn| Fatty acyl-CoA hydrolase precursor, medium chain| hCE-1| hmse| hmse1| human monocyte/macrophage serine esterase 1| I79_010458| liver carboxylesterase| Liver carboxylesterase 1| liver carboxylesterase-like protein| methylumbelliferyl-acetate deacetylase 1| monocyte/macrophage serine esterase| N310_00142| N325_10737| N327_11466| N333_06967| N335_08744| N336_00231| pce-1| PMPMEase| prenylated methylated protein methyl esterase| proline-beta-naphthylamidase| REH| retinyl ester hydrolase| serine esterase 1| SES1| TGH| thiolesterase B| triacylglycerol hydrolase| ces1

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